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• W3169651014 abstract "To evaluate treatment utilization and patient burden in a multi-country, observational LOngitudinal Trial to Understand Symptomatology in Prurigo Nodularis (LOTUS-PN). Prospective, multicenter, longitudinal study conducted in 11 sites in the United States and Europe to investigate PN pathophysiology. Patient demographics, medical conditions, treatments, and 6-months´s follow-up data for PN Intensity/Itch Severity, Patient-Reported Outcomes Measurement Information System (PROMIS 8a), Dermatology Life Quality Index (DLQI), and Pruritus Patient Benefit Index (PBI-P) were analyzed for 54 patients, with a physician-confirmed PN diagnosis with underlying conditions, who completed assessments from March 2017-September 2018. Patients (mean age 54 years [53.8+12.9] at diagnosis) were predominantly female (57%), and white (65%). Underlying medical conditions included depression (20%), hypothyroidism (19%), atopic dermatitis (17%), asthma (15%), allergic rhinitis (11%), and HIV/AIDS (6%). Participants reported treatment regimens of topical corticosteroids (39%), phototherapy (28%), antihistamines (22%), gabapentin (15%), oral and intralesional corticosteroids (9% each) and cyclosporine (7%); 15% had no treatment. At baseline, patients reported a mean score of 6.1+1.2 (numerical rating scale from “0” to “10”) for itch severity over the past 24 hours, and this average rating dropped to 4.0+0.6 by 6 months. For sleep quality, 24% indicated “very poor” and “poor” at baseline with similar responses observed at 6 months. Baseline total DLQI scores declined from 12.0±7.2 (“very large effect”) to 7.8±5.8 (“moderate effect”) at 6 months. PBI-P items most important to respondents (>70% of participants responding “very important” both at baseline and 6-month follow-up), included: 1) itch free, 2) healed of all skin defects, 3) clear diagnosis, and therapy and 4) confidence in the therapy. This observational longitudinal cohort demonstrated the substantial burden, undertreatment and unmet needs in PN patients despite conventional therapy. Targeted, safe and effective treatments that resolve PN symptoms and improve quality of life are needed for this difficult-to-treat disease." @default.
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• W3169651014 date "2021-06-01" @default.
• W3169651014 modified "2023-10-15" @default.
• W3169651014 title "PRO69 Real-World Treatments and Health-Related Quality of Life in Patients with Prurigo Nodularis in the Lotus PN Observational Trial" @default.
• W3169651014 doi "https://doi.org/10.1016/j.jval.2021.04.1054" @default.
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