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- W3169691378 endingPage "972" @default.
- W3169691378 startingPage "945" @default.
- W3169691378 abstract "Iron is an essential mineral that serves as a prosthetic group for a variety of proteins involved in vital cellular processes. The iron economy within humans is highly conserved in that there is no proper iron excretion pathway. Therefore, iron homeostasis is highly evolved to coordinate iron acquisition, storage, transport, and recycling efficiently. A disturbance in this state can result in excess iron burden in which an ensuing iron-mediated generation of reactive oxygen species imparts widespread oxidative damage to proteins, lipids, and DNA. On the contrary, problems in iron deficiency either due to genetic or nutritional causes can lead to a number of iron deficiency disorders. Iron chelation strategies have been in the works since the early 1900s, and they still remain the most viable therapeutic approach to mitigate the toxic side effects of excess iron. Intense investigations on improving the efficacy of chelation strategies while being well tolerated and accepted by patients have been a particular focus for many researchers over the past 30 years. Moreover, recent advances in our understanding on the role of iron in the pathogenesis of different diseases (both in iron overload and iron deficiency conditions) motivate the need to develop new therapeutics. We summarized recent investigations into the role of iron in health and disease conditions, iron chelation, and iron delivery strategies. Information regarding small molecule as well as macromolecular approaches and how they are employed within different disease pathogenesis such as primary and secondary iron overload diseases, cancer, diabetes, neurodegenerative diseases, infections, and in iron deficiency is provided." @default.
- W3169691378 created "2021-06-22" @default.
- W3169691378 creator A5001822496 @default.
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- W3169691378 creator A5043051746 @default.
- W3169691378 creator A5082418430 @default.
- W3169691378 date "2021-06-09" @default.
- W3169691378 modified "2023-10-16" @default.
- W3169691378 title "Role of Iron in the Molecular Pathogenesis of Diseases and Therapeutic Opportunities" @default.
- W3169691378 cites W1004856969 @default.
- W3169691378 cites W109599821 @default.
- W3169691378 cites W1488741256 @default.
- W3169691378 cites W1497514444 @default.
- W3169691378 cites W1510337726 @default.
- W3169691378 cites W1510811131 @default.
- W3169691378 cites W1531783896 @default.
- W3169691378 cites W1533635653 @default.
- W3169691378 cites W1534008913 @default.
- W3169691378 cites W1568628619 @default.
- W3169691378 cites W157133164 @default.
- W3169691378 cites W1587543570 @default.
- W3169691378 cites W1595921363 @default.
- W3169691378 cites W1600773652 @default.
- W3169691378 cites W1601438958 @default.
- W3169691378 cites W1604820027 @default.
- W3169691378 cites W1618001767 @default.
- W3169691378 cites W1761222131 @default.
- W3169691378 cites W1805394574 @default.
- W3169691378 cites W1819656085 @default.
- W3169691378 cites W182194571 @default.
- W3169691378 cites W1834460521 @default.
- W3169691378 cites W1862590115 @default.
- W3169691378 cites W187102695 @default.
- W3169691378 cites W1917706383 @default.
- W3169691378 cites W1963703308 @default.
- W3169691378 cites W1964588743 @default.
- W3169691378 cites W1964990513 @default.
- W3169691378 cites W1966040155 @default.
- W3169691378 cites W1967760762 @default.
- W3169691378 cites W1967922486 @default.
- W3169691378 cites W1970096539 @default.
- W3169691378 cites W1970755611 @default.
- W3169691378 cites W1973077436 @default.
- W3169691378 cites W1973122898 @default.
- W3169691378 cites W1973514758 @default.
- W3169691378 cites W1974623765 @default.
- W3169691378 cites W1974844038 @default.
- W3169691378 cites W1975347582 @default.
- W3169691378 cites W1975497763 @default.
- W3169691378 cites W1975833123 @default.
- W3169691378 cites W1976215046 @default.
- W3169691378 cites W1976910163 @default.
- W3169691378 cites W1977173083 @default.
- W3169691378 cites W1978774658 @default.
- W3169691378 cites W1979628099 @default.
- W3169691378 cites W1980042430 @default.
- W3169691378 cites W1980679404 @default.
- W3169691378 cites W1981753435 @default.
- W3169691378 cites W1982608470 @default.
- W3169691378 cites W1985421547 @default.
- W3169691378 cites W1986757417 @default.
- W3169691378 cites W1987326742 @default.
- W3169691378 cites W1988150327 @default.
- W3169691378 cites W1988362755 @default.
- W3169691378 cites W1994378831 @default.
- W3169691378 cites W1995087031 @default.
- W3169691378 cites W1996152690 @default.
- W3169691378 cites W1997977268 @default.
- W3169691378 cites W1998754632 @default.
- W3169691378 cites W1998788539 @default.
- W3169691378 cites W2000490880 @default.
- W3169691378 cites W2001653119 @default.
- W3169691378 cites W2003006151 @default.
- W3169691378 cites W2003931467 @default.
- W3169691378 cites W2004332359 @default.
- W3169691378 cites W2004609934 @default.
- W3169691378 cites W2008883395 @default.
- W3169691378 cites W2009878128 @default.
- W3169691378 cites W2010802040 @default.
- W3169691378 cites W2011262372 @default.
- W3169691378 cites W2012486557 @default.
- W3169691378 cites W2012852339 @default.
- W3169691378 cites W2012956876 @default.
- W3169691378 cites W2014924942 @default.
- W3169691378 cites W2017076841 @default.
- W3169691378 cites W2017433201 @default.
- W3169691378 cites W2018411741 @default.
- W3169691378 cites W2018938097 @default.
- W3169691378 cites W2020932850 @default.
- W3169691378 cites W2021010261 @default.
- W3169691378 cites W2021473726 @default.
- W3169691378 cites W2022708198 @default.
- W3169691378 cites W2023483654 @default.
- W3169691378 cites W2024234732 @default.
- W3169691378 cites W2025063713 @default.
- W3169691378 cites W2026210357 @default.
- W3169691378 cites W2027426905 @default.