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- W3169696501 abstract "• Poor solubility of drugs is one of the adversities faced for its therapeutic use. • Micelles has been showing efficiency to assist in the carrying poorly soluble drugs. • Binary mixtures have a greater ability to increase drug solubility. • Micelles as Lapachol nanocarriers have potential application in cancer treatment. The use of copolymeric micelles of copoly(oxyalkylene)s for dissolution of poorly soluble bioactive compounds has been studied due to their efficiency in the blood dilution process and biocompatibility. In this study we investigated the use of micellar system of copolymers F127, EO 65 SO 9 EO 65 (EO = ethylene oxide/SO = styrene oxide) and the binary mixtures of these copolymers for the solubilization of lapachol. Solubility was estimated by UV–Vis. The samples, with and without drug, were characterized by X-ray, DSC, particle size and zeta potential. The antioxidant activity, the cytotoxicity and the release assay for the system SO 9 70(blend of EO 65 SO 9 EO 65 /F127 in the proportions 70/30) were also investigated. The SO 9 70LA system presented the best solubilization capacity (S cp ) value. It showed antioxidant activity, a prolonged release time, non-toxic with LC 50 > 1000 and a cytotoxic effect on cancer cells. Results showed IC 50 values starting at 5.8 μg mL −1 for the free lapachol and 12.3 μg mL −1 for the lapachol-loaded. Therefore, the system presents a potential for anticancer application." @default.
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- W3169696501 date "2021-09-01" @default.
- W3169696501 modified "2023-10-11" @default.
- W3169696501 title "Lapachol-loaded triblock copoly(oxyalkylene)s micelles: Potential use for anticancer treatment" @default.
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- W3169696501 doi "https://doi.org/10.1016/j.molliq.2021.116657" @default.
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