Matches in SemOpenAlex for { <https://semopenalex.org/work/W3169713843> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W3169713843 abstract "We hypothesized that modulation of myocardial voltage-dependent anion channel (VDAC)/mitoKATP channels can affect the survival, release of cytochrome C during sepsis. Male Sprague-Dawley rats (350–400g) were made septic using 200mg/kg cecal inoculum, ip. VDAC mRNA and protein expression was determined in the myocardium and isolated single adult rat ventricular myocytes (ARVMs) obtained from sham and septic rats. In addition, mitochondria and cytosolic fractions were isolated from ARVM treated with norepinephrine (NE, 10μmoles) ± 5-Hydroxydecanoic acid (5HD; 100μmoles). The 5HD treatment at the time of the induction of sepsis increased the survival and reversed the sepsis-induced hypotension and hypothermia at 6–24h. Sepsis-induced mitochondrial membrane potential (ΔΨm) collapse in ARVMs was reversed by 5HD treatment. Sepsis also downregulated the colocalization of ANT with VDAC1 in isolated purified mitochondrial preparation (PMPs) obtained from septic ARVMs. Sepsis produced a significant down-regulation of VDAC mRNA and protein along with upregulation of Bax in both myocardium and ARVMs. The 5HD treatment blocked NE-induced decrease in VDAC expression and the release of cytochrome C in septic ARVMs. It appears that modulation of mitoKATP channels and increases the release of cytochrome C may play a crucial role in sepsis-induced cardiomyocyte dysfunction." @default.
- W3169713843 created "2021-06-22" @default.
- W3169713843 creator A5022226582 @default.
- W3169713843 creator A5042138855 @default.
- W3169713843 creator A5086428720 @default.
- W3169713843 date "2010-04-01" @default.
- W3169713843 modified "2023-09-27" @default.
- W3169713843 title "Modulation of myocardial mitochondrial VDAC/MitoK ATP channels in sepsis" @default.
- W3169713843 doi "https://doi.org/10.1096/fasebj.24.1_supplement.961.15" @default.
- W3169713843 hasPublicationYear "2010" @default.
- W3169713843 type Work @default.
- W3169713843 sameAs 3169713843 @default.
- W3169713843 citedByCount "0" @default.
- W3169713843 crossrefType "journal-article" @default.
- W3169713843 hasAuthorship W3169713843A5022226582 @default.
- W3169713843 hasAuthorship W3169713843A5042138855 @default.
- W3169713843 hasAuthorship W3169713843A5086428720 @default.
- W3169713843 hasConcept C104317684 @default.
- W3169713843 hasConcept C126322002 @default.
- W3169713843 hasConcept C134018914 @default.
- W3169713843 hasConcept C146587185 @default.
- W3169713843 hasConcept C185592680 @default.
- W3169713843 hasConcept C200784783 @default.
- W3169713843 hasConcept C2778384902 @default.
- W3169713843 hasConcept C2779058106 @default.
- W3169713843 hasConcept C28859421 @default.
- W3169713843 hasConcept C29311851 @default.
- W3169713843 hasConcept C547475151 @default.
- W3169713843 hasConcept C55493867 @default.
- W3169713843 hasConcept C71924100 @default.
- W3169713843 hasConcept C86803240 @default.
- W3169713843 hasConcept C95444343 @default.
- W3169713843 hasConcept C98274493 @default.
- W3169713843 hasConceptScore W3169713843C104317684 @default.
- W3169713843 hasConceptScore W3169713843C126322002 @default.
- W3169713843 hasConceptScore W3169713843C134018914 @default.
- W3169713843 hasConceptScore W3169713843C146587185 @default.
- W3169713843 hasConceptScore W3169713843C185592680 @default.
- W3169713843 hasConceptScore W3169713843C200784783 @default.
- W3169713843 hasConceptScore W3169713843C2778384902 @default.
- W3169713843 hasConceptScore W3169713843C2779058106 @default.
- W3169713843 hasConceptScore W3169713843C28859421 @default.
- W3169713843 hasConceptScore W3169713843C29311851 @default.
- W3169713843 hasConceptScore W3169713843C547475151 @default.
- W3169713843 hasConceptScore W3169713843C55493867 @default.
- W3169713843 hasConceptScore W3169713843C71924100 @default.
- W3169713843 hasConceptScore W3169713843C86803240 @default.
- W3169713843 hasConceptScore W3169713843C95444343 @default.
- W3169713843 hasConceptScore W3169713843C98274493 @default.
- W3169713843 hasIssue "S1" @default.
- W3169713843 hasLocation W31697138431 @default.
- W3169713843 hasOpenAccess W3169713843 @default.
- W3169713843 hasPrimaryLocation W31697138431 @default.
- W3169713843 hasRelatedWork W2019843278 @default.
- W3169713843 hasRelatedWork W2038428660 @default.
- W3169713843 hasRelatedWork W2052843371 @default.
- W3169713843 hasRelatedWork W2058418154 @default.
- W3169713843 hasRelatedWork W2088337122 @default.
- W3169713843 hasRelatedWork W2160395831 @default.
- W3169713843 hasRelatedWork W2321452523 @default.
- W3169713843 hasRelatedWork W2367670834 @default.
- W3169713843 hasRelatedWork W4311046073 @default.
- W3169713843 hasRelatedWork W932784800 @default.
- W3169713843 hasVolume "24" @default.
- W3169713843 isParatext "false" @default.
- W3169713843 isRetracted "false" @default.
- W3169713843 magId "3169713843" @default.
- W3169713843 workType "article" @default.