Matches in SemOpenAlex for { <https://semopenalex.org/work/W3169739087> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W3169739087 abstract "Calcifying pseudoneoplasm of the neuraxis (CAPNON) is a rare tumefactive lesion with unclear pathogenesis. It is diagnosed by pathological findings of the typical histological features that include granular amorphous cores with palisading spindle to epithelioid cells, variable fibrous stroma, foreign-body reaction with giant cells, and calcification/ossification occasionally with psammoma bodies. However, its histopathology may be variable and currently immunohistochemistry plays a limited role in its diagnosis and understanding the pathogenesis. In this study, we examined 6 cases of CAPNONs including 3 intracranial and 3 spinal epidural lesions (age range: 59–69 years; 3 males and 3 females). Immunohistochemistry revealed that all CAPNON cores contain abundant positive deposits of neurofilament protein (NFP), which was supported by electron microscopy finding of filaments (8–13 nm in diameter). In comparison, no NFP positivity was found in 5 psammomatous/metaplastic meningiomas or 7 intervertebral tissue lesions with calcification/ossification. In addition, CAPNON cellular areas showed variable numbers of CD8+ cytotoxic T-cells with less CD4+ T-cells and a decreased ratio of CD4/CD8+ cells, versus the intervertebral tissue lesions without CD8+ or CD4+ cells. Our findings suggest that NFP may be a principal constituent of CAPNONs, and thus involved in the pathogenesis of CAPNON. Given the decreased CD4/CD8 ratio, the pathogenic process of CAPNON is possibly immune- mediated. LEARNING OBJECTIVES The presentation will enable the learner to: 1. Discuss histopathological features of calcifying pseudoneoplasm of the neuraxis (CAPNON) with variation of non-core components. 2. Explore diagnostic and pathogenic roles of immunohistochemical markers including neurofilament protein and CD4/CD8 in CAPNON." @default.
- W3169739087 created "2021-06-22" @default.
- W3169739087 creator A5005401436 @default.
- W3169739087 creator A5011430072 @default.
- W3169739087 creator A5014636429 @default.
- W3169739087 creator A5020776381 @default.
- W3169739087 creator A5023758271 @default.
- W3169739087 creator A5040188893 @default.
- W3169739087 creator A5071170650 @default.
- W3169739087 creator A5089356031 @default.
- W3169739087 date "2021-05-01" @default.
- W3169739087 modified "2023-09-27" @default.
- W3169739087 title "Diagnostic and pathogenic features of calcifying pseudoneoplasm of the neuraxis" @default.
- W3169739087 doi "https://doi.org/10.1017/cjn.2021.90" @default.
- W3169739087 hasPublicationYear "2021" @default.
- W3169739087 type Work @default.
- W3169739087 sameAs 3169739087 @default.
- W3169739087 citedByCount "0" @default.
- W3169739087 crossrefType "journal-article" @default.
- W3169739087 hasAuthorship W3169739087A5005401436 @default.
- W3169739087 hasAuthorship W3169739087A5011430072 @default.
- W3169739087 hasAuthorship W3169739087A5014636429 @default.
- W3169739087 hasAuthorship W3169739087A5020776381 @default.
- W3169739087 hasAuthorship W3169739087A5023758271 @default.
- W3169739087 hasAuthorship W3169739087A5040188893 @default.
- W3169739087 hasAuthorship W3169739087A5071170650 @default.
- W3169739087 hasAuthorship W3169739087A5089356031 @default.
- W3169739087 hasBestOaLocation W31697390871 @default.
- W3169739087 hasConcept C105702510 @default.
- W3169739087 hasConcept C142724271 @default.
- W3169739087 hasConcept C157207234 @default.
- W3169739087 hasConcept C174865614 @default.
- W3169739087 hasConcept C204232928 @default.
- W3169739087 hasConcept C2778842504 @default.
- W3169739087 hasConcept C2780309369 @default.
- W3169739087 hasConcept C2780942790 @default.
- W3169739087 hasConcept C71924100 @default.
- W3169739087 hasConcept C86803240 @default.
- W3169739087 hasConceptScore W3169739087C105702510 @default.
- W3169739087 hasConceptScore W3169739087C142724271 @default.
- W3169739087 hasConceptScore W3169739087C157207234 @default.
- W3169739087 hasConceptScore W3169739087C174865614 @default.
- W3169739087 hasConceptScore W3169739087C204232928 @default.
- W3169739087 hasConceptScore W3169739087C2778842504 @default.
- W3169739087 hasConceptScore W3169739087C2780309369 @default.
- W3169739087 hasConceptScore W3169739087C2780942790 @default.
- W3169739087 hasConceptScore W3169739087C71924100 @default.
- W3169739087 hasConceptScore W3169739087C86803240 @default.
- W3169739087 hasLocation W31697390871 @default.
- W3169739087 hasOpenAccess W3169739087 @default.
- W3169739087 hasPrimaryLocation W31697390871 @default.
- W3169739087 hasRelatedWork W13440147 @default.
- W3169739087 hasRelatedWork W15017596 @default.
- W3169739087 hasRelatedWork W1891941 @default.
- W3169739087 hasRelatedWork W2087224 @default.
- W3169739087 hasRelatedWork W460103 @default.
- W3169739087 hasRelatedWork W6434572 @default.
- W3169739087 hasRelatedWork W7389565 @default.
- W3169739087 hasRelatedWork W7400240 @default.
- W3169739087 hasRelatedWork W9531242 @default.
- W3169739087 hasRelatedWork W14788064 @default.
- W3169739087 isParatext "false" @default.
- W3169739087 isRetracted "false" @default.
- W3169739087 magId "3169739087" @default.
- W3169739087 workType "article" @default.