FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3169741025> ?p ?o ?g. }

• W3169741025 endingPage "113603" @default.
• W3169741025 startingPage "113603" @default.
• W3169741025 abstract "We reported three distinct series of novel benzothiopyranones, derived from an active metabolite (M-1) of anti-TB agent 6b. These small molecules were evaluated for their biological activities against a range of Mycobacterium tuberculosis (M. tuberculosis) strains. Preliminary druggability evaluation demonstrated that M-1 showed good aqueous solubility and hepatocyte stability. Benzothiopyranones with acyl, sulfonyl and phosphoryl groups exhibited potent in vitro inhibitory activity against M. tuberculosis H37Rv and low cytotoxicity. In particular, compound 3d, containing a benzoate fragment, displayed marked metabolic stability and potent in vitro activity against drug-resistant tuberculosis clinical strains. Further druggability evaluation based on the identified compounds 3d, 4e and 5b is ongoing for the discovery of promising anti-TB agents." @default.
• W3169741025 created "2021-06-22" @default.
• W3169741025 creator A5018120077 @default.
• W3169741025 creator A5025090774 @default.
• W3169741025 creator A5033732336 @default.
• W3169741025 creator A5049594854 @default.
• W3169741025 creator A5061952948 @default.
• W3169741025 creator A5065830236 @default.
• W3169741025 creator A5070664635 @default.
• W3169741025 creator A5071458554 @default.
• W3169741025 creator A5072104573 @default.
• W3169741025 creator A5074942308 @default.
• W3169741025 date "2021-10-01" @default.
• W3169741025 modified "2023-09-27" @default.
• W3169741025 title "Identification of novel benzothiopyranones with ester and amide motifs derived from active metabolite as promising leads against Mycobacterium tuberculosis" @default.
• W3169741025 cites W1521708238 @default.
• W3169741025 cites W1976256007 @default.
• W3169741025 cites W2011730642 @default.
• W3169741025 cites W2059274860 @default.
• W3169741025 cites W2075222652 @default.
• W3169741025 cites W2089068540 @default.
• W3169741025 cites W2126989272 @default.
• W3169741025 cites W2272837046 @default.
• W3169741025 cites W2571356517 @default.
• W3169741025 cites W2612443835 @default.
• W3169741025 cites W2760393221 @default.
• W3169741025 cites W2810243982 @default.
• W3169741025 cites W2889938805 @default.
• W3169741025 cites W2916462129 @default.
• W3169741025 cites W2920019534 @default.
• W3169741025 cites W2922103556 @default.
• W3169741025 cites W2947353787 @default.
• W3169741025 cites W2950806097 @default.
• W3169741025 cites W2964549850 @default.
• W3169741025 cites W2971327834 @default.
• W3169741025 cites W3004522408 @default.
• W3169741025 cites W3010155407 @default.
• W3169741025 cites W3041532377 @default.
• W3169741025 cites W3043683703 @default.
• W3169741025 cites W3087872238 @default.
• W3169741025 cites W3091206235 @default.
• W3169741025 cites W4211157605 @default.
• W3169741025 doi "https://doi.org/10.1016/j.ejmech.2021.113603" @default.
• W3169741025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34126456" @default.
• W3169741025 hasPublicationYear "2021" @default.
• W3169741025 type Work @default.
• W3169741025 sameAs 3169741025 @default.
• W3169741025 citedByCount "7" @default.
• W3169741025 countsByYear W31697410252022 @default.
• W3169741025 countsByYear W31697410252023 @default.
• W3169741025 crossrefType "journal-article" @default.
• W3169741025 hasAuthorship W3169741025A5018120077 @default.
• W3169741025 hasAuthorship W3169741025A5025090774 @default.
• W3169741025 hasAuthorship W3169741025A5033732336 @default.
• W3169741025 hasAuthorship W3169741025A5049594854 @default.
• W3169741025 hasAuthorship W3169741025A5061952948 @default.
• W3169741025 hasAuthorship W3169741025A5065830236 @default.
• W3169741025 hasAuthorship W3169741025A5070664635 @default.
• W3169741025 hasAuthorship W3169741025A5071458554 @default.
• W3169741025 hasAuthorship W3169741025A5072104573 @default.
• W3169741025 hasAuthorship W3169741025A5074942308 @default.
• W3169741025 hasConcept C104317684 @default.
• W3169741025 hasConcept C10679952 @default.
• W3169741025 hasConcept C109316439 @default.
• W3169741025 hasConcept C142724271 @default.
• W3169741025 hasConcept C185592680 @default.
• W3169741025 hasConcept C202751555 @default.
• W3169741025 hasConcept C2777477808 @default.
• W3169741025 hasConcept C2777975735 @default.
• W3169741025 hasConcept C2778439535 @default.
• W3169741025 hasConcept C2779685592 @default.
• W3169741025 hasConcept C2781069245 @default.
• W3169741025 hasConcept C55493867 @default.
• W3169741025 hasConcept C71240020 @default.
• W3169741025 hasConcept C71924100 @default.
• W3169741025 hasConceptScore W3169741025C104317684 @default.
• W3169741025 hasConceptScore W3169741025C10679952 @default.
• W3169741025 hasConceptScore W3169741025C109316439 @default.
• W3169741025 hasConceptScore W3169741025C142724271 @default.
• W3169741025 hasConceptScore W3169741025C185592680 @default.
• W3169741025 hasConceptScore W3169741025C202751555 @default.
• W3169741025 hasConceptScore W3169741025C2777477808 @default.
• W3169741025 hasConceptScore W3169741025C2777975735 @default.
• W3169741025 hasConceptScore W3169741025C2778439535 @default.
• W3169741025 hasConceptScore W3169741025C2779685592 @default.
• W3169741025 hasConceptScore W3169741025C2781069245 @default.
• W3169741025 hasConceptScore W3169741025C55493867 @default.
• W3169741025 hasConceptScore W3169741025C71240020 @default.
• W3169741025 hasConceptScore W3169741025C71924100 @default.
• W3169741025 hasFunder F4320321540 @default.
• W3169741025 hasFunder F4320321849 @default.
• W3169741025 hasFunder F4320323137 @default.
• W3169741025 hasFunder F4320335960 @default.
• W3169741025 hasLocation W31697410251 @default.
• W3169741025 hasOpenAccess W3169741025 @default.
• W3169741025 hasPrimaryLocation W31697410251 @default.
• W3169741025 hasRelatedWork W1501366337 @default.
• W3169741025 hasRelatedWork W1983900740 @default.

• next