FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3169780372> ?p ?o ?g. }

• W3169780372 endingPage "202" @default.
• W3169780372 startingPage "193" @default.
• W3169780372 abstract "SUMOylation is one of the post-translational modifications that involves the covalent attachment of the small ubiquitin-like modifier (SUMO) to the substrate. SUMOylation regulates multiple biological processes, including myoblast proliferation, differentiation, and apoptosis. 2-D08 is a synthetically available flavone, which acts as a potent cell-permeable SUMOylation inhibitor. Its mechanism of action involves preventing the transfer of SUMO from the E2 thioester to the substrate without influencing SUMO-activating enzyme E1 (SAE-1/2) or E2 Ubc9-SUMO thioester formation. However, both the effects and mechanisms of 2-D08 on C2C12 myoblast cells remain unclear. In the present study, we found that treatment with 2-D08 inhibits C2C12 cell proliferation and differentiation. We confirmed that 2-D08 significantly hampers the viability of C2C12 cells. Additionally, it inhibited myogenic differentiation, decreasing myosin heavy chain (MHC), MyoD, and myogenin expression. Furthermore, we confirmed that 2-D08-mediated anti-myogenic effects impair myoblast differentiation and myotube formation, reducing the number of MHC-positive C2C12 cells. In addition, we found that 2-D08 induces the activation of ErK1/2 and the degradation of MyoD and myogenin in C2C12 cells. Taken together, these results indicated that 2-D08 treatment results in the deregulated proliferation and differentiation of myoblasts. However, further research is needed to investigate the long-term effects of 2-D08 on skeletal muscles." @default.
• W3169780372 created "2021-06-22" @default.
• W3169780372 creator A5025424307 @default.
• W3169780372 creator A5075954620 @default.
• W3169780372 creator A5085913279 @default.
• W3169780372 date "2021-06-01" @default.
• W3169780372 modified "2023-10-17" @default.
• W3169780372 title "2-D08 treatment regulates C2C12 myoblast proliferation and differentiation via the Erk1/2 and proteasome signaling pathways" @default.
• W3169780372 cites W1521411817 @default.
• W3169780372 cites W1952358281 @default.
• W3169780372 cites W1965047073 @default.
• W3169780372 cites W1973963032 @default.
• W3169780372 cites W1974706622 @default.
• W3169780372 cites W1982864167 @default.
• W3169780372 cites W1988574423 @default.
• W3169780372 cites W1993476327 @default.
• W3169780372 cites W1999042605 @default.
• W3169780372 cites W2003965030 @default.
• W3169780372 cites W2005268809 @default.
• W3169780372 cites W2007070249 @default.
• W3169780372 cites W2017969831 @default.
• W3169780372 cites W2035726606 @default.
• W3169780372 cites W2035788269 @default.
• W3169780372 cites W2049129605 @default.
• W3169780372 cites W2056573861 @default.
• W3169780372 cites W2061777219 @default.
• W3169780372 cites W2062911743 @default.
• W3169780372 cites W2069463512 @default.
• W3169780372 cites W2071088250 @default.
• W3169780372 cites W2071374729 @default.
• W3169780372 cites W2078293551 @default.
• W3169780372 cites W2083405476 @default.
• W3169780372 cites W2083441653 @default.
• W3169780372 cites W2094344818 @default.
• W3169780372 cites W2095107146 @default.
• W3169780372 cites W2109014212 @default.
• W3169780372 cites W2110527130 @default.
• W3169780372 cites W2113731866 @default.
• W3169780372 cites W2116891450 @default.
• W3169780372 cites W2133585105 @default.
• W3169780372 cites W2136653559 @default.
• W3169780372 cites W2142058512 @default.
• W3169780372 cites W2154004479 @default.
• W3169780372 cites W2166440816 @default.
• W3169780372 cites W2167512318 @default.
• W3169780372 cites W2171071516 @default.
• W3169780372 cites W2194940061 @default.
• W3169780372 cites W2219305167 @default.
• W3169780372 cites W2258942936 @default.
• W3169780372 cites W2302790298 @default.
• W3169780372 cites W2467247368 @default.
• W3169780372 cites W2533098633 @default.
• W3169780372 cites W2597812329 @default.
• W3169780372 cites W2616902211 @default.
• W3169780372 cites W2695477722 @default.
• W3169780372 cites W2719903628 @default.
• W3169780372 cites W2783999843 @default.
• W3169780372 cites W2890800456 @default.
• W3169780372 cites W2896519010 @default.
• W3169780372 cites W2902129765 @default.
• W3169780372 cites W2936334991 @default.
• W3169780372 cites W2936421862 @default.
• W3169780372 cites W2946335029 @default.
• W3169780372 cites W3085918938 @default.
• W3169780372 doi "https://doi.org/10.1007/s10974-021-09605-x" @default.
• W3169780372 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8332585" @default.
• W3169780372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34142311" @default.
• W3169780372 hasPublicationYear "2021" @default.
• W3169780372 type Work @default.
• W3169780372 sameAs 3169780372 @default.
• W3169780372 citedByCount "2" @default.
• W3169780372 countsByYear W31697803722023 @default.
• W3169780372 crossrefType "journal-article" @default.
• W3169780372 hasAuthorship W3169780372A5025424307 @default.
• W3169780372 hasAuthorship W3169780372A5075954620 @default.
• W3169780372 hasAuthorship W3169780372A5085913279 @default.
• W3169780372 hasBestOaLocation W31697803721 @default.
• W3169780372 hasConcept C104317684 @default.
• W3169780372 hasConcept C148738053 @default.
• W3169780372 hasConcept C153911025 @default.
• W3169780372 hasConcept C171350616 @default.
• W3169780372 hasConcept C185592680 @default.
• W3169780372 hasConcept C207200792 @default.
• W3169780372 hasConcept C25602115 @default.
• W3169780372 hasConcept C2778106681 @default.
• W3169780372 hasConcept C3763915 @default.
• W3169780372 hasConcept C55493867 @default.
• W3169780372 hasConcept C60278653 @default.
• W3169780372 hasConcept C62112901 @default.
• W3169780372 hasConcept C6997183 @default.
• W3169780372 hasConcept C86803240 @default.
• W3169780372 hasConcept C95444343 @default.
• W3169780372 hasConcept C97816823 @default.
• W3169780372 hasConceptScore W3169780372C104317684 @default.
• W3169780372 hasConceptScore W3169780372C148738053 @default.
• W3169780372 hasConceptScore W3169780372C153911025 @default.
• W3169780372 hasConceptScore W3169780372C171350616 @default.
• W3169780372 hasConceptScore W3169780372C185592680 @default.

• next