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- W3169820007 abstract "Prostaglandin E2 (PGE2) is an important biological mediator involved in the defense against Mycobacterium tuberculosis (Mtb) infection. Currently, there are no reports on the mycobacterial components that regulate PGE2 production. Previously, we have reported that RpfE-treated dendritic cells (DCs) effectively expanded the Th1 and Th17 cell responses simultaneously; however, the mechanism underlying Th1 and Th17 cell differentiation is unclear. Here, we show that PGE2 produced by RpfE-activated DCs via the MAPK and cyclooxygenase 2 signaling pathways induces Th1 and Th17 cell responses mainly via the EP4 receptor. Furthermore, mice administered intranasally with PGE2 displayed RpfE-induced antigen-specific Th1 and Th17 responses with a significant reduction in bacterial load in the lungs. Furthermore, the addition of optimal PGE2 amount to IL-2-IL-6-IL-23p19-IL-1β was essential for promoting differentiation into Th1/Th17 cells with strong bactericidal activity. These results suggest that RpfE-matured DCs produce PGE2 that induces Th1 and Th17 cell differentiation with potent anti-mycobacterial activity." @default.
- W3169820007 created "2021-06-22" @default.
- W3169820007 creator A5035510089 @default.
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- W3169820007 creator A5081478831 @default.
- W3169820007 creator A5085302228 @default.
- W3169820007 creator A5088573270 @default.
- W3169820007 date "2021-07-14" @default.
- W3169820007 modified "2023-10-15" @default.
- W3169820007 title "Mycobacterium tuberculosis RpfE-Induced Prostaglandin E2 in Dendritic Cells Induces Th1/Th17 Cell Differentiation" @default.
- W3169820007 cites W1479876200 @default.
- W3169820007 cites W1655860314 @default.
- W3169820007 cites W1818355503 @default.
- W3169820007 cites W1874438006 @default.
- W3169820007 cites W1902222982 @default.
- W3169820007 cites W1940681873 @default.
- W3169820007 cites W1942374184 @default.
- W3169820007 cites W1967908436 @default.
- W3169820007 cites W1968678975 @default.
- W3169820007 cites W1969849186 @default.
- W3169820007 cites W1969903856 @default.
- W3169820007 cites W1973720948 @default.
- W3169820007 cites W1983754832 @default.
- W3169820007 cites W1985553702 @default.
- W3169820007 cites W1988906407 @default.
- W3169820007 cites W1996614926 @default.
- W3169820007 cites W1998000193 @default.
- W3169820007 cites W2005536703 @default.
- W3169820007 cites W2009716292 @default.
- W3169820007 cites W2011496417 @default.
- W3169820007 cites W2012680181 @default.
- W3169820007 cites W2012770902 @default.
- W3169820007 cites W2016754694 @default.
- W3169820007 cites W2017396583 @default.
- W3169820007 cites W2025377341 @default.
- W3169820007 cites W2029643641 @default.
- W3169820007 cites W2033878713 @default.
- W3169820007 cites W2034516005 @default.
- W3169820007 cites W2035031252 @default.
- W3169820007 cites W2038101863 @default.
- W3169820007 cites W2040622389 @default.
- W3169820007 cites W2043500875 @default.
- W3169820007 cites W2043827616 @default.
- W3169820007 cites W2045338903 @default.
- W3169820007 cites W2054081415 @default.
- W3169820007 cites W2056844634 @default.
- W3169820007 cites W2063294290 @default.
- W3169820007 cites W2065744920 @default.
- W3169820007 cites W2066973840 @default.
- W3169820007 cites W2069064769 @default.
- W3169820007 cites W2069968649 @default.
- W3169820007 cites W2072696221 @default.
- W3169820007 cites W2073827168 @default.
- W3169820007 cites W2076889715 @default.
- W3169820007 cites W2081521873 @default.
- W3169820007 cites W2084858972 @default.
- W3169820007 cites W2089034181 @default.
- W3169820007 cites W2090008075 @default.
- W3169820007 cites W2092734423 @default.
- W3169820007 cites W2105622887 @default.
- W3169820007 cites W2106471879 @default.
- W3169820007 cites W2112866067 @default.
- W3169820007 cites W2117340681 @default.
- W3169820007 cites W2122939321 @default.
- W3169820007 cites W2126227426 @default.
- W3169820007 cites W2126705913 @default.
- W3169820007 cites W2128149258 @default.
- W3169820007 cites W2129607075 @default.
- W3169820007 cites W2137199209 @default.
- W3169820007 cites W2142017607 @default.
- W3169820007 cites W2150396513 @default.
- W3169820007 cites W2151534353 @default.
- W3169820007 cites W2151566115 @default.
- W3169820007 cites W2154401560 @default.
- W3169820007 cites W2155779547 @default.
- W3169820007 cites W2156451877 @default.
- W3169820007 cites W2172279071 @default.
- W3169820007 cites W2265670240 @default.
- W3169820007 cites W2325936797 @default.
- W3169820007 cites W2588371443 @default.
- W3169820007 cites W2596346717 @default.
- W3169820007 cites W2769106867 @default.
- W3169820007 cites W2769926657 @default.
- W3169820007 cites W2776663677 @default.
- W3169820007 cites W2786287695 @default.
- W3169820007 cites W2910312028 @default.
- W3169820007 cites W3035078779 @default.
- W3169820007 cites W3103388110 @default.
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- W3169820007 doi "https://doi.org/10.3390/ijms22147535" @default.
- W3169820007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8304802" @default.
- W3169820007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34299161" @default.
- W3169820007 hasPublicationYear "2021" @default.
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