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• W3169849327 abstract "ABSTRACT Platinum (Pt) compounds such as oxaliplatin are amongst the most commonly prescribed anti-cancer drugs. Despite their considerable clinical impact, the molecular basis of platinum cytotoxicity and cancer specificity remain unclear. Here, we show that oxaliplatin, a backbone for the treatment of colorectal cancer, causes liquid-liquid demixing of nucleoli at clinically-relevant concentrations by interfering with the interaction networks that organize nucleoli. This biophysical defect leads to cell cycle arrest, impaired rRNA processing and shutdown of PolI-mediated transcription, ultimately resulting in cell death. We propose that the mechanism of action of oxaliplatin provides a blueprint for the therapeutic targeting of the increasing number of cellular processes being linked to biomolecular condensates." @default.
• W3169849327 created "2021-06-22" @default.
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• W3169849327 date "2021-06-11" @default.
• W3169849327 modified "2023-10-18" @default.
• W3169849327 title "Oxaliplatin kills cells via liquid-liquid demixing of nucleoli" @default.
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• W3169849327 doi "https://doi.org/10.1101/2021.06.10.447918" @default.
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