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• W3169967031 abstract "Acute myeloid leukemia (AML) is one of the most common hematopoietic malignancies that has an unfavorable outcome and a high rate of relapse. Autophagy plays a vital role in the development of and therapeutic responses to leukemia. This study identifies a potential autophagy-related signature to monitor the prognoses of patients of AML. Transcriptomic profiles of AML patients (GSE37642) with the relevant clinical information were downloaded from Gene Expression Omnibus (GEO) as the training set while TCGA-AML and GSE12417 were used as validation cohorts. Univariate regression analyses and multivariate stepwise Cox regression analysis were respectively applied to identify the autophagy-related signature. The univariate Cox regression analysis identified 32 autophagy-related genes (ARGs) that were significantly associated with the overall survival (OS) of the patients, and were mainly rich in signaling pathways for autophagy, p53, AMPK, and TNF. A prognostic signature that comprised eight ARGs (BAG3, CALCOCO2, CAMKK2, CANX, DAPK1, P4HB, TSC2, and ULK1) and had good predictive capacity was established by LASSO-Cox stepwise regression analysis. High-risk patients were found to have significantly shorter OS than patients in low-risk group. The signature can be used as an independent prognostic predictor after adjusting for clinicopathological parameters, and was validated on two external AML sets. Differentially expressed genes analyzed in two groups were involved in inflammatory and immune signaling pathways. An analysis of tumor-infiltrating immune cells confirmed that high-risk patients had a strong immunosuppressive microenvironment. Potential druggable OS-related ARGs were then investigated through protein-drug interactions. This study provides a systematic analysis of ARGs and develops an OS-related prognostic predictor for AML patients. Further work is needed to verify its clinical utility and identify the underlying molecular mechanisms in AML." @default.
• W3169967031 created "2021-06-22" @default.
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• W3169967031 date "2021-05-31" @default.
• W3169967031 modified "2023-09-26" @default.
• W3169967031 title "Prognosis and Characterization of Immune Microenvironment in Acute Myeloid Leukemia Through Identification of an Autophagy-Related Signature" @default.
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• W3169967031 cites W1975783419 @default.
• W3169967031 cites W1975915706 @default.
• W3169967031 cites W1983853906 @default.
• W3169967031 cites W1985987855 @default.
• W3169967031 cites W1990622149 @default.
• W3169967031 cites W1994823455 @default.
• W3169967031 cites W2003424912 @default.
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• W3169967031 cites W2560346983 @default.
• W3169967031 cites W2563527191 @default.
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• W3169967031 doi "https://doi.org/10.3389/fimmu.2021.695865" @default.
• W3169967031 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8200670" @default.
• W3169967031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34135913" @default.
• W3169967031 hasPublicationYear "2021" @default.
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