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• W3169968408 abstract "Interleukin-17E (IL-25) is a member of the IL-17 cytokine family that includes IL-17A to IL-17F. IL-17 family cytokines play a key role in host defense responses and inflammatory diseases. Compared with other IL-17 cytokine family members, IL-25 has relatively low sequence similarity to IL-17A and exhibits a distinct function from other IL-17 cytokines. IL-25 binds to its receptor composed of IL-17 receptor A (IL-17RA) and IL-17 receptor B (IL-17RB) for signal transduction. IL-25 has been implicated as a type 2 cytokine and can induce the production of IL-4, IL-5 and IL-13, which in turn inhibits the differentiation of T helper (Th) 17. In addition to its anti-inflammatory properties, IL-25 also exhibits a pro-inflammatory effect in the pathogenesis of Th17-dominated diseases. Here, we review recent advances in the roles of IL-25 in the pathogenesis of inflammation and autoimmune diseases." @default.
• W3169968408 created "2021-06-22" @default.
• W3169968408 creator A5015142199 @default.
• W3169968408 creator A5020328511 @default.
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• W3169968408 creator A5081870577 @default.
• W3169968408 creator A5089333480 @default.
• W3169968408 date "2021-05-28" @default.
• W3169968408 modified "2023-10-05" @default.
• W3169968408 title "Roles of IL-25 in Type 2 Inflammation and Autoimmune Pathogenesis" @default.
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