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- W3170150656 abstract "The transport of mRNA out of the nucleus is an essential step, which is necessary to accomplish gene expression. During their synthesis, mRNAs are packaged into mRNPs and exported through the nuclear pore complex (NPC). Several studies have established links between the factors involved in transcription and export of mRNA. Strong evidence that these processes are coupled was provided by the identification of yeast Sus1 as a subunit of both the SAGA complex and the TREX2 complex; the latter is associated with the NPC, and acts in mRNA export and transcription elongation. Notably, the function of both SAGA and TREX2 are conserved, as a homologous complex—known as SAGA and AMEX—have been characterized. Sus1 participates in different steps during gene expression. Our work is focus on unveiling the mechanisms that coordinate the different steps during gene expression are coupled. Here we will present new data concerning Sus1 role in SAGA and SLIK and a novel link between Sus1 and histones metabolism." @default.
- W3170150656 created "2021-06-22" @default.
- W3170150656 creator A5005842556 @default.
- W3170150656 date "2010-04-01" @default.
- W3170150656 modified "2023-10-17" @default.
- W3170150656 title "Sus1, A Key Factor Coupling Transcription and mRNA Export" @default.
- W3170150656 doi "https://doi.org/10.1096/fasebj.24.1_supplement.406.3" @default.
- W3170150656 hasPublicationYear "2010" @default.
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