Matches in SemOpenAlex for { <https://semopenalex.org/work/W317016891> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W317016891 abstract "Benzidine and 4-aminobiphenyl (4-ABP) are activated by intact plant cells and cell free TX1MX into mutagenic metabolites that induce frameshift and base pair substitution mutations in Salmonella typhimurium strains. The plant activation of these agents in plant peroxidase-mediated and bacterial O-acetyltransferase (OAT) dependent. This study was conducted to determine if the plant-activation of benzidine and 4-ABP follows the prostaglandin H synthase-mediated activation pathway in mammals. TX1MX-activated benzidine and 4-ABP were 1-50 {mu}M and 0.1-mM, respectively. The plant activation of benzidine and 4-ABP required a critical level of bacterial nitroreductase as well as OAT to metabolize the plant-activated products. In S. typhimurium strains that over express OAT, nitroreductase was required to metabolize these plant-activated aromatic amines into mutagens. Plant-activated benzidine and 4-ABP induced higher frameshift and base pair substitution mutations in OAT over expressing strains, YG1024 and YG1029 which have a single copy of the nitroreductase gene. The data indicate that the plant-activated benzidine and 4-ABP products have an absolute requirement for O-acetyltransferase in order to be mutagenic in S. typhimurium." @default.
- W317016891 created "2016-06-24" @default.
- W317016891 creator A5048566867 @default.
- W317016891 creator A5067727422 @default.
- W317016891 date "1997-10-01" @default.
- W317016891 modified "2023-09-24" @default.
- W317016891 title "Role of `classical nitroreductase` and O-acetyltransferase in the mutagenicity of plant activated aromatic amines" @default.
- W317016891 hasPublicationYear "1997" @default.
- W317016891 type Work @default.
- W317016891 sameAs 317016891 @default.
- W317016891 citedByCount "0" @default.
- W317016891 crossrefType "journal-article" @default.
- W317016891 hasAuthorship W317016891A5048566867 @default.
- W317016891 hasAuthorship W317016891A5067727422 @default.
- W317016891 hasConcept C104317684 @default.
- W317016891 hasConcept C114246631 @default.
- W317016891 hasConcept C117632636 @default.
- W317016891 hasConcept C119157956 @default.
- W317016891 hasConcept C181199279 @default.
- W317016891 hasConcept C185592680 @default.
- W317016891 hasConcept C2776639595 @default.
- W317016891 hasConcept C2779649592 @default.
- W317016891 hasConcept C2780267503 @default.
- W317016891 hasConcept C2781065037 @default.
- W317016891 hasConcept C2781326480 @default.
- W317016891 hasConcept C29906990 @default.
- W317016891 hasConcept C501734568 @default.
- W317016891 hasConcept C523546767 @default.
- W317016891 hasConcept C54355233 @default.
- W317016891 hasConcept C55493867 @default.
- W317016891 hasConcept C86803240 @default.
- W317016891 hasConceptScore W317016891C104317684 @default.
- W317016891 hasConceptScore W317016891C114246631 @default.
- W317016891 hasConceptScore W317016891C117632636 @default.
- W317016891 hasConceptScore W317016891C119157956 @default.
- W317016891 hasConceptScore W317016891C181199279 @default.
- W317016891 hasConceptScore W317016891C185592680 @default.
- W317016891 hasConceptScore W317016891C2776639595 @default.
- W317016891 hasConceptScore W317016891C2779649592 @default.
- W317016891 hasConceptScore W317016891C2780267503 @default.
- W317016891 hasConceptScore W317016891C2781065037 @default.
- W317016891 hasConceptScore W317016891C2781326480 @default.
- W317016891 hasConceptScore W317016891C29906990 @default.
- W317016891 hasConceptScore W317016891C501734568 @default.
- W317016891 hasConceptScore W317016891C523546767 @default.
- W317016891 hasConceptScore W317016891C54355233 @default.
- W317016891 hasConceptScore W317016891C55493867 @default.
- W317016891 hasConceptScore W317016891C86803240 @default.
- W317016891 hasLocation W3170168911 @default.
- W317016891 hasOpenAccess W317016891 @default.
- W317016891 hasPrimaryLocation W3170168911 @default.
- W317016891 hasRelatedWork W1501590175 @default.
- W317016891 hasRelatedWork W1989818344 @default.
- W317016891 hasRelatedWork W1998552445 @default.
- W317016891 hasRelatedWork W2000079980 @default.
- W317016891 hasRelatedWork W2018295294 @default.
- W317016891 hasRelatedWork W2036237343 @default.
- W317016891 hasRelatedWork W2040071667 @default.
- W317016891 hasRelatedWork W2043174818 @default.
- W317016891 hasRelatedWork W2050411970 @default.
- W317016891 hasRelatedWork W2056864901 @default.
- W317016891 hasRelatedWork W2070626154 @default.
- W317016891 hasRelatedWork W2075806496 @default.
- W317016891 hasRelatedWork W2081295860 @default.
- W317016891 hasRelatedWork W2081321419 @default.
- W317016891 hasRelatedWork W2086476198 @default.
- W317016891 hasRelatedWork W2090819061 @default.
- W317016891 hasRelatedWork W2111529122 @default.
- W317016891 hasRelatedWork W2143945931 @default.
- W317016891 hasRelatedWork W2167201566 @default.
- W317016891 hasRelatedWork W2917969394 @default.
- W317016891 hasVolume "29" @default.
- W317016891 isParatext "false" @default.
- W317016891 isRetracted "false" @default.
- W317016891 magId "317016891" @default.
- W317016891 workType "article" @default.