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- W3170196375 abstract ": Oesophageal perforation can be a devastating injury, associated with high morbidity and mortality. Known causes include iatrogenic, spontaneous, traumatic and foreign bodies. Iatrogenic perforations remain the most common. Early diagnosis is vital but difficult, as symptoms are often non-specific and sometimes relatively mild. Therefore, a high index of suspicion is important, especially after any oesophageal instrumentation or intra-thoracic surgery. The presentation of oesophageal perforation can vary significantly. Timing of diagnosis, presence of systemic symptoms, underlying oesophageal pathology, site and size of perforation influence management. In the lack of evidence, management options vary and there is not one recognized optimum treatment strategy, however there is consensus that oesophageal perforations managed within 24 hours have significantly better outcomes. Historically, the mainstay of treatment has been surgical, with methods including drainage and primary repair, exclusion and diversion techniques, and oesophagectomy. In carefully selected patients with a prompt diagnosis and no systemic symptoms a conservative approach has been successful. This includes fluid resuscitation, intravenous antimicrobials, nothing-by-mouth, gastric decompression and parenteral nutrition. Endoscopic clipping, suturing or stenting have gained popularity in the last couple of decades and are now established approaches in selected patients, as an alternative or in combination with surgery. Novel treatments include the use of endoscopic vacuum-assisted therapy (EVT). This review outlines the current approach to iatrogenic oesophageal perforation." @default.
- W3170196375 created "2021-06-22" @default.
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- W3170196375 date "2021-01-01" @default.
- W3170196375 modified "2023-10-16" @default.
- W3170196375 title "Iatrogenic oesophageal perforation" @default.
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- W3170196375 doi "https://doi.org/10.21037/shc-21-10" @default.
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