FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3170209840> ?p ?o ?g. }

• W3170209840 endingPage "723" @default.
• W3170209840 startingPage "711" @default.
• W3170209840 abstract "Modeling of retrospectively collected multi-center data of a rare disease in pediatrics is challenging because laboratory data can stem from several decades measured with different assays. Here we present a retrospective pharmacometrics (PMX) based data analysis of the rare disease congenital hypothyroidism (CH) in newborns and infants. Our overall aim is to develop a model that can be applied to optimize dosing in this pediatric patient population since suboptimal treatment of CH during the first 2 years of life is associated with a reduced intelligence quotient between 10 and 14 years. The first goal is to describe a retrospectively collected dataset consisting of 61 newborns and infants with CH up to 2 years of age. Overall, 505 measurements of free thyroxine (FT4) and 510 measurements of thyrotropin or thyroid-stimulating hormone were available from patients receiving substitution treatment with levothyroxine (LT4). The second goal is to introduce a scale/location-scale normalization method to merge available FT4 measurements since 34 different postnatal age- and assay-specific laboratory reference ranges were applied. This method takes into account the change of the distribution of FT4 values over time, i.e. a transformation from right-skewed towards normality during LT4 treatment. The third goal is to develop a practical and useful PMX model for LT4 treatment to characterize FT4 measurements, which is applicable within a clinical setting. In summary, a time-dependent normalization method and a practical PMX model are presented. Since there is no on-going or planned development of new pharmacological approaches for CH, PMX based modeling and simulation can be leveraged to personalize dosing with the goal to enhance longer-term neurological outcome in children with the rare disease CH." @default.
• W3170209840 created "2021-06-22" @default.
• W3170209840 creator A5004280057 @default.
• W3170209840 creator A5010483604 @default.
• W3170209840 creator A5024062850 @default.
• W3170209840 creator A5024383108 @default.
• W3170209840 creator A5032173880 @default.
• W3170209840 creator A5032729107 @default.
• W3170209840 creator A5033117925 @default.
• W3170209840 creator A5033220040 @default.
• W3170209840 creator A5033652865 @default.
• W3170209840 creator A5036377952 @default.
• W3170209840 creator A5046865872 @default.
• W3170209840 creator A5049305561 @default.
• W3170209840 creator A5051636167 @default.
• W3170209840 date "2021-06-11" @default.
• W3170209840 modified "2023-09-27" @default.
• W3170209840 title "Modeling of levothyroxine in newborns and infants with congenital hypothyroidism: challenges and opportunities of a rare disease multi-center study" @default.
• W3170209840 cites W1479716699 @default.
• W3170209840 cites W1970260134 @default.
• W3170209840 cites W1991787302 @default.
• W3170209840 cites W2000418951 @default.
• W3170209840 cites W2023162876 @default.
• W3170209840 cites W2032615301 @default.
• W3170209840 cites W2033995148 @default.
• W3170209840 cites W2044159627 @default.
• W3170209840 cites W2047159776 @default.
• W3170209840 cites W2052438117 @default.
• W3170209840 cites W2059270910 @default.
• W3170209840 cites W2060593036 @default.
• W3170209840 cites W2065639952 @default.
• W3170209840 cites W2072154655 @default.
• W3170209840 cites W2075021290 @default.
• W3170209840 cites W2075932932 @default.
• W3170209840 cites W2078119891 @default.
• W3170209840 cites W2101607054 @default.
• W3170209840 cites W2103918459 @default.
• W3170209840 cites W2104019719 @default.
• W3170209840 cites W2108376141 @default.
• W3170209840 cites W2120136039 @default.
• W3170209840 cites W2122765301 @default.
• W3170209840 cites W2128596992 @default.
• W3170209840 cites W2130404410 @default.
• W3170209840 cites W2135838846 @default.
• W3170209840 cites W2145695460 @default.
• W3170209840 cites W2505565526 @default.
• W3170209840 cites W2782067163 @default.
• W3170209840 cites W2782759999 @default.
• W3170209840 cites W2790723135 @default.
• W3170209840 cites W3108540964 @default.
• W3170209840 doi "https://doi.org/10.1007/s10928-021-09765-w" @default.
• W3170209840 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8405503" @default.
• W3170209840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34117565" @default.
• W3170209840 hasPublicationYear "2021" @default.
• W3170209840 type Work @default.
• W3170209840 sameAs 3170209840 @default.
• W3170209840 citedByCount "3" @default.
• W3170209840 countsByYear W31702098402022 @default.
• W3170209840 countsByYear W31702098402023 @default.
• W3170209840 crossrefType "journal-article" @default.
• W3170209840 hasAuthorship W3170209840A5004280057 @default.
• W3170209840 hasAuthorship W3170209840A5010483604 @default.
• W3170209840 hasAuthorship W3170209840A5024062850 @default.
• W3170209840 hasAuthorship W3170209840A5024383108 @default.
• W3170209840 hasAuthorship W3170209840A5032173880 @default.
• W3170209840 hasAuthorship W3170209840A5032729107 @default.
• W3170209840 hasAuthorship W3170209840A5033117925 @default.
• W3170209840 hasAuthorship W3170209840A5033220040 @default.
• W3170209840 hasAuthorship W3170209840A5033652865 @default.
• W3170209840 hasAuthorship W3170209840A5036377952 @default.
• W3170209840 hasAuthorship W3170209840A5046865872 @default.
• W3170209840 hasAuthorship W3170209840A5049305561 @default.
• W3170209840 hasAuthorship W3170209840A5051636167 @default.
• W3170209840 hasBestOaLocation W31702098401 @default.
• W3170209840 hasConcept C118552586 @default.
• W3170209840 hasConcept C126322002 @default.
• W3170209840 hasConcept C167135981 @default.
• W3170209840 hasConcept C187212893 @default.
• W3170209840 hasConcept C2775883008 @default.
• W3170209840 hasConcept C2776157432 @default.
• W3170209840 hasConcept C2779258352 @default.
• W3170209840 hasConcept C2908647359 @default.
• W3170209840 hasConcept C526584372 @default.
• W3170209840 hasConcept C71924100 @default.
• W3170209840 hasConcept C99454951 @default.
• W3170209840 hasConceptScore W3170209840C118552586 @default.
• W3170209840 hasConceptScore W3170209840C126322002 @default.
• W3170209840 hasConceptScore W3170209840C167135981 @default.
• W3170209840 hasConceptScore W3170209840C187212893 @default.
• W3170209840 hasConceptScore W3170209840C2775883008 @default.
• W3170209840 hasConceptScore W3170209840C2776157432 @default.
• W3170209840 hasConceptScore W3170209840C2779258352 @default.
• W3170209840 hasConceptScore W3170209840C2908647359 @default.
• W3170209840 hasConceptScore W3170209840C526584372 @default.
• W3170209840 hasConceptScore W3170209840C71924100 @default.
• W3170209840 hasConceptScore W3170209840C99454951 @default.
• W3170209840 hasFunder F4320310466 @default.
• W3170209840 hasFunder F4320320879 @default.

• next