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• W3170249570 abstract "Corticosteroid administration prior to the application of chemotherapy in small animal lymphoma patients is a concern, as it is discussed to negatively influence the therapeutic outcome due to corticosteroid-induced drug resistance. Using feline lymphoma cell lines FT-1 and MS4 we have shown, that prednisolone pre-treatment alters the susceptibility of these cells towards doxorubicin or vincristine treatment in vitro. The observed effect was negative as for the killing potential and it was cell line and drug (doxorubicin or vincristine) dependent. Furthermore, increase in mRNA expression of selected proteins with multidrug resistance potential (MDR1, BCRP, LRP, MT) was observed after prednisolone pre-treatment. Administration of chemical inhibitors of these proteins did not lead to reversal in sensitivity of tested cell lines to doxorubicin or vincristine." @default.
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• W3170249570 date "2021-09-01" @default.
• W3170249570 modified "2023-10-02" @default.
• W3170249570 title "Effect of prednisolone pre-treatment on cat lymphoma cell sensitivity towards chemotherapeutic drugs" @default.
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• W3170249570 doi "https://doi.org/10.1016/j.rvsc.2021.06.014" @default.
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