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- W3170333604 abstract "Lipid control is one of the most important secondary cardiovascular prevention targets. The 4S trial1 in 1994 was the first study to demonstrate the benefit of statin therapy in coronary artery disease patients. Ten years later, the PROVE IT-TIMI 222 showed the benefit of intensive vs. moderate statin therapy in patients with a recent acute coronary syndrome (ACS). Also, a meta-analysis published in 2010, from Cholesterol Treatment Trialists’ Collaboration3 demonstrated the benefit of even lower LDL and in 2015, the IMPROVE-IT trial4 showed the benefit of ezetimibe addition to statin in reduction of LDL levels and in cardiovascular outcomes. More recently, the FOURIER trial5 (2017) and the ODYSSEY Outcomes6 (2018) demonstrated the cardiovascular benefit of adding a PCSK9 inhibitor to optimized antidyslipidaemic therapy. Moreover, we now know that coronary interventions in chronic coronary syndromes seems not to improve patient outcomes; thus the need to..." @default.
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- W3170333604 date "2021-06-07" @default.
- W3170333604 modified "2023-10-16" @default.
- W3170333604 title "Secondary prevention after acute coronary syndrome: are dyslipidaemia guideline targets achieved?" @default.
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- W3170333604 doi "https://doi.org/10.1093/eurjpc/zwab070" @default.
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