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• W3170354885 abstract "Background: Despite the better prognosis given by surgical resection and chemotherapy in low-grade glioma (LGG), progressive transformation is still a huge concern. In this case, the S100A gene family, being capable of regulating inflammatory responses, can promote tumor development. Methods: The analysis was carried out via ONCOMINE, GEPIA, cBioPortal, String, GeneMANIA, WebGestalt, LinkedOmics, TIMER, CGGA, R 4.0.2 and immunohistochemistry. Results: S100A2, S100A6, S100A10, S100A11, and S100A16 were up-regulated and S100A1 and S100A13 were down-regulated in LGG compared to normal tissues. S100A3, S100A4, S100A8, and S100A9 expression was up-regulated during the progression of glioma grade. In addition, genetic variation of the S100A family was high in LGG, and the S100A family genes mostly function through IL-17 signaling pathway, S100 binding protein, and inflammatory responses. The TIMER database also revealed a relationship between gene expression and immune cell infiltration. High expression of S100A2, S100A3, S100A4, S100A6, S100A8, S100A9, S100A10, S100A11, S100A13, and S100A16 was significantly associated with poor prognosis in LGG patients. S100A family genes S100A2, S100A3, S100A6, S100A10, and S100A11 may be prognosis-related genes in LGG, and were significantly associated with IDH mutation and 1p19q codeletion. The immunohistochemical staining results also confirmed that S100A2, S100A3, S100A6, S100A10, and S100A11 expression was upregulated in LGG. Conclusion: The S100A family plays a vital role in LGG pathogenesis, presumably facilitating LGG progression via modulating inflammatory state and immune cell infiltration." @default.
• W3170354885 created "2021-06-22" @default.
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• W3170354885 date "2021-06-08" @default.
• W3170354885 modified "2023-10-16" @default.
• W3170354885 title "S100A gene family: immune-related prognostic biomarkers and therapeutic targets for low-grade glioma" @default.
• W3170354885 cites W1486421501 @default.
• W3170354885 cites W1823573254 @default.
• W3170354885 cites W1924455820 @default.
• W3170354885 cites W1964042670 @default.
• W3170354885 cites W1964605101 @default.
• W3170354885 cites W1974713508 @default.
• W3170354885 cites W1990930567 @default.
• W3170354885 cites W1995829023 @default.
• W3170354885 cites W2001099078 @default.
• W3170354885 cites W2001766670 @default.
• W3170354885 cites W2018760769 @default.
• W3170354885 cites W2020088986 @default.
• W3170354885 cites W2031648179 @default.
• W3170354885 cites W2035924088 @default.
• W3170354885 cites W2057142271 @default.
• W3170354885 cites W2062746659 @default.
• W3170354885 cites W2066749848 @default.
• W3170354885 cites W2071259232 @default.
• W3170354885 cites W2079210525 @default.
• W3170354885 cites W2083661051 @default.
• W3170354885 cites W2087762953 @default.
• W3170354885 cites W2107880288 @default.
• W3170354885 cites W2115597075 @default.
• W3170354885 cites W2125838034 @default.
• W3170354885 cites W2128205456 @default.
• W3170354885 cites W2131313137 @default.
• W3170354885 cites W2134244261 @default.
• W3170354885 cites W2149387197 @default.
• W3170354885 cites W2160382843 @default.
• W3170354885 cites W2164871149 @default.
• W3170354885 cites W2167135536 @default.
• W3170354885 cites W2167560492 @default.
• W3170354885 cites W2301044272 @default.
• W3170354885 cites W2306651097 @default.
• W3170354885 cites W2515338440 @default.
• W3170354885 cites W2582686270 @default.
• W3170354885 cites W2605286185 @default.
• W3170354885 cites W2606168811 @default.
• W3170354885 cites W2617586373 @default.
• W3170354885 cites W2746246740 @default.
• W3170354885 cites W2767198352 @default.
• W3170354885 cites W2769160599 @default.
• W3170354885 cites W2776794080 @default.
• W3170354885 cites W2788621111 @default.
• W3170354885 cites W2791657935 @default.
• W3170354885 cites W2808305854 @default.
• W3170354885 cites W2897072461 @default.
• W3170354885 cites W2898659456 @default.
• W3170354885 cites W2899223437 @default.
• W3170354885 cites W2902634143 @default.
• W3170354885 cites W2903400169 @default.
• W3170354885 cites W2904050669 @default.
• W3170354885 cites W2904248981 @default.
• W3170354885 cites W2904776046 @default.
• W3170354885 cites W2911871569 @default.
• W3170354885 cites W2912555011 @default.
• W3170354885 cites W2918488955 @default.
• W3170354885 cites W2921622709 @default.
• W3170354885 cites W2939093001 @default.
• W3170354885 cites W2946570295 @default.
• W3170354885 cites W2969665415 @default.
• W3170354885 cites W2972081901 @default.
• W3170354885 cites W2974291499 @default.
• W3170354885 cites W2984698492 @default.
• W3170354885 cites W2985184611 @default.
• W3170354885 cites W2992897657 @default.
• W3170354885 cites W2994525341 @default.
• W3170354885 cites W3003163062 @default.
• W3170354885 cites W3006133653 @default.
• W3170354885 cites W3011177832 @default.
• W3170354885 cites W3026331035 @default.
• W3170354885 cites W3035189605 @default.
• W3170354885 cites W3061413042 @default.
• W3170354885 cites W4249820877 @default.
• W3170354885 doi "https://doi.org/10.18632/aging.203103" @default.
• W3170354885 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8221329" @default.
• W3170354885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34148033" @default.
• W3170354885 hasPublicationYear "2021" @default.
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