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• W3170356275 abstract "Abstract GATA3 is as a lineage-specific transcription factor that drives the differentiation of CD4 + T helper 2 (Th2) cells, but is also involved in a variety of processes such as immune regulation, proliferation and maintenance in other T cell and non-T cell lineages. Here we show a mechanism utilised by CD4 + T cells to increase mitochondrial mass in response to DNA damage through the actions of GATA3 and AMPK. Activated AMPK increases expression of PPARG coactivator 1 alpha ( PPARGC1A or PGC1α protein) at the level of transcription and GATA3 at the level of translation, while DNA damage enhances expression of nuclear factor erythroid 2-related factor 2 ( NFE2L2 or NRF2). PGC1α, GATA3 and NRF2 complex together with the ATR to promote mitochondrial biogenesis. These findings extend the pleotropic interactions of GATA3 and highlight the potential for GATA3-targeted cell manipulation for intervention in CD4 + T cell viability and function after DNA damage." @default.
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• W3170356275 date "2021-06-07" @default.
• W3170356275 modified "2023-10-18" @default.
• W3170356275 title "GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage" @default.
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• W3170356275 doi "https://doi.org/10.1038/s41467-021-23715-7" @default.
• W3170356275 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8184923" @default.
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