FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3170384715> ?p ?o ?g. }

• W3170384715 abstract "Abstract Pelvic floor disorders, which include pelvic organ prolapse, and urinary and fecal incontinence, affect millions of women globally and represent a major public health concern. Pelvic floor muscle (PFM) dysfunction has been identified as one of the leading risk factors for the development of these morbid conditions. Even though childbirth, specifically vaginal delivery, has been long recognized as the most important potentially modifiable risk factor for PFM injury, the precise mechanisms of PFM dysfunction following childbirth remain elusive. In this study we demonstrate that PFMs undergo atrophy and severe fibrosis in parous women with symptomatic pelvic organ prolapse compared to age-matched nulliparous cadaveric donors without history of pelvic floor disorders. These pathological alterations are recapitulated in the pre-clinical rat model of simulated birth injury. The transcriptional signature of PFMs post-injury demonstrates a sustained inflammatory response, impairment in muscle anabolism, and persistent expression of extracellular matrix (ECM) remodeling genes. Next, we evaluated the administration of acellular injectable skeletal muscle extracellular matrix hydrogel for the prevention and mitigation of these pathological alterations. Treatment of PFMs with the biomaterial either at the time of birth injury or 4 weeks post-injury reduced muscle atrophy and mitigated fibrotic degeneration. By evaluating gene expression, we demonstrate that these changes are mainly driven by the hydrogel-induced modulation of the immune response and intramuscular fibrosis, as well as enhancement of the endogenous myogenesis. This work furthers our understanding of PFM birth injury and demonstrates proof-of-concept for a new pragmatic pro-regenerative biomaterial approach for treating injured PFMs." @default.
• W3170384715 created "2021-06-22" @default.
• W3170384715 creator A5001754292 @default.
• W3170384715 creator A5009860029 @default.
• W3170384715 creator A5015523340 @default.
• W3170384715 creator A5026483616 @default.
• W3170384715 creator A5029119814 @default.
• W3170384715 creator A5030334925 @default.
• W3170384715 creator A5040570147 @default.
• W3170384715 creator A5044110622 @default.
• W3170384715 creator A5044994001 @default.
• W3170384715 creator A5064028373 @default.
• W3170384715 creator A5066405493 @default.
• W3170384715 creator A5069032162 @default.
• W3170384715 creator A5069547131 @default.
• W3170384715 creator A5088046354 @default.
• W3170384715 creator A5089380647 @default.
• W3170384715 date "2021-05-28" @default.
• W3170384715 modified "2023-09-27" @default.
• W3170384715 title "Pro-regenerative Extracellular Matrix Hydrogel Prevents and Mitigates Pathological Alterations of Pelvic Muscles Following Birth Injury" @default.
• W3170384715 cites W1583146842 @default.
• W3170384715 cites W1852246525 @default.
• W3170384715 cites W1964690048 @default.
• W3170384715 cites W1986543208 @default.
• W3170384715 cites W1994077842 @default.
• W3170384715 cites W2024999779 @default.
• W3170384715 cites W2026748417 @default.
• W3170384715 cites W2031174779 @default.
• W3170384715 cites W2038412833 @default.
• W3170384715 cites W2042208403 @default.
• W3170384715 cites W2054692433 @default.
• W3170384715 cites W2057072817 @default.
• W3170384715 cites W2066056709 @default.
• W3170384715 cites W2075703747 @default.
• W3170384715 cites W2078696662 @default.
• W3170384715 cites W2082975886 @default.
• W3170384715 cites W2104089646 @default.
• W3170384715 cites W2112214413 @default.
• W3170384715 cites W2126582172 @default.
• W3170384715 cites W2134244003 @default.
• W3170384715 cites W2151136501 @default.
• W3170384715 cites W2153062118 @default.
• W3170384715 cites W2161212700 @default.
• W3170384715 cites W2207881491 @default.
• W3170384715 cites W2263715552 @default.
• W3170384715 cites W2267893954 @default.
• W3170384715 cites W2269067703 @default.
• W3170384715 cites W2291270203 @default.
• W3170384715 cites W2292568679 @default.
• W3170384715 cites W2313298058 @default.
• W3170384715 cites W2344685821 @default.
• W3170384715 cites W2585829088 @default.
• W3170384715 cites W2587398364 @default.
• W3170384715 cites W2593485651 @default.
• W3170384715 cites W2607766702 @default.
• W3170384715 cites W2756439877 @default.
• W3170384715 cites W2804731235 @default.
• W3170384715 cites W2885945321 @default.
• W3170384715 cites W2895816481 @default.
• W3170384715 cites W2965455118 @default.
• W3170384715 cites W2972319909 @default.
• W3170384715 cites W2974670438 @default.
• W3170384715 cites W2980692426 @default.
• W3170384715 cites W3022659605 @default.
• W3170384715 cites W3024868155 @default.
• W3170384715 cites W3088069114 @default.
• W3170384715 cites W3109941968 @default.
• W3170384715 cites W4255190007 @default.
• W3170384715 doi "https://doi.org/10.1101/2021.05.28.446170" @default.
• W3170384715 hasPublicationYear "2021" @default.
• W3170384715 type Work @default.
• W3170384715 sameAs 3170384715 @default.
• W3170384715 citedByCount "6" @default.
• W3170384715 countsByYear W31703847152021 @default.
• W3170384715 countsByYear W31703847152022 @default.
• W3170384715 crossrefType "posted-content" @default.
• W3170384715 hasAuthorship W3170384715A5001754292 @default.
• W3170384715 hasAuthorship W3170384715A5009860029 @default.
• W3170384715 hasAuthorship W3170384715A5015523340 @default.
• W3170384715 hasAuthorship W3170384715A5026483616 @default.
• W3170384715 hasAuthorship W3170384715A5029119814 @default.
• W3170384715 hasAuthorship W3170384715A5030334925 @default.
• W3170384715 hasAuthorship W3170384715A5040570147 @default.
• W3170384715 hasAuthorship W3170384715A5044110622 @default.
• W3170384715 hasAuthorship W3170384715A5044994001 @default.
• W3170384715 hasAuthorship W3170384715A5064028373 @default.
• W3170384715 hasAuthorship W3170384715A5066405493 @default.
• W3170384715 hasAuthorship W3170384715A5069032162 @default.
• W3170384715 hasAuthorship W3170384715A5069547131 @default.
• W3170384715 hasAuthorship W3170384715A5088046354 @default.
• W3170384715 hasAuthorship W3170384715A5089380647 @default.
• W3170384715 hasBestOaLocation W31703847151 @default.
• W3170384715 hasConcept C141071460 @default.
• W3170384715 hasConcept C142724271 @default.
• W3170384715 hasConcept C189165786 @default.
• W3170384715 hasConcept C207886595 @default.
• W3170384715 hasConcept C2776263037 @default.
• W3170384715 hasConcept C2779662851 @default.
• W3170384715 hasConcept C2780559512 @default.
• W3170384715 hasConcept C2781172350 @default.

• next