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- W3170394628 abstract "Atremorine is a novel bioproduct obtained by nondenaturing biotechnological processes from a genetic species of Vicia faba. Atremorine is a potent dopamine (DA) enhancer with powerful effects on the neuronal dopaminergic system, acting as a neuroprotective agent in Parkinson's disease (PD). Over 97% of PD patients respond to a single dose of Atremorine (5 g, p.o.) 1 h after administration. This response is gender-, time-, dose-, and genotype-dependent, with optimal doses ranging from 5 to 20 g/day, depending upon disease severity and concomitant medication. Drug-free patients show an increase in DA levels from 12.14 ± 0.34 pg/ml to 6463.21 ± 1306.90 pg/ml; and patients chronically treated with anti-PD drugs show an increase in DA levels from 1321.53 ± 389.94 pg/ml to 16,028.54 ± 4783.98 pg/ml, indicating that Atremorine potentiates the dopaminergic effects of conventional anti-PD drugs. Atremorine also influences the levels of other neurotransmitters (adrenaline, noradrenaline) and hormones which are regulated by DA (e.g., prolactin, PRL), with no effect on serotonin or histamine. The variability in Atremorine-induced DA response is highly attributable to pharmacogenetic factors. Polymorphic variants in pathogenic (SNCA, NUCKS1, ITGA8, GPNMB, GCH1, BCKDK, APOE, LRRK2, ACMSD), mechanistic (DRD2), metabolic (CYP2D6, CYP2C9, CYP2C19, CYP3A4/5, NAT2), transporter (ABCB1, SLC6A2, SLC6A3, SLC6A4) and pleiotropic genes (APOE) influence the DA response to Atremorine and its psychomotor and brain effects. Atremorine enhances DNA methylation and displays epigenetic activity via modulation of the pharmacoepigenetic network. Atremorine is a novel neuroprotective agent for dopaminergic neurons with potential prophylactic and therapeutic activity in PD." @default.
- W3170394628 created "2021-06-22" @default.
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- W3170394628 date "2021-06-09" @default.
- W3170394628 modified "2023-09-25" @default.
- W3170394628 title "Atremorine in Parkinson's disease: From dopaminergic neuroprotection to pharmacogenomics" @default.
- W3170394628 cites W1479935944 @default.
- W3170394628 cites W1546116904 @default.
- W3170394628 cites W1588992136 @default.
- W3170394628 cites W1633348432 @default.
- W3170394628 cites W1815242288 @default.
- W3170394628 cites W1823175426 @default.
- W3170394628 cites W1851334881 @default.
- W3170394628 cites W1905490847 @default.
- W3170394628 cites W1945569425 @default.
- W3170394628 cites W1950005663 @default.
- W3170394628 cites W1964544555 @default.
- W3170394628 cites W1975144545 @default.
- W3170394628 cites W1979527613 @default.
- W3170394628 cites W1979659124 @default.
- W3170394628 cites W1979763214 @default.
- W3170394628 cites W1982363275 @default.
- W3170394628 cites W1983353338 @default.
- W3170394628 cites W1983886526 @default.
- W3170394628 cites W1989108550 @default.
- W3170394628 cites W1989930057 @default.
- W3170394628 cites W1998572581 @default.
- W3170394628 cites W2003883601 @default.
- W3170394628 cites W2007086168 @default.
- W3170394628 cites W2008886854 @default.
- W3170394628 cites W2008964562 @default.
- W3170394628 cites W2009299369 @default.
- W3170394628 cites W2011961184 @default.
- W3170394628 cites W2016701287 @default.
- W3170394628 cites W2018580557 @default.
- W3170394628 cites W2018907079 @default.
- W3170394628 cites W2019922908 @default.
- W3170394628 cites W2021097923 @default.
- W3170394628 cites W2028498644 @default.
- W3170394628 cites W2030459377 @default.
- W3170394628 cites W2042062646 @default.
- W3170394628 cites W2045722213 @default.
- W3170394628 cites W2045993126 @default.
- W3170394628 cites W2046398127 @default.
- W3170394628 cites W2046969478 @default.
- W3170394628 cites W2050529946 @default.
- W3170394628 cites W2051086599 @default.
- W3170394628 cites W2060365969 @default.
- W3170394628 cites W2061995199 @default.
- W3170394628 cites W2063127941 @default.
- W3170394628 cites W2071024610 @default.
- W3170394628 cites W2071536472 @default.
- W3170394628 cites W2073799274 @default.
- W3170394628 cites W2076344205 @default.
- W3170394628 cites W2086495376 @default.
- W3170394628 cites W2088694143 @default.
- W3170394628 cites W2098550556 @default.
- W3170394628 cites W2103373741 @default.
- W3170394628 cites W2104155452 @default.
- W3170394628 cites W2108981555 @default.
- W3170394628 cites W2111957326 @default.
- W3170394628 cites W2114346603 @default.
- W3170394628 cites W2116003123 @default.
- W3170394628 cites W2116152046 @default.
- W3170394628 cites W2116255206 @default.
- W3170394628 cites W2118582599 @default.
- W3170394628 cites W2118719937 @default.
- W3170394628 cites W2123431154 @default.
- W3170394628 cites W2123589864 @default.
- W3170394628 cites W2130187979 @default.
- W3170394628 cites W2131790216 @default.
- W3170394628 cites W2132150859 @default.
- W3170394628 cites W2133465432 @default.
- W3170394628 cites W2135985845 @default.
- W3170394628 cites W2136057690 @default.
- W3170394628 cites W2138419072 @default.
- W3170394628 cites W2141459724 @default.
- W3170394628 cites W2144037754 @default.
- W3170394628 cites W2148969844 @default.
- W3170394628 cites W2151135161 @default.
- W3170394628 cites W2151199043 @default.
- W3170394628 cites W2155620350 @default.
- W3170394628 cites W2158625734 @default.
- W3170394628 cites W2158698427 @default.
- W3170394628 cites W2162284422 @default.