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- W3170396962 abstract "• We prepared gold nanorods (GNR) electrostatically coated with chondroitin sulfate A. • The GNR-based medicine (GNR-CS) was efficiently taken up by melanoma cells. • Near-infrared light irradiation induced cell death of melanoma treated with GNR-CS. • GNR-CS would serve as a photothermal therapeutic agent against melanoma. The application of gold nanorods (GNRs) in photothermal therapy is a promising avenue for cancer treatment. The aim of this study was to develop a GNR-based targeted photothermal therapy for melanoma. We utilized the electrostatic interaction between cationic GNRs and an anionic polymer chondroitin sulfate A (CSA), which has an affinity for binding to melanoma cells, to construct an anionic binary GNR-CSA complex (GNR-CS) at an optimal theoretical charge ratio of the trimethylammonium groups of GNR: carboxyl and sulfate groups of CSA = 1:2.5. The cytotoxicity to normal cells and erythrocyte agglutination activity of GNR-CS were evaluated. After the cellular uptake of GNR-CS by melanoma cells (B16-F10) was investigated, the photothermal performance of GNR-CS against B16-F10 cells was evaluated in vitro . The particle size and zeta potential of GNR-CS were approximately 35 nm and -20 mV, respectively. GNR-CS showed little cytotoxicity to normal cells and low erythrocyte agglutination activity, indicating good biocompatibility. Compared with negatively-charged GNR, GNR-CS was highly taken up by B16-F10 cells even if it was negatively charged. Cellular uptake was significantly suppressed upon treatment with excess CSA, suggesting the involvement of a CSA-specific uptake pathway. Furthermore, irradiation of the GNR-CS solution with near-infrared (NIR) light increased its temperature in light-intensity and GNR-concentration dependent manners. GNR-CS exhibited significant and GNR-dose dependent cytotoxicity in melanoma cells in combination with NIR light irradiation. GNRs coated with CSA have the potential as a medicine in targeted photothermal therapy for melanoma." @default.
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- W3170396962 date "2021-09-01" @default.
- W3170396962 modified "2023-10-18" @default.
- W3170396962 title "Electrostatically self-assembled gold nanorods with chondroitin sulfate for targeted photothermal therapy for melanoma" @default.
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- W3170396962 doi "https://doi.org/10.1016/j.pdpdt.2021.102402" @default.
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