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- W3170402771 endingPage "204062232110159" @default.
- W3170402771 startingPage "204062232110159" @default.
- W3170402771 abstract "The parathyroid glands, one of the last organs to be discovered, are responsible for maintaining calcium homeostasis, and they continue to present the clinician with diagnostic and management challenges that are reviewed herein. Primary hyperparathyroidism (PHPT) comprises the vast majority of pathology of the parathyroid glands. The classic variant, presenting with elevated calcium and parathyroid hormone levels, has been studied extensively, but the current body of literature has added to our understanding of normocalcemic and normohormonal variants of PHPT, as well as syndromic forms of PHPT. All variants can lead to bone loss, kidney stones, declining renal function, and a variety of neurocognitive, gastrointestinal, and musculoskeletal complaints, although the majority of PHPT today is asymptomatic. Surgery remains the definitive treatment for PHPT, and advances in screening, evolving indications for surgery, new imaging modalities, and improvements in intra-operative methods have greatly changed the landscape. Surgery continues to produce excellent results in the hands of an experienced parathyroid surgeon. For those patients who are not candidates for surgery, therapeutic advances in medical management allow for improved control of the hypercalcemic state. Parathyroid cancer is extremely rare; the diagnosis is often made intra-operatively or on final pathology, and recurrence is common. The mainstay of treatment is normalization of serum calcium via surgery and medical adjuncts." @default.
- W3170402771 created "2021-06-22" @default.
- W3170402771 creator A5024304733 @default.
- W3170402771 date "2021-01-01" @default.
- W3170402771 modified "2023-10-11" @default.
- W3170402771 title "Advances in the diagnosis and the management of primary hyperparathyroidism" @default.
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- W3170402771 doi "https://doi.org/10.1177/20406223211015965" @default.
- W3170402771 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8202248" @default.
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- W3170402771 hasPublicationYear "2021" @default.
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