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- W3170428504 abstract "A hypofractionated approach has several theoretical advantages in comparison with single-fraction radiosurgery. Hypofractionating treatment promotes the transition of cells from radioresistant cell cycle phases to more sensitive phases. Additionally, resection cavities may be relatively hypoxic, reducing production of oxygen-based free radicals during irradiation that induce the DNA breaks that ultimately cause cell death. This premise, known as the oxygen enhancement ratio, was a fundamental supporting premise of preoperative stereotactic radiosurgery (SRS) trials reducing definitive dosing by 20% compared to those used for post-operative cases. Delivering high radiation doses per fraction in the proximity of various OARs requires accurate patient positioning to ensure treatment efficacy and safety. A frameless treatment technique using a thermoplastic immobilization mask that enables a reproducible setup in combination with image guidance will provide the high precision that is ideal for an HSRS approach." @default.
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- W3170428504 date "2021-05-28" @default.
- W3170428504 modified "2023-09-25" @default.
- W3170428504 title "Principles of Image-Guided Hypofractionated Stereotactic Radiosurgery for Brain Tumors" @default.
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- W3170428504 doi "https://doi.org/10.1201/9781003037095-7" @default.
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