FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3170429307> ?p ?o ?g. }

• W3170429307 abstract "Abstract The breadth of animal hosts that are susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and may serve as reservoirs for continued viral transmission are not known entirely. In August 2020, an outbreak of SARS-CoV-2 occurred in multiple mink farms in Utah and was associated with high mink mortality and rapid viral transmission between animals. The outbreak’s epidemiology, pathology, molecular characterization, and tissue distribution of virus within infected mink is provided. Infection of mink was likely by reverse zoonosis. Once established, infection spread rapidly between independently housed animals and farms, and caused severe respiratory disease and death. Clinical signs were most notably sudden death, anorexia, and increased respiratory effort. Gross pathology examination revealed severe pulmonary congestion and edema. Microscopically there was pulmonary edema with moderate vasculitis, perivasculitis, and fibrinous interstitial pneumonia. Reverse transcriptase polymerase chain reaction (RT-PCR) of tissues collected at necropsy demonstrated the presence of SARS-CoV-2 viral RNA in multiple organs including nasal turbinates, lung, tracheobronchial lymph node, epithelial surfaces, and others. Whole genome sequencing from multiple mink was consistent with published SARS-CoV-2 genomes with few polymorphisms. The Utah mink SARS-CoV-2 strain fell into Clade GH, which is unique among mink and other animal strains sequenced to date and did not share other spike RBD mutations Y453F and F486L found in mink. Localization of viral RNA by in situ hybridization revealed a more localized infection, particularly of the upper respiratory tract. Mink in the outbreak reported herein had high levels of virus in the upper respiratory tract associated with mink-to-mink transmission in a confined housing environment and were particularly susceptible to disease and death due to SARS-CoV-2 infection. Author Summary The recent emergence and worldwide spread of the novel coronavirus has resulted in worldwide disease and economic hardship. The virus, known as SARS-CoV-2 is believed to have originated in bats and has spread worldwide through human-to-human virus transmission. It remains unclear which animal species, other than humans, may also be susceptible to viral infection and could naturally transmit the virus to susceptible hosts. In this study, we describe an outbreak of disease and death due to SARS-CoV-2 infection in farmed mink in Utah, United States. The investigation reveals that mink can spread the virus rapidly between animals and that the disease in mink is due to the viral infection and damage to tissues of the upper and lower respiratory system. The determination that mink are susceptible to SARS-CoV-2 indicates the need for strict biosecurity measures on mink farms to remediate mink-to-mink and human-to-mink transmission for the protection of mink, as well as prevent potential transmission from mink to humans." @default.
• W3170429307 created "2021-06-22" @default.
• W3170429307 creator A5017030604 @default.
• W3170429307 creator A5033488647 @default.
• W3170429307 creator A5033892408 @default.
• W3170429307 creator A5040273103 @default.
• W3170429307 creator A5045734979 @default.
• W3170429307 creator A5057167820 @default.
• W3170429307 creator A5067954587 @default.
• W3170429307 creator A5078002615 @default.
• W3170429307 creator A5078165255 @default.
• W3170429307 creator A5087249664 @default.
• W3170429307 date "2021-06-10" @default.
• W3170429307 modified "2023-10-05" @default.
• W3170429307 title "An outbreak of SARS-CoV-2 with high mortality in mink (<i>Neovison vison</i>) on multiple Utah farms" @default.
• W3170429307 cites W1976741900 @default.
• W3170429307 cites W2005579823 @default.
• W3170429307 cites W2024845268 @default.
• W3170429307 cites W2025170735 @default.
• W3170429307 cites W2029293367 @default.
• W3170429307 cites W2057172638 @default.
• W3170429307 cites W2089797630 @default.
• W3170429307 cites W2143420602 @default.
• W3170429307 cites W2166867592 @default.
• W3170429307 cites W2171157147 @default.
• W3170429307 cites W3001118548 @default.
• W3170429307 cites W3001195213 @default.
• W3170429307 cites W3004026249 @default.
• W3170429307 cites W3004280078 @default.
• W3170429307 cites W3004318991 @default.
• W3170429307 cites W3008394341 @default.
• W3170429307 cites W3012344554 @default.
• W3170429307 cites W3013314797 @default.
• W3170429307 cites W3014233146 @default.
• W3170429307 cites W3014989892 @default.
• W3170429307 cites W3016273199 @default.
• W3170429307 cites W3024382268 @default.
• W3170429307 cites W3025271273 @default.
• W3170429307 cites W3025871232 @default.
• W3170429307 cites W3027918021 @default.
• W3170429307 cites W3034813444 @default.
• W3170429307 cites W3039680806 @default.
• W3170429307 cites W3040980064 @default.
• W3170429307 cites W3043405722 @default.
• W3170429307 cites W3044008199 @default.
• W3170429307 cites W3044050539 @default.
• W3170429307 cites W3046963037 @default.
• W3170429307 cites W3080212501 @default.
• W3170429307 cites W3080316954 @default.
• W3170429307 cites W3080515680 @default.
• W3170429307 cites W3081684714 @default.
• W3170429307 cites W3087124971 @default.
• W3170429307 cites W3091642497 @default.
• W3170429307 cites W3091940401 @default.
• W3170429307 cites W3092539106 @default.
• W3170429307 cites W3102258632 @default.
• W3170429307 cites W3103205625 @default.
• W3170429307 cites W3104695222 @default.
• W3170429307 cites W3114367732 @default.
• W3170429307 cites W3116409048 @default.
• W3170429307 doi "https://doi.org/10.1101/2021.06.09.447754" @default.
• W3170429307 hasPublicationYear "2021" @default.
• W3170429307 type Work @default.
• W3170429307 sameAs 3170429307 @default.
• W3170429307 citedByCount "4" @default.
• W3170429307 countsByYear W31704293072022 @default.
• W3170429307 countsByYear W31704293072023 @default.
• W3170429307 crossrefType "posted-content" @default.
• W3170429307 hasAuthorship W3170429307A5017030604 @default.
• W3170429307 hasAuthorship W3170429307A5033488647 @default.
• W3170429307 hasAuthorship W3170429307A5033892408 @default.
• W3170429307 hasAuthorship W3170429307A5040273103 @default.
• W3170429307 hasAuthorship W3170429307A5045734979 @default.
• W3170429307 hasAuthorship W3170429307A5057167820 @default.
• W3170429307 hasAuthorship W3170429307A5067954587 @default.
• W3170429307 hasAuthorship W3170429307A5078002615 @default.
• W3170429307 hasAuthorship W3170429307A5078165255 @default.
• W3170429307 hasAuthorship W3170429307A5087249664 @default.
• W3170429307 hasBestOaLocation W31704293071 @default.
• W3170429307 hasConcept C116675565 @default.
• W3170429307 hasConcept C126322002 @default.
• W3170429307 hasConcept C142724271 @default.
• W3170429307 hasConcept C159047783 @default.
• W3170429307 hasConcept C18903297 @default.
• W3170429307 hasConcept C2777648638 @default.
• W3170429307 hasConcept C2777714996 @default.
• W3170429307 hasConcept C2779134260 @default.
• W3170429307 hasConcept C2780754187 @default.
• W3170429307 hasConcept C2909621147 @default.
• W3170429307 hasConcept C2910378429 @default.
• W3170429307 hasConcept C3008058167 @default.
• W3170429307 hasConcept C524204448 @default.
• W3170429307 hasConcept C71924100 @default.
• W3170429307 hasConcept C86803240 @default.
• W3170429307 hasConcept C9418649 @default.
• W3170429307 hasConceptScore W3170429307C116675565 @default.
• W3170429307 hasConceptScore W3170429307C126322002 @default.
• W3170429307 hasConceptScore W3170429307C142724271 @default.
• W3170429307 hasConceptScore W3170429307C159047783 @default.
• W3170429307 hasConceptScore W3170429307C18903297 @default.

• next