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- W3170454817 endingPage "0705" @default.
- W3170454817 startingPage "mbc.E20" @default.
- W3170454817 abstract "The baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV), a pathogen of lepidopteran insects, has a striking dependence on the host cell actin cytoskeleton. During the delayed-early stage of infection, AcMNPV was shown to induce the accumulation of actin at the cortex of infected cells. However, the dynamics and molecular mechanism of cortical actin assembly remained unknown. Here, we show that AcMNPV induces dynamic cortical clusters of dot-like actin structures that mediate degradation of the underlying extracellular matrix and therefore function similarly to clusters of invadosomes in mammalian cells. Furthermore, we find that the AcMNPV protein actin-rearrangement-inducing factor-1 (ARIF-1), which was previously shown to be necessary and sufficient for cortical actin assembly and efficient viral infection in insect hosts, is both necessary and sufficient for invadosome formation. We mapped the sequences within the C-terminal cytoplasmic region of ARIF-1 that are required for invadosome formation and identified individual tyrosine and proline residues that are required for organizing these structures. Additionally, we found that ARIF-1 and the invadosome-associated proteins cortactin and the Arp2/3 complex localize to invadosomes and Arp2/3 complex is required for their formation. These ARIF-1-induced invadosomes may be important for the function of ARIF-1 in systemic virus spread." @default.
- W3170454817 created "2021-06-22" @default.
- W3170454817 creator A5030857978 @default.
- W3170454817 creator A5041986810 @default.
- W3170454817 creator A5046526142 @default.
- W3170454817 creator A5080439702 @default.
- W3170454817 date "2021-06-16" @default.
- W3170454817 modified "2023-10-03" @default.
- W3170454817 title "Baculovirus actin-rearrangement-inducing factor ARIF-1 induces the formation of dynamic invadosome clusters" @default.
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- W3170454817 doi "https://doi.org/10.1091/mbc.e20-11-0705" @default.
- W3170454817 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8351737" @default.
- W3170454817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34133213" @default.
- W3170454817 hasPublicationYear "2021" @default.
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