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- W3170476798 abstract "In native tissue, cell-secreted extracellular molecules form the supporting extracellular matrix (ECM) to the cells that provides structural and biochemical signals to the cells. Natural ECM is a nanocomposite made of collagen nanofibers in gels of polysaccharides. Since cells actively sense their microenvironment and react to the properties of their surroundings, nanocomposite scaffolds made of nanofiber meshes embedded in the hydrogel matrix have been developed to closely mimic the natural ECM of cells. These nanocomposite scaffolds proved to give the synergistic benefit of nanofibers and hydrogels in terms of mechanical property, porosity, and cell infiltration. Different approaches like simultaneous electrospinning and electrospraying, layer-by-layer assembly of nanofibers and hydrogels, and mixing of chopped nanofibers in the hydrogel are tested to form 3D nanocomposite scaffolds for tissue engineering. The tunable mechanical property of these nanocomposites proved its advantage for engineering and regeneration of various tissues including cartilage, bone, spinal tissue, ligament, skin, as well as drug delivery carriers. Considering its significance, this chapter elaborates on development, characterization, and application of nanofiber-integrated hydrogel as nanocomposite scaffolds for tissue engineering." @default.
- W3170476798 created "2021-06-22" @default.
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- W3170476798 date "2021-01-01" @default.
- W3170476798 modified "2023-10-16" @default.
- W3170476798 title "Nanofiber-integrated hydrogel as nanocomposites for tissue engineering" @default.
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- W3170476798 doi "https://doi.org/10.1016/b978-0-12-821280-6.00016-7" @default.
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