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- W3170482104 abstract "Tumor breakthrough is driven by genetic or epigenetic variations which assist in initiation, migration, invasion and metastasis of tumors. Astrocyte elevated gene-1 (AEG-1) protein has risen recently as the crucial factor in malignancies and plays a potential role in diverse complex oncogenic signaling cascades. AEG-1 has multiple roles in tumor growth and development and is found to be involved in various signaling pathways of: (i) Ha-ras and PI3K/AKT; (ii) the NF-κB; (iii) the ERK or mitogen-activated protein kinase and Wnt or β-catenin and (iv) the Aurora-A kinase. Recent studies have confirmed that in all the hallmarks of cancers, AEG-1 plays a key functionality including progression, transformation, sustained angiogenesis, evading apoptosis, and invasion and metastasis. Clinical studies have supported that AEG-1 is actively intricated in tumor growth and progression which includes esophageal squamous cell, gastric, colorectal, hepatocellular, gallbladder, breast, prostate and non-small cell lung cancers, as well as renal cell carcinomas, melanoma, glioma, neuroblastoma and osteosarcoma. Existing studies have reported that AEG-1 expression has been induced by Ha-ras through intrication of PI3K/AKT signaling. Conversely, AEG-1 also activates PI3K/AKT pathway and modulates the defined subset of downstream target proteins via crosstalk between the PI3K/AKT/mTOR and Hedgehog signaling cascade which further plays a crucial role in metastasis. Thus, AEG-1 may be employed as a biomarker to discern the patients of those who are likely to get aid from AEG-1-targeted medication. AEG-1 may play as an effective target to repress tumor development, occlude metastasis, and magnify the effectiveness of treatments. In this review, we focus on the molecular mechanism of AEG-1 in the process of carcinogenesis and its involvement in regulation of crosstalk between the PI3K/AKT/mTOR and Hedgehog signaling. We also highlight the multifaceted functions, expression, clinicopathological significance and molecular inhibitors of AEG-1 in various cancer types." @default.
- W3170482104 created "2021-06-22" @default.
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- W3170482104 date "2021-06-15" @default.
- W3170482104 modified "2023-10-17" @default.
- W3170482104 title "Emerging Role and Clinicopathological Significance of AEG-1 in Different Cancer Types: A Concise Review" @default.
- W3170482104 cites W138660494 @default.
- W3170482104 cites W1466030670 @default.
- W3170482104 cites W1479824021 @default.
- W3170482104 cites W1538505873 @default.
- W3170482104 cites W1548210425 @default.
- W3170482104 cites W1573363574 @default.
- W3170482104 cites W1721432590 @default.
- W3170482104 cites W1803954903 @default.
- W3170482104 cites W183454183 @default.
- W3170482104 cites W1887864812 @default.
- W3170482104 cites W1964350129 @default.
- W3170482104 cites W1965568759 @default.
- W3170482104 cites W1967251435 @default.
- W3170482104 cites W1969875009 @default.
- W3170482104 cites W1971207111 @default.
- W3170482104 cites W1972959587 @default.
- W3170482104 cites W1973015093 @default.
- W3170482104 cites W1976134037 @default.
- W3170482104 cites W1979534618 @default.
- W3170482104 cites W1980076720 @default.
- W3170482104 cites W1980492913 @default.
- W3170482104 cites W1981711832 @default.
- W3170482104 cites W1981909450 @default.
- W3170482104 cites W1986075148 @default.
- W3170482104 cites W1986266121 @default.
- W3170482104 cites W1987792229 @default.
- W3170482104 cites W1988298659 @default.
- W3170482104 cites W1988946896 @default.
- W3170482104 cites W1991045401 @default.
- W3170482104 cites W1992223951 @default.
- W3170482104 cites W1996118868 @default.
- W3170482104 cites W1996298926 @default.
- W3170482104 cites W1996497073 @default.
- W3170482104 cites W1998836974 @default.
- W3170482104 cites W1999500450 @default.
- W3170482104 cites W1999543808 @default.
- W3170482104 cites W2000378520 @default.
- W3170482104 cites W2001519284 @default.
- W3170482104 cites W2003752694 @default.
- W3170482104 cites W2003818059 @default.
- W3170482104 cites W2004102172 @default.
- W3170482104 cites W2005328929 @default.
- W3170482104 cites W2006903833 @default.
- W3170482104 cites W2008364361 @default.
- W3170482104 cites W2009295603 @default.
- W3170482104 cites W2009871291 @default.
- W3170482104 cites W2012260193 @default.
- W3170482104 cites W2015774542 @default.
- W3170482104 cites W2016162236 @default.
- W3170482104 cites W2017611603 @default.
- W3170482104 cites W2019256926 @default.
- W3170482104 cites W2020243489 @default.
- W3170482104 cites W2020680441 @default.
- W3170482104 cites W2026147554 @default.
- W3170482104 cites W2029962300 @default.
- W3170482104 cites W2032303618 @default.
- W3170482104 cites W2032672256 @default.
- W3170482104 cites W2036231601 @default.
- W3170482104 cites W2036396908 @default.
- W3170482104 cites W2037190116 @default.
- W3170482104 cites W2039748625 @default.
- W3170482104 cites W2043395027 @default.
- W3170482104 cites W2045432050 @default.
- W3170482104 cites W2048900823 @default.
- W3170482104 cites W2051430639 @default.
- W3170482104 cites W2051584220 @default.
- W3170482104 cites W2053164428 @default.
- W3170482104 cites W2058148459 @default.
- W3170482104 cites W2058908426 @default.
- W3170482104 cites W2061652166 @default.
- W3170482104 cites W2061849670 @default.
- W3170482104 cites W2064336610 @default.
- W3170482104 cites W2065027922 @default.
- W3170482104 cites W2066155423 @default.
- W3170482104 cites W2067129719 @default.
- W3170482104 cites W2067193691 @default.
- W3170482104 cites W2067533256 @default.
- W3170482104 cites W2068111306 @default.
- W3170482104 cites W2069151706 @default.
- W3170482104 cites W2070627423 @default.
- W3170482104 cites W2081733368 @default.
- W3170482104 cites W2082199233 @default.
- W3170482104 cites W2085225921 @default.
- W3170482104 cites W2094722980 @default.
- W3170482104 cites W2094813728 @default.