FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3170482403> ?p ?o ?g. }

• W3170482403 abstract "Abstract Background: Global mortality related to sepsis remains unacceptably high in intensive care units (ICUs). Accurate prognostic evaluation of sepsis could effectively reduce the mortality of septic patients. Our goal is to present an effective and rapid method to assess the prognosis of sepsis. Methods: We included 96 septic patients according to the sepsis 3.0 in ICU, who were grouped into survival and death groups according to 28-day, hospital, and 90-day prognosis. Liquid chromatography/mass spectrometry was performed to detect the metabolite changes in plasma. Multivariate logistic regression models, using differential metabolites and clinical indicators within 24 h after diagnosis of sepsis, were used to construct the prediction models for 28-day, hospital, and 90-day prognosis in sepsis. Results: Metabolic profiles related to 28-day, hospital, and 90-day prognosis were significantly different between the survival and the death group. Specifically, 13, 4, and 29 primary differential metabolites related to amino acid metabolism and fatty acid metabolism were identified between the survival and death group at 28-day, hospital, and 90-day prognosis, respectively. Further, we found that model 1 including indoleacetic acid, 3-methylene-indolenine, heart rate, respiratory support, and application of pressure drugs; model 2 including lymphocyte count, alkaline phosphatase, SOFA, and L-alpha-amino-1H-pyrrole-1-hexanoic acid; model 3 including pyrrolidine, dopamine, heart rate, respiratory support, and application of pressure drugs, could predict 28-day, hospital, and 90-day prognosis of sepsis with a sensitivity of 75.51%, 73.58%, and 83.33%, specificity of 78.72%, 72.09%, and 76.19%, the area under the receiver operating characteristics curve of 0.881, 0.830, 0.892, respectively. Conclusions: This research could be used to predict the 28-day, hospital, and 90-day prognosis of septic patients based on differential metabolites and clinical parameters, and could also be used to develop novel sepsis-treatment methods." @default.
• W3170482403 created "2021-06-22" @default.
• W3170482403 creator A5002486502 @default.
• W3170482403 creator A5014183774 @default.
• W3170482403 creator A5024378134 @default.
• W3170482403 creator A5026126152 @default.
• W3170482403 creator A5026616591 @default.
• W3170482403 creator A5031115326 @default.
• W3170482403 creator A5035776006 @default.
• W3170482403 creator A5043443688 @default.
• W3170482403 creator A5046454314 @default.
• W3170482403 creator A5060939677 @default.
• W3170482403 creator A5067142874 @default.
• W3170482403 creator A5090014574 @default.
• W3170482403 date "2021-06-02" @default.
• W3170482403 modified "2023-09-27" @default.
• W3170482403 title "Construction of the Metabolomics-Based Prognosis-Prediction Models for ICU Septic Patients" @default.
• W3170482403 doi "https://doi.org/10.21203/rs.3.rs-571120/v1" @default.
• W3170482403 hasPublicationYear "2021" @default.
• W3170482403 type Work @default.
• W3170482403 sameAs 3170482403 @default.
• W3170482403 citedByCount "0" @default.
• W3170482403 crossrefType "posted-content" @default.
• W3170482403 hasAuthorship W3170482403A5002486502 @default.
• W3170482403 hasAuthorship W3170482403A5014183774 @default.
• W3170482403 hasAuthorship W3170482403A5024378134 @default.
• W3170482403 hasAuthorship W3170482403A5026126152 @default.
• W3170482403 hasAuthorship W3170482403A5026616591 @default.
• W3170482403 hasAuthorship W3170482403A5031115326 @default.
• W3170482403 hasAuthorship W3170482403A5035776006 @default.
• W3170482403 hasAuthorship W3170482403A5043443688 @default.
• W3170482403 hasAuthorship W3170482403A5046454314 @default.
• W3170482403 hasAuthorship W3170482403A5060939677 @default.
• W3170482403 hasAuthorship W3170482403A5067142874 @default.
• W3170482403 hasAuthorship W3170482403A5090014574 @default.
• W3170482403 hasBestOaLocation W31704824031 @default.
• W3170482403 hasConcept C126322002 @default.
• W3170482403 hasConcept C151956035 @default.
• W3170482403 hasConcept C179755657 @default.
• W3170482403 hasConcept C2777465075 @default.
• W3170482403 hasConcept C2778384902 @default.
• W3170482403 hasConcept C71924100 @default.
• W3170482403 hasConceptScore W3170482403C126322002 @default.
• W3170482403 hasConceptScore W3170482403C151956035 @default.
• W3170482403 hasConceptScore W3170482403C179755657 @default.
• W3170482403 hasConceptScore W3170482403C2777465075 @default.
• W3170482403 hasConceptScore W3170482403C2778384902 @default.
• W3170482403 hasConceptScore W3170482403C71924100 @default.
• W3170482403 hasLocation W31704824031 @default.
• W3170482403 hasOpenAccess W3170482403 @default.
• W3170482403 hasPrimaryLocation W31704824031 @default.
• W3170482403 hasRelatedWork W2083506865 @default.
• W3170482403 hasRelatedWork W2185467061 @default.
• W3170482403 hasRelatedWork W2355167787 @default.
• W3170482403 hasRelatedWork W2617843866 @default.
• W3170482403 hasRelatedWork W2620311811 @default.
• W3170482403 hasRelatedWork W2734946164 @default.
• W3170482403 hasRelatedWork W2952580254 @default.
• W3170482403 hasRelatedWork W2981631641 @default.
• W3170482403 hasRelatedWork W3027548201 @default.
• W3170482403 hasRelatedWork W4366283080 @default.
• W3170482403 isParatext "false" @default.
• W3170482403 isRetracted "false" @default.
• W3170482403 magId "3170482403" @default.
• W3170482403 workType "article" @default.