FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3170492065> ?p ?o ?g. }

• W3170492065 abstract "In transplantation, plasmapheresis and IVIg provide the mainstay of treatment directed at reducing or removing circulating donor-specific antibody (DSA), yet both have limitations. We sought to test the efficacy of targeting the IgG recycling mechanism of the neonatal Fc receptor (FcRn) using anti-FcRn mAb therapy in a sensitized non-human primate (NHP) model, as a pharmacological means of lowering DSA.Six (6) rhesus macaque monkeys, previously sensitized by skin transplantation, received a single dose of 30mg/kg anti-RhFcRn IV, and effects on total IgG, as well as DSA IgG, were measured, in addition to IgM and protective immunity. Subsequently, 60mg/kg IV was given in the setting of kidney transplantation from skin graft donors. Kidney transplant recipients received RhATG, and tacrolimus, MMF, and steroid for maintenance immunosuppression.Circulating total IgG was reduced from a baseline 100% on D0 to 32.0% (mean, SD ± 10.6) on d4 post infusion (p<0.05), while using a DSA assay. T-cell flow cross match (TFXM) was reduced to 40.6±12.5% of baseline, and B-cell FXCM to 52.2±19.3%. Circulating total IgM and DSA IgM were unaffected by treatment. Pathogen-specific antibodies (anti-gB and anti-tetanus toxin IgG) were significantly reduced for 14d post infusion. Post-transplant, circulating IgG responded to anti-FcRn mAb treatment, but DSA increased rapidly.Targeting the FcRn-mediated recycling of IgG is an effective means of lowering circulating donor-specific IgG in the sensitized recipient, although in the setting of organ transplantation mechanisms of rapid antibody rise post-transplant remains unaffected." @default.
• W3170492065 created "2021-06-22" @default.
• W3170492065 creator A5007319566 @default.
• W3170492065 creator A5017548829 @default.
• W3170492065 creator A5029981005 @default.
• W3170492065 creator A5030923472 @default.
• W3170492065 creator A5034100562 @default.
• W3170492065 creator A5036847708 @default.
• W3170492065 creator A5039369938 @default.
• W3170492065 creator A5041597490 @default.
• W3170492065 creator A5047687780 @default.
• W3170492065 creator A5056389032 @default.
• W3170492065 creator A5056778092 @default.
• W3170492065 creator A5073283527 @default.
• W3170492065 creator A5076696601 @default.
• W3170492065 creator A5078530019 @default.
• W3170492065 date "2021-06-02" @default.
• W3170492065 modified "2023-10-01" @default.
• W3170492065 title "Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model" @default.
• W3170492065 cites W1737600104 @default.
• W3170492065 cites W1777834723 @default.
• W3170492065 cites W1981367546 @default.
• W3170492065 cites W1999458479 @default.
• W3170492065 cites W2014018866 @default.
• W3170492065 cites W2092328931 @default.
• W3170492065 cites W2103609427 @default.
• W3170492065 cites W2109771794 @default.
• W3170492065 cites W2114949839 @default.
• W3170492065 cites W2131708234 @default.
• W3170492065 cites W2162907283 @default.
• W3170492065 cites W2221834647 @default.
• W3170492065 cites W2319477768 @default.
• W3170492065 cites W2461849488 @default.
• W3170492065 cites W2605745489 @default.
• W3170492065 cites W2740266422 @default.
• W3170492065 cites W2774126255 @default.
• W3170492065 cites W2789946756 @default.
• W3170492065 cites W2800511553 @default.
• W3170492065 cites W2808825376 @default.
• W3170492065 cites W2884293145 @default.
• W3170492065 cites W2899777989 @default.
• W3170492065 cites W2901625148 @default.
• W3170492065 cites W2937854937 @default.
• W3170492065 cites W2955629465 @default.
• W3170492065 cites W2969008101 @default.
• W3170492065 cites W2982509938 @default.
• W3170492065 cites W3034410100 @default.
• W3170492065 cites W3082685195 @default.
• W3170492065 cites W3083442625 @default.
• W3170492065 cites W3161313818 @default.
• W3170492065 doi "https://doi.org/10.3389/fimmu.2021.660900" @default.
• W3170492065 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8207189" @default.
• W3170492065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34149698" @default.
• W3170492065 hasPublicationYear "2021" @default.
• W3170492065 type Work @default.
• W3170492065 sameAs 3170492065 @default.
• W3170492065 citedByCount "4" @default.
• W3170492065 countsByYear W31704920652022 @default.
• W3170492065 countsByYear W31704920652023 @default.
• W3170492065 crossrefType "journal-article" @default.
• W3170492065 hasAuthorship W3170492065A5007319566 @default.
• W3170492065 hasAuthorship W3170492065A5017548829 @default.
• W3170492065 hasAuthorship W3170492065A5029981005 @default.
• W3170492065 hasAuthorship W3170492065A5030923472 @default.
• W3170492065 hasAuthorship W3170492065A5034100562 @default.
• W3170492065 hasAuthorship W3170492065A5036847708 @default.
• W3170492065 hasAuthorship W3170492065A5039369938 @default.
• W3170492065 hasAuthorship W3170492065A5041597490 @default.
• W3170492065 hasAuthorship W3170492065A5047687780 @default.
• W3170492065 hasAuthorship W3170492065A5056389032 @default.
• W3170492065 hasAuthorship W3170492065A5056778092 @default.
• W3170492065 hasAuthorship W3170492065A5073283527 @default.
• W3170492065 hasAuthorship W3170492065A5076696601 @default.
• W3170492065 hasAuthorship W3170492065A5078530019 @default.
• W3170492065 hasBestOaLocation W31704920651 @default.
• W3170492065 hasConcept C126322002 @default.
• W3170492065 hasConcept C159654299 @default.
• W3170492065 hasConcept C203014093 @default.
• W3170492065 hasConcept C2778430493 @default.
• W3170492065 hasConcept C2778842783 @default.
• W3170492065 hasConcept C2780252810 @default.
• W3170492065 hasConcept C2780303639 @default.
• W3170492065 hasConcept C2780649865 @default.
• W3170492065 hasConcept C2780898057 @default.
• W3170492065 hasConcept C2909675724 @default.
• W3170492065 hasConcept C2911091166 @default.
• W3170492065 hasConcept C71924100 @default.
• W3170492065 hasConceptScore W3170492065C126322002 @default.
• W3170492065 hasConceptScore W3170492065C159654299 @default.
• W3170492065 hasConceptScore W3170492065C203014093 @default.
• W3170492065 hasConceptScore W3170492065C2778430493 @default.
• W3170492065 hasConceptScore W3170492065C2778842783 @default.
• W3170492065 hasConceptScore W3170492065C2780252810 @default.
• W3170492065 hasConceptScore W3170492065C2780303639 @default.
• W3170492065 hasConceptScore W3170492065C2780649865 @default.
• W3170492065 hasConceptScore W3170492065C2780898057 @default.
• W3170492065 hasConceptScore W3170492065C2909675724 @default.
• W3170492065 hasConceptScore W3170492065C2911091166 @default.
• W3170492065 hasConceptScore W3170492065C71924100 @default.
• W3170492065 hasFunder F4320332161 @default.

• next