Matches in SemOpenAlex for { <https://semopenalex.org/work/W3170495265> ?p ?o ?g. }
- W3170495265 endingPage "106643" @default.
- W3170495265 startingPage "106643" @default.
- W3170495265 abstract "Acute lymphoblastic leukemia (ALL) is one of the most frequent hematological malignancies in children, representing approximately 25 % of all pediatric cancers. Despite striking advances in ALL treatments, a small population of patients does not still respond to chemotherapy, raising the number of deaths in children. ABC transporters are one of the major causes of multidrug resistance (MDR) in cancers and overexpression of ABCA3 is directly associated with increased chemo-resistance in pediatric ALL. Here, we aimed to identify the microRNAs (miRNAs) which may regulate the expression of ABCA3 in childhood ALL. Bone marrow samples from a total of 50 ALLs and 59 controls were collected and after in silico and literature search, miR-324-3p and miR-508-5p were nominated from a list of putative miRNAs targeting ABCA3. Our qPCR analysis showed a low expression profile of selected miRNAs in pediatric ALL patients compared with non-cancer controls. Furthermore, we found that both miR-324-3p and miR-508-5p were significantly differentially expressed between patients with positive and negative minimal residual disease (MRD + vs MRD-) after one year of chemotherapy while only miR-508-5p was underexpressed in relapsed ALL patients. Additionally, a negative correlation was identified between the expression of these two miRNAs and ABCA3, supporting the regulatory effect of them on drug resistance through interacting with ABCA3. Overall, we suggested miR-324-3p and miR-508-5p as potential diagnostic and drug-resistant biomarkers in pediatric ALL. Moreover, our findings presented miR-508-5p to behave as a promising relapsed indicator in childhood ALL which can be applied in the development of novel therapeutic strategies." @default.
- W3170495265 created "2021-06-22" @default.
- W3170495265 creator A5004645871 @default.
- W3170495265 creator A5013380877 @default.
- W3170495265 creator A5027744966 @default.
- W3170495265 creator A5048816716 @default.
- W3170495265 date "2021-10-01" @default.
- W3170495265 modified "2023-09-29" @default.
- W3170495265 title "miR-324-3p and miR-508-5p expression levels could serve as potential diagnostic and multidrug-resistant biomarkers in childhood acute lymphoblastic leukemia" @default.
- W3170495265 cites W1522465334 @default.
- W3170495265 cites W1553345136 @default.
- W3170495265 cites W1981442037 @default.
- W3170495265 cites W1983371018 @default.
- W3170495265 cites W1990061381 @default.
- W3170495265 cites W1996551392 @default.
- W3170495265 cites W2000378868 @default.
- W3170495265 cites W2003631713 @default.
- W3170495265 cites W2031014255 @default.
- W3170495265 cites W2037423947 @default.
- W3170495265 cites W2045477445 @default.
- W3170495265 cites W2051652307 @default.
- W3170495265 cites W2053415059 @default.
- W3170495265 cites W2066024172 @default.
- W3170495265 cites W2071244728 @default.
- W3170495265 cites W2080212337 @default.
- W3170495265 cites W2114340167 @default.
- W3170495265 cites W2116397531 @default.
- W3170495265 cites W2116661471 @default.
- W3170495265 cites W2126283892 @default.
- W3170495265 cites W2134161035 @default.
- W3170495265 cites W2159343208 @default.
- W3170495265 cites W2160087354 @default.
- W3170495265 cites W2214655721 @default.
- W3170495265 cites W2310712575 @default.
- W3170495265 cites W2530096609 @default.
- W3170495265 cites W2555828085 @default.
- W3170495265 cites W2558177455 @default.
- W3170495265 cites W2563001564 @default.
- W3170495265 cites W2625893364 @default.
- W3170495265 cites W2725970815 @default.
- W3170495265 cites W2735806624 @default.
- W3170495265 cites W2766137693 @default.
- W3170495265 cites W2768808463 @default.
- W3170495265 cites W2779191023 @default.
- W3170495265 cites W2903485340 @default.
- W3170495265 cites W2919918774 @default.
- W3170495265 cites W2995803738 @default.
- W3170495265 cites W3008071576 @default.
- W3170495265 cites W3089416490 @default.
- W3170495265 cites W3093388244 @default.
- W3170495265 doi "https://doi.org/10.1016/j.leukres.2021.106643" @default.
- W3170495265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34147937" @default.
- W3170495265 hasPublicationYear "2021" @default.
- W3170495265 type Work @default.
- W3170495265 sameAs 3170495265 @default.
- W3170495265 citedByCount "13" @default.
- W3170495265 countsByYear W31704952652021 @default.
- W3170495265 countsByYear W31704952652022 @default.
- W3170495265 countsByYear W31704952652023 @default.
- W3170495265 crossrefType "journal-article" @default.
- W3170495265 hasAuthorship W3170495265A5004645871 @default.
- W3170495265 hasAuthorship W3170495265A5013380877 @default.
- W3170495265 hasAuthorship W3170495265A5027744966 @default.
- W3170495265 hasAuthorship W3170495265A5048816716 @default.
- W3170495265 hasConcept C104317684 @default.
- W3170495265 hasConcept C114851261 @default.
- W3170495265 hasConcept C121608353 @default.
- W3170495265 hasConcept C126322002 @default.
- W3170495265 hasConcept C133936738 @default.
- W3170495265 hasConcept C143998085 @default.
- W3170495265 hasConcept C145059251 @default.
- W3170495265 hasConcept C2776694085 @default.
- W3170495265 hasConcept C2778461978 @default.
- W3170495265 hasConcept C2779823535 @default.
- W3170495265 hasConcept C2993561819 @default.
- W3170495265 hasConcept C54355233 @default.
- W3170495265 hasConcept C60644358 @default.
- W3170495265 hasConcept C71924100 @default.
- W3170495265 hasConcept C86803240 @default.
- W3170495265 hasConceptScore W3170495265C104317684 @default.
- W3170495265 hasConceptScore W3170495265C114851261 @default.
- W3170495265 hasConceptScore W3170495265C121608353 @default.
- W3170495265 hasConceptScore W3170495265C126322002 @default.
- W3170495265 hasConceptScore W3170495265C133936738 @default.
- W3170495265 hasConceptScore W3170495265C143998085 @default.
- W3170495265 hasConceptScore W3170495265C145059251 @default.
- W3170495265 hasConceptScore W3170495265C2776694085 @default.
- W3170495265 hasConceptScore W3170495265C2778461978 @default.
- W3170495265 hasConceptScore W3170495265C2779823535 @default.
- W3170495265 hasConceptScore W3170495265C2993561819 @default.
- W3170495265 hasConceptScore W3170495265C54355233 @default.
- W3170495265 hasConceptScore W3170495265C60644358 @default.
- W3170495265 hasConceptScore W3170495265C71924100 @default.
- W3170495265 hasConceptScore W3170495265C86803240 @default.
- W3170495265 hasLocation W31704952651 @default.
- W3170495265 hasOpenAccess W3170495265 @default.
- W3170495265 hasPrimaryLocation W31704952651 @default.
- W3170495265 hasRelatedWork W1977342490 @default.