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- W3170574039 abstract "Studies of cerebral autoregulation are often limited to the middle and anterior cerebral arteries (MCA, ACA) and do not include the vertebral artery (VA). Therefore, it is not well known whether major cerebral arteries differ in their response to sudden changes in arterial blood pressure (ABP) as seen with a postural maneuver. 22 subjects (11 women) performed 3 sit-to-stand maneuvers (Age 29.6±11.5 yrs, Height 172.7±7.5 cm, 75.6±14.9 cm, BMI 25.3±4.2). Cerebral blood flow was recorded continuously (MCA, ACA, VA) along with ABP, end-tidal CO2 and heart rate. We computed an autoregulatory index (ARI) for each artery based on Tiecks et al. (1995) model. We observed a significant main effect for arterial territory (p = 0.003; MCA: 2.6±1.7, ACA: 2.4±1.7; VA: 3.8±2.0). Pairwise comparisons (Bonferonni corrected) indicated that ARI values for the VA were significantly higher than both the MCA (p = 0.002) and ACA (p = 0.002). Our data suggest that based on ARI, the VA exhibits better autoregulation than the MCA or ACA – perhaps reflective of a protective mechanism to ensure adequate blood flow to the brainstem. Future studies should consider the inclusion of the VA into their assessment which may have particular relevance in the evaluation of several clinical disorders including orthostatic intolerance. Work supported by NJ WRIISC." @default.
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- W3170574039 date "2013-04-01" @default.
- W3170574039 modified "2023-09-23" @default.
- W3170574039 title "Effects of Arterial Territory on Dynamic Cerebral Autoregulation" @default.
- W3170574039 doi "https://doi.org/10.1096/fasebj.27.1_supplement.1203.3" @default.
- W3170574039 hasPublicationYear "2013" @default.
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