Matches in SemOpenAlex for { <https://semopenalex.org/work/W3170588478> ?p ?o ?g. }
- W3170588478 abstract "Abstract Lynch syndrome is one of the most common hereditary cancer syndromes and is characterized by the development of many cancers, such as colorectal cancer (CRC), endometrial cancer, ovarian cancer, stomach cancer and many other cancers. Lynch syndrome is caused by pathogenic germline variants in one of four DNA mismatch repair genes (MLH1, MSH2, MSH6, or PMS2) or by an EPCAM deletion. The MLH1 variant is correlated with the highest risk of CRC, while the MSH2 variant is correlated with the highest risk of other cancers. CRC is the most common cancer type that develops in individuals with Lynch syndrome, followed by endometrial cancer. Recent advances have been made to help us further understand the molecular pathogenesis of this disease and help improve diagnostic testing efficiency and surveillance strategies. Moreover, recent advances in immunotherapy provided by clinical trials also provide clinicians with more chances to better treat Lynch syndrome. This study aims to review many advances in the molecular genetics, clinical features, diagnosis, surveillance and treatment of Lynch syndrome." @default.
- W3170588478 created "2021-06-22" @default.
- W3170588478 creator A5056078581 @default.
- W3170588478 creator A5057000014 @default.
- W3170588478 creator A5084539432 @default.
- W3170588478 date "2021-06-12" @default.
- W3170588478 modified "2023-10-16" @default.
- W3170588478 title "Recent advances in Lynch syndrome" @default.
- W3170588478 cites W1940241680 @default.
- W3170588478 cites W1966498049 @default.
- W3170588478 cites W1968357712 @default.
- W3170588478 cites W1970415574 @default.
- W3170588478 cites W1975039405 @default.
- W3170588478 cites W1981831407 @default.
- W3170588478 cites W1989190477 @default.
- W3170588478 cites W1993051520 @default.
- W3170588478 cites W1998970984 @default.
- W3170588478 cites W2003056152 @default.
- W3170588478 cites W2006836472 @default.
- W3170588478 cites W2009052175 @default.
- W3170588478 cites W2025785990 @default.
- W3170588478 cites W2032465462 @default.
- W3170588478 cites W2035178765 @default.
- W3170588478 cites W2035624229 @default.
- W3170588478 cites W2039774169 @default.
- W3170588478 cites W2045044035 @default.
- W3170588478 cites W2057155604 @default.
- W3170588478 cites W2065316325 @default.
- W3170588478 cites W2068906373 @default.
- W3170588478 cites W2080486830 @default.
- W3170588478 cites W2096273854 @default.
- W3170588478 cites W2100692201 @default.
- W3170588478 cites W2101021680 @default.
- W3170588478 cites W2109378245 @default.
- W3170588478 cites W2112424666 @default.
- W3170588478 cites W2116799256 @default.
- W3170588478 cites W2122508619 @default.
- W3170588478 cites W2124896165 @default.
- W3170588478 cites W2127951115 @default.
- W3170588478 cites W2128793721 @default.
- W3170588478 cites W2130222467 @default.
- W3170588478 cites W2131617435 @default.
- W3170588478 cites W2145032084 @default.
- W3170588478 cites W2145297551 @default.
- W3170588478 cites W2152635693 @default.
- W3170588478 cites W2155157454 @default.
- W3170588478 cites W2156299764 @default.
- W3170588478 cites W2157304020 @default.
- W3170588478 cites W2165606389 @default.
- W3170588478 cites W2188312187 @default.
- W3170588478 cites W2191157318 @default.
- W3170588478 cites W2255602917 @default.
- W3170588478 cites W2507377274 @default.
- W3170588478 cites W2545241042 @default.
- W3170588478 cites W2560397825 @default.
- W3170588478 cites W2570702936 @default.
- W3170588478 cites W2595434407 @default.
- W3170588478 cites W2603428872 @default.
- W3170588478 cites W2616335683 @default.
- W3170588478 cites W2729961408 @default.
- W3170588478 cites W2784868445 @default.
- W3170588478 cites W2790613213 @default.
- W3170588478 cites W2791041383 @default.
- W3170588478 cites W2799673550 @default.
- W3170588478 cites W2802141870 @default.
- W3170588478 cites W2885991748 @default.
- W3170588478 cites W2889646458 @default.
- W3170588478 cites W2951438828 @default.
- W3170588478 cites W2975775173 @default.
- W3170588478 cites W2981646551 @default.
- W3170588478 cites W2987318433 @default.
- W3170588478 cites W2987385271 @default.
- W3170588478 cites W3000594265 @default.
- W3170588478 cites W3030387696 @default.
- W3170588478 cites W3047245857 @default.
- W3170588478 cites W3047913937 @default.
- W3170588478 cites W3081720917 @default.
- W3170588478 cites W3087620462 @default.
- W3170588478 cites W3093815538 @default.
- W3170588478 cites W3103907801 @default.
- W3170588478 cites W3119698621 @default.
- W3170588478 cites W4231337390 @default.
- W3170588478 doi "https://doi.org/10.1186/s40164-021-00231-4" @default.
- W3170588478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8199357" @default.
- W3170588478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34118983" @default.
- W3170588478 hasPublicationYear "2021" @default.
- W3170588478 type Work @default.
- W3170588478 sameAs 3170588478 @default.
- W3170588478 citedByCount "20" @default.
- W3170588478 countsByYear W31705884782022 @default.
- W3170588478 countsByYear W31705884782023 @default.
- W3170588478 crossrefType "journal-article" @default.
- W3170588478 hasAuthorship W3170588478A5056078581 @default.
- W3170588478 hasAuthorship W3170588478A5057000014 @default.
- W3170588478 hasAuthorship W3170588478A5084539432 @default.
- W3170588478 hasBestOaLocation W31705884781 @default.
- W3170588478 hasConcept C104317684 @default.
- W3170588478 hasConcept C111425858 @default.
- W3170588478 hasConcept C121608353 @default.
- W3170588478 hasConcept C126322002 @default.