Matches in SemOpenAlex for { <https://semopenalex.org/work/W3170594552> ?p ?o ?g. }
- W3170594552 endingPage "70" @default.
- W3170594552 startingPage "54" @default.
- W3170594552 abstract "Currently, clinical treatment for temozolomide (TMZ)-resistant glioblastoma multiforme (GBM) is still a difficult problem. The aim of this paper is to set up a new GBM-targeted drug delivery system to treat TMZ-resistant GBM. Zoledronate (ZOL) not only induces apoptosis of TMZ-resistant GBM cells by down-regulation of farnesyl pyrophosphate synthetase (FPPS) but also increases the proportion of M1-type GBM associated macrophages (GAM). Based on chemoattractants secreted by GBM cells, a ZOL loaded nanoparticle coated with microglia cell membrane (ZOL@CNPs) was prepared to deliver ZOL to central nervous system to treat TMZ-resistant GBM. ZOL@CNPs was actively recruited to TMZ-resistant GBM region by CX3CL1/CX3CR1 and CSF-1/CSF-1R signal axis, and the release of ZOL from ZOL@CNPs was triggered by glutathione in GBM cells. ZOL@CNPs inhibited the growth of TMZ-resistant GBM through inducing apoptosis and inhibiting the migration and invasion of TMZ-resistant GBM cells. Besides, the immunosuppressive and hypoxic microenvironment, playing an important role in the growth of TMZ-resistant GBM, was significantly improved by ZOL@CNPs through increasing the proportion of M1-type GAM and blocking the expression of HIF-1α. ZOL@CNPs has a great potential application in the treatment for TMZ-resistant GBM." @default.
- W3170594552 created "2021-06-22" @default.
- W3170594552 creator A5010484591 @default.
- W3170594552 creator A5013564891 @default.
- W3170594552 creator A5019685128 @default.
- W3170594552 creator A5055309139 @default.
- W3170594552 creator A5057097862 @default.
- W3170594552 creator A5065937445 @default.
- W3170594552 creator A5081908047 @default.
- W3170594552 creator A5088011583 @default.
- W3170594552 date "2021-08-01" @default.
- W3170594552 modified "2023-10-14" @default.
- W3170594552 title "Chemoattractants driven and microglia based biomimetic nanoparticle treating TMZ-resistant glioblastoma multiforme" @default.
- W3170594552 cites W2003343932 @default.
- W3170594552 cites W2021661404 @default.
- W3170594552 cites W2040857439 @default.
- W3170594552 cites W2053929414 @default.
- W3170594552 cites W2055988323 @default.
- W3170594552 cites W2142051677 @default.
- W3170594552 cites W2143293161 @default.
- W3170594552 cites W2200671523 @default.
- W3170594552 cites W2220215167 @default.
- W3170594552 cites W2571301339 @default.
- W3170594552 cites W2617597517 @default.
- W3170594552 cites W2624969848 @default.
- W3170594552 cites W2727871530 @default.
- W3170594552 cites W2765159648 @default.
- W3170594552 cites W2787870778 @default.
- W3170594552 cites W2791883008 @default.
- W3170594552 cites W2794838235 @default.
- W3170594552 cites W2801897467 @default.
- W3170594552 cites W2803390405 @default.
- W3170594552 cites W2884785743 @default.
- W3170594552 cites W2885518311 @default.
- W3170594552 cites W2887013146 @default.
- W3170594552 cites W2887545848 @default.
- W3170594552 cites W2890798397 @default.
- W3170594552 cites W2898156421 @default.
- W3170594552 cites W2900540194 @default.
- W3170594552 cites W2911255253 @default.
- W3170594552 cites W2915562119 @default.
- W3170594552 cites W2917266686 @default.
- W3170594552 cites W2922088814 @default.
- W3170594552 cites W2936718731 @default.
- W3170594552 cites W2943682720 @default.
- W3170594552 cites W2948231961 @default.
- W3170594552 cites W2953543265 @default.
- W3170594552 cites W2953634981 @default.
- W3170594552 cites W2963932652 @default.
- W3170594552 cites W2968830168 @default.
- W3170594552 cites W2981521201 @default.
- W3170594552 cites W2983134909 @default.
- W3170594552 cites W2987063621 @default.
- W3170594552 cites W2998183983 @default.
- W3170594552 cites W3003366398 @default.
- W3170594552 cites W3009898868 @default.
- W3170594552 cites W3011716704 @default.
- W3170594552 cites W3013092411 @default.
- W3170594552 cites W3016739433 @default.
- W3170594552 cites W3026484222 @default.
- W3170594552 cites W3037170062 @default.
- W3170594552 cites W3041777518 @default.
- W3170594552 cites W3047515231 @default.
- W3170594552 cites W3063660201 @default.
- W3170594552 cites W3081288643 @default.
- W3170594552 cites W3086867618 @default.
- W3170594552 cites W3097646670 @default.
- W3170594552 cites W3098057694 @default.
- W3170594552 cites W3101861808 @default.
- W3170594552 cites W3112965876 @default.
- W3170594552 cites W3116765275 @default.
- W3170594552 cites W3118586537 @default.
- W3170594552 cites W4205669420 @default.
- W3170594552 doi "https://doi.org/10.1016/j.jconrel.2021.06.015" @default.
- W3170594552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34129862" @default.
- W3170594552 hasPublicationYear "2021" @default.
- W3170594552 type Work @default.
- W3170594552 sameAs 3170594552 @default.
- W3170594552 citedByCount "23" @default.
- W3170594552 countsByYear W31705945522021 @default.
- W3170594552 countsByYear W31705945522022 @default.
- W3170594552 countsByYear W31705945522023 @default.
- W3170594552 crossrefType "journal-article" @default.
- W3170594552 hasAuthorship W3170594552A5010484591 @default.
- W3170594552 hasAuthorship W3170594552A5013564891 @default.
- W3170594552 hasAuthorship W3170594552A5019685128 @default.
- W3170594552 hasAuthorship W3170594552A5055309139 @default.
- W3170594552 hasAuthorship W3170594552A5057097862 @default.
- W3170594552 hasAuthorship W3170594552A5065937445 @default.
- W3170594552 hasAuthorship W3170594552A5081908047 @default.
- W3170594552 hasAuthorship W3170594552A5088011583 @default.
- W3170594552 hasBestOaLocation W31705945521 @default.
- W3170594552 hasConcept C185592680 @default.
- W3170594552 hasConcept C203014093 @default.
- W3170594552 hasConcept C2776194525 @default.
- W3170594552 hasConcept C2776914184 @default.
- W3170594552 hasConcept C2777389519 @default.
- W3170594552 hasConcept C2779830541 @default.