FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3170605453> ?p ?o ?g. }

• W3170605453 endingPage "43" @default.
• W3170605453 startingPage "29" @default.
• W3170605453 abstract "Vogt-Koyanagi-Harada (VKH) disease is a primary autoimmune stromal choroiditis. This review aimed to provide a novel perspective of the disease. We took into account recent developments in the understanding of the disease and crucial progress in investigational modalities of the choroid, which has led to new, simpler diagnostic criteria. We analysed recent novel notions in the literature and new diagnostic tools for VKH. We identified the following updates for VKH disease: (1) A crucial differentiation between the acute initial-onset and the chronic forms of the disease; (2) the integration of new, precise imaging methods to assess choroidal inflammation; (3) the promotion of simplified, more reliable diagnostic criteria for acute initial-onset of the disease, based on the sine qua non presence of diffuse choroiditis, detected with indocyanine green angiography (ICGA) and/or Enhanced Depth Imaging OCT (EDI-OCT); and (4) treatment optimisation through early, vigorous, sustained corticosteroid and nonsteroidal immunosuppression, as the first line of treatment for initial-onset VKH disease, and monitoring subclinical choroidal inflammation during follow-ups. Several studies have shown that most patients could discontinue treatment without an inflammation relapse. ICGA and EDI-OCT represented the methods of choice for precisely monitoring disease evolution. Simplified, precise, new diagnostic criteria allow early diagnosis of VKH. In VKH disease, inflammation exclusively originates in the choroidal stroma. Therefore, in many cases, early, sustained treatment, with dual corticosteroid and nonsteroidal immunosuppressive therapy can result in full healing, which obviates chronic, uncontrolled, subclinical choroidal inflammation.摘要: 小柳-原田病 (Vogt-Koyanagi-Harada, VKH) 是一种原发性自身免疫性间质性脉络膜炎。本综述旨在为疾病的诊断与治疗提供一个新的视角。我们将该疾病发病机理的最新进展以及针对脉络膜成像的关键进展进行综合考虑, 提出了新的、更简单的诊断标准。我们对新近文献中的新概念和的VKH诊断手段进行了分析与综合, 总结了VKH疾病的最新进展如下: (1) 急性初发和慢性疾病之间的关键区别; (2) 整合新的、精确的成像方法以评估脉络膜炎症; (3) 以弥漫性脉络膜炎的存在为非必要诊断条件, 通过吲哚青绿血管造影 (indocyanine green angiography, ICGA) 和/或EDI-OCT (Enhanced Depth Imaging OCT, EDI-OCT) 成像技术, 确立简化的、更可靠的疾病急性起病诊断标准; (4) 通过早期、足量、持续的皮质类固醇和非类固醇免疫抑制剂的优化治疗方案, 作为初发VKH的一线治疗, 且在随访期间监测亚临床脉络膜炎症。不少研究均表明, 大多数患者停止治疗后炎症不会复发。ICGA和EDI-OCT是精确测病情的首选方法。新的精确、简化的诊断标准有利于VKH在早期得到诊断。在VKH中, 炎症仅起源于脉络膜基质。因此在许多情况下, 早期、持续、联合皮质类固醇和非类固醇免疫抑制治疗可实现完全“治愈”, 从而避免慢性、不受控制的亚临床脉络膜炎。." @default.
• W3170605453 created "2021-06-22" @default.
• W3170605453 creator A5000294188 @default.
• W3170605453 creator A5005435473 @default.
• W3170605453 creator A5036024286 @default.
• W3170605453 creator A5045478397 @default.
• W3170605453 creator A5056249084 @default.
• W3170605453 creator A5058257194 @default.
• W3170605453 creator A5067156150 @default.
• W3170605453 creator A5075584830 @default.
• W3170605453 creator A5076762153 @default.
• W3170605453 date "2021-06-18" @default.
• W3170605453 modified "2023-10-10" @default.
• W3170605453 title "Precise, simplified diagnostic criteria and optimised management of initial-onset Vogt–Koyanagi–Harada disease: an updated review" @default.
• W3170605453 cites W1005670991 @default.
• W3170605453 cites W1568706174 @default.
• W3170605453 cites W1964702251 @default.
• W3170605453 cites W1982057257 @default.
• W3170605453 cites W1986034079 @default.
• W3170605453 cites W1990051308 @default.
• W3170605453 cites W1996473175 @default.
• W3170605453 cites W2010671048 @default.
• W3170605453 cites W2014817794 @default.
• W3170605453 cites W2015355997 @default.
• W3170605453 cites W2027090790 @default.
• W3170605453 cites W2033626511 @default.
• W3170605453 cites W2034207514 @default.
• W3170605453 cites W2038656400 @default.
• W3170605453 cites W2041010053 @default.
• W3170605453 cites W2043796971 @default.
• W3170605453 cites W2045189742 @default.
• W3170605453 cites W2054858806 @default.
• W3170605453 cites W2058660748 @default.
• W3170605453 cites W2062539456 @default.
• W3170605453 cites W2064095053 @default.
• W3170605453 cites W2065588725 @default.
• W3170605453 cites W2071406464 @default.
• W3170605453 cites W2075332893 @default.
• W3170605453 cites W2076198447 @default.
• W3170605453 cites W2077330797 @default.
• W3170605453 cites W2078880902 @default.
• W3170605453 cites W2079753882 @default.
• W3170605453 cites W2084189709 @default.
• W3170605453 cites W2084296063 @default.
• W3170605453 cites W2092038142 @default.
• W3170605453 cites W2104569386 @default.
• W3170605453 cites W2107964627 @default.
• W3170605453 cites W2125544442 @default.
• W3170605453 cites W2125748950 @default.
• W3170605453 cites W2126019825 @default.
• W3170605453 cites W2126088683 @default.
• W3170605453 cites W2134644689 @default.
• W3170605453 cites W2136795316 @default.
• W3170605453 cites W2137027145 @default.
• W3170605453 cites W2144363971 @default.
• W3170605453 cites W2146881183 @default.
• W3170605453 cites W2151783991 @default.
• W3170605453 cites W2153880301 @default.
• W3170605453 cites W2157293946 @default.
• W3170605453 cites W2158525523 @default.
• W3170605453 cites W2169941091 @default.
• W3170605453 cites W2214287581 @default.
• W3170605453 cites W2222797537 @default.
• W3170605453 cites W2310090962 @default.
• W3170605453 cites W2326716815 @default.
• W3170605453 cites W2334836749 @default.
• W3170605453 cites W2341329109 @default.
• W3170605453 cites W2416612570 @default.
• W3170605453 cites W2417836626 @default.
• W3170605453 cites W2496153328 @default.
• W3170605453 cites W2505812929 @default.
• W3170605453 cites W2510963394 @default.
• W3170605453 cites W2539064830 @default.
• W3170605453 cites W2550288650 @default.
• W3170605453 cites W2605077310 @default.
• W3170605453 cites W2616172332 @default.
• W3170605453 cites W2622667201 @default.
• W3170605453 cites W2742582369 @default.
• W3170605453 cites W2767333827 @default.
• W3170605453 cites W2783645422 @default.
• W3170605453 cites W2797832552 @default.
• W3170605453 cites W2801982519 @default.
• W3170605453 cites W2807769634 @default.
• W3170605453 cites W2837200535 @default.
• W3170605453 cites W2885520241 @default.
• W3170605453 cites W2898415609 @default.
• W3170605453 cites W2904743652 @default.
• W3170605453 cites W2923215486 @default.
• W3170605453 cites W2948501658 @default.
• W3170605453 cites W2978583166 @default.
• W3170605453 cites W2983554154 @default.
• W3170605453 cites W3025454562 @default.
• W3170605453 cites W3086137433 @default.
• W3170605453 cites W3092185369 @default.
• W3170605453 cites W3093276913 @default.
• W3170605453 cites W3124928640 @default.
• W3170605453 cites W78065229 @default.
• W3170605453 doi "https://doi.org/10.1038/s41433-021-01573-3" @default.

• next