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• W3170638352 abstract "The failure to develop analgesic drugs is attributed not only to the complex and diverse pathophysiology of pain in humans but also to the poor experimental design and poor preclinical assessment of pain. Although considerable efforts have been devoted to overcoming the relevant problems, many features of the behavioral pain assessment remain to be characterized. For example, a decreased locomotor activity as a common presentation of pain-like behavior has yet to be described. Studies on mice experimentally induced with carrageenan have provided opportunities to explore pain-related behaviors in automated home-cage monitoring. Through this approach, the locomotor activities of mice with carrageenan-induced inflammatory pain can be precisely and objectively captured. Here, we found that the mobile behaviors of mice reduced, and their immobility increased, indicating that carrageenan induction in mice caused a significant decrease in locomotor activity. These non-reflexive pain behaviors were strongly correlated with the reflexive pain behaviors measured via von Frey and plantar tests. Furthermore, the pharmacological intervention using indomethacin improved the locomotor activity of mice with carrageenan-induced pain. Thus, the analysis of the locomotor activity in automated home-cage monitoring is useful for studying the behavioral analgesia and the pharmacological screening of analgesic drugs. The combined evaluation of reflexive and non-reflexive pain behaviors enhances the translational utility of preclinical pain research in rodents." @default.
• W3170638352 created "2021-06-22" @default.
• W3170638352 creator A5020566447 @default.
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• W3170638352 date "2021-06-10" @default.
• W3170638352 modified "2023-10-14" @default.
• W3170638352 title "Automated home-cage for the evaluation of innate non-reflexive pain behaviors in a mouse model of inflammatory pain" @default.
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• W3170638352 doi "https://doi.org/10.1038/s41598-021-91444-4" @default.
• W3170638352 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8192791" @default.
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• W3170638352 hasPublicationYear "2021" @default.
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