FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3170655872> ?p ?o ?g. }

• W3170655872 abstract "Introduction The integrative physiological response to anemia is complex and incompletely understood. We utilized data from studies of acute anemia in rodents to determine the relationship between changes in blood oxygen content (CaO2) and the heterogenous response of the kidney, heart and brain. We hypothesize that renal hypoxia sensing mechanisms contribute to adaptive physiological responses to maintain cerebral oxygen delivery (DO2) during acute anemia. Methods With animal care committee approval, we synthesized novel and published data from 5 previously published studies. Outcomes included: assessment of the relationship between CaO2 and microvascular renal and brain PO2 (phosphorescence quenching of oxyphor G4); cardiac output (CO) and renal and cerebral blood flow (ultrasound Doppler); hypoxia induced cellular responses (brain and kidney erythropoietin (EPO) mRNA and serum protein levels (ELISA)). Statistical analysis (SigmaPlot 14) was performed by ANOVA, Holm-Sidak and Mann-Whitney rank sum test when appropriate. Significance was assigned at p<0.05. Results In two models of anemia (hemodilution and RBC antibody mediated), acute reductions in blood CaO2 were associated with larger decreases in renal microvascular PO2, relative to brain microvascular PO2 (p<0.05). After acute hemodilution, there was a strong relationship between CaO2 and renal microvascular PO2 (r2=0.75). The magnitude of reduction in renal microvascular PO2 correlated with the degree of renal EPO mRNA expression and serum EPO protein levels. The magnitude of the increase in EPO mRNA was much larger in the kidney than in the brain (p<0.03). While no change in renal blood flow was observed in either model, a significant increase in common carotid and internal carotid blood flow was observed in both models (p<0.012). When DO2 was assessed, the kidney DO2 was reduced at all levels of anemia (p<0.01) whereas brain tissue DO2 was maintained in mild and moderate (Hb 90 and 70 g/L) (p=0.44) anemia but reduced in severe anemia (Hb 50 g/L) (p<0.02). The role of active cardiovascular increases in brain blood flow and maintained DO2 during anemia was impaired by systemic beta blockade, suggesting that active cardiovascular mechanisms are required to maintain optimal brain DO2 during anemia. Discussion Our analysis demonstrated: evidence of quantitative renal PO2 sensing of changes in CaO2; the clamping of renal blood flow (reduced DO2) during anemia may be a central mechanism allowing for sensing of changes in CaO2; reduced arterial CaO2 resulted in a local renal hypoxia response (increased serum EPO) and may have initiated the cardiovascular response to increase cerebral blood flow and maintain cerebral DO2. Inhibition of the adrenergic system impaired these responses and resulted in reduced brain DO2. Understanding the heterogeneous adaptive responses to acute anemia may inform clinical practice and optimize management of acutely anemia patients." @default.
• W3170655872 created "2021-06-22" @default.
• W3170655872 creator A5001507245 @default.
• W3170655872 creator A5006374240 @default.
• W3170655872 creator A5021111163 @default.
• W3170655872 creator A5021638263 @default.
• W3170655872 creator A5030419045 @default.
• W3170655872 creator A5030567035 @default.
• W3170655872 creator A5032954088 @default.
• W3170655872 creator A5037021714 @default.
• W3170655872 creator A5039338588 @default.
• W3170655872 creator A5039781130 @default.
• W3170655872 creator A5054431120 @default.
• W3170655872 creator A5055456256 @default.
• W3170655872 creator A5060475589 @default.
• W3170655872 date "2021-05-01" @default.
• W3170655872 modified "2023-09-27" @default.
• W3170655872 title "Renal Oxygen Sensing Mechanisms May Contribute to Maintaining Cerebral Perfusion During Acute Anemia" @default.
• W3170655872 doi "https://doi.org/10.1096/fasebj.2021.35.s1.04995" @default.
• W3170655872 hasPublicationYear "2021" @default.
• W3170655872 type Work @default.
• W3170655872 sameAs 3170655872 @default.
• W3170655872 citedByCount "0" @default.
• W3170655872 crossrefType "journal-article" @default.
• W3170655872 hasAuthorship W3170655872A5001507245 @default.
• W3170655872 hasAuthorship W3170655872A5006374240 @default.
• W3170655872 hasAuthorship W3170655872A5021111163 @default.
• W3170655872 hasAuthorship W3170655872A5021638263 @default.
• W3170655872 hasAuthorship W3170655872A5030419045 @default.
• W3170655872 hasAuthorship W3170655872A5030567035 @default.
• W3170655872 hasAuthorship W3170655872A5032954088 @default.
• W3170655872 hasAuthorship W3170655872A5037021714 @default.
• W3170655872 hasAuthorship W3170655872A5039338588 @default.
• W3170655872 hasAuthorship W3170655872A5039781130 @default.
• W3170655872 hasAuthorship W3170655872A5054431120 @default.
• W3170655872 hasAuthorship W3170655872A5055456256 @default.
• W3170655872 hasAuthorship W3170655872A5060475589 @default.
• W3170655872 hasConcept C126322002 @default.
• W3170655872 hasConcept C134018914 @default.
• W3170655872 hasConcept C142225936 @default.
• W3170655872 hasConcept C146957229 @default.
• W3170655872 hasConcept C157767197 @default.
• W3170655872 hasConcept C164705383 @default.
• W3170655872 hasConcept C178790620 @default.
• W3170655872 hasConcept C185592680 @default.
• W3170655872 hasConcept C2778248108 @default.
• W3170655872 hasConcept C2778534260 @default.
• W3170655872 hasConcept C2780091579 @default.
• W3170655872 hasConcept C2781073237 @default.
• W3170655872 hasConcept C540031477 @default.
• W3170655872 hasConcept C71924100 @default.
• W3170655872 hasConcept C7836513 @default.
• W3170655872 hasConceptScore W3170655872C126322002 @default.
• W3170655872 hasConceptScore W3170655872C134018914 @default.
• W3170655872 hasConceptScore W3170655872C142225936 @default.
• W3170655872 hasConceptScore W3170655872C146957229 @default.
• W3170655872 hasConceptScore W3170655872C157767197 @default.
• W3170655872 hasConceptScore W3170655872C164705383 @default.
• W3170655872 hasConceptScore W3170655872C178790620 @default.
• W3170655872 hasConceptScore W3170655872C185592680 @default.
• W3170655872 hasConceptScore W3170655872C2778248108 @default.
• W3170655872 hasConceptScore W3170655872C2778534260 @default.
• W3170655872 hasConceptScore W3170655872C2780091579 @default.
• W3170655872 hasConceptScore W3170655872C2781073237 @default.
• W3170655872 hasConceptScore W3170655872C540031477 @default.
• W3170655872 hasConceptScore W3170655872C71924100 @default.
• W3170655872 hasConceptScore W3170655872C7836513 @default.
• W3170655872 hasIssue "S1" @default.
• W3170655872 hasLocation W31706558721 @default.
• W3170655872 hasOpenAccess W3170655872 @default.
• W3170655872 hasPrimaryLocation W31706558721 @default.
• W3170655872 hasRelatedWork W1981626491 @default.
• W3170655872 hasRelatedWork W1983749480 @default.
• W3170655872 hasRelatedWork W1994544696 @default.
• W3170655872 hasRelatedWork W2037340906 @default.
• W3170655872 hasRelatedWork W2104116785 @default.
• W3170655872 hasRelatedWork W2152936658 @default.
• W3170655872 hasRelatedWork W2291468060 @default.
• W3170655872 hasRelatedWork W2404152533 @default.
• W3170655872 hasRelatedWork W2411515276 @default.
• W3170655872 hasRelatedWork W2728083571 @default.
• W3170655872 hasVolume "35" @default.
• W3170655872 isParatext "false" @default.
• W3170655872 isRetracted "false" @default.
• W3170655872 magId "3170655872" @default.
• W3170655872 workType "article" @default.