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- W3170675017 abstract "Abstract Background: We assessed the relationship between AGT gene M235T polymorphism and the susceptibility to cancer by performing an updated meta-analysis. Methods: This study retrospectively searched related articles in the electronic databases. Afterwards, we determined combined odds ratios (ORs) and related 95% confidence intervals (CIs) by the fixed- or random-effects model. Results: The present meta-analysis enrolled altogether 9 articles. On the whole, the relationship between AGT M235T polymorphism and the cancer risk was not significant among the entire population(TT vs MM:OR=1.28,95%CI=0.80-2.04;TM vs MM: OR=0.90, 95%CI = 0.53-1.52;Recessive model: OR= 1.13, 95%CI = 0.83-1.52; Dominant model: OR=0.93, 95%CI =0.55-1.57). But the relationship of AGT M235T polymorphism with the digestive cancer risk was significant upon subgroup analysis stratified according to cancer type (TT vs MM:OR=1.68,95%CI=1.11-2.54;TM vs MM: OR=1.34, 95%CI = 0.97-1.85;Recessive model: OR= 1.27, 95%CI = 0.95-1.70; Dominant model: OR=1.45, 95%CI =1.07-1.96). Conclusion: According to findings in the present meta-analysis, AGT M235T polymorphism may be possibly related to digestive cancer susceptibility." @default.
- W3170675017 created "2021-06-22" @default.
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- W3170675017 creator A5042041866 @default.
- W3170675017 date "2021-06-15" @default.
- W3170675017 modified "2023-09-27" @default.
- W3170675017 title "Associations Between M235T Polymorphism in the AGT Gene and Cancer: An Updated Systematic Review and A Meta-analysis" @default.
- W3170675017 doi "https://doi.org/10.21203/rs.3.rs-592038/v1" @default.
- W3170675017 hasPublicationYear "2021" @default.
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