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• W3170703018 abstract "Nonalcoholic fatty liver disease (NAFLD) is defined by presence of steatosis in more than 5% of liver cells. The gold standard for diagnosis is liver biopsy, but this is seldom achieved due to costs and risk for side effects, and that is why the diagnosis is mostly made based on a combination of radiology and exclusion of other liver diseases. Disease severity staging can be noninvasively achieved with radiological exams such as elastography or blood-based markers that usually have lower sensitivity and specificity. NAFLD is today the most common chronic liver disease globally with a prevalence estimated to be 25%. Fortunately, for many persons NAFLD is an incidental finding with a good prognosis. Whilst a major focus has been on liver-related outcomes in NAFLD, there has recently been an increased interest in extrahepatic consequences of NAFLD. The most commonly studied outcomes include cardiovascular disease and cancer. The risk of adverse outcomes generally differs according to the baseline fibrosis stage. There is a five-time higher risk of liver-related events in NAFLD patients with fibrosis stage 3 as compared to those with no or little fibrosis. Meanwhile, the presence of nonalcoholic steatohepatitis (NASH) does not seem to influence prognosis in addition to fibrosis stage. Patients with NAFLD clearly have a higher risk for cardiovascular outcomes compared to the general population, with a recent meta-analysis indicating a 37% increased hazard for cardiovascular events as opposed to individuals without NAFLD. The risk of liver cancer is increased, which is mostly driven by presence of cirrhosis, but the increased risk is present also in patients without cirrhosis, and to a greater extent than for other chronic liver disease. Around one-third of patients with NAFLD and liver cancer do not have cirrhosis. Additionally, the risk of extrahepatic malignancies is thought to be moderately increased, with most evidence for a link between NAFLD and colorectal cancer where the risk is approximately 50% higher compared to patients without NAFLD. A particularly salient point is if NAFLD can be considered an independent risk factor for outcomes. Many studies have not been able to adjust for key confounders, or suffer from different forms of bias. The clinical problem is nevertheless to identify persons with an increased risk for adverse hepatic and extrahepatic outcomes. We here discuss the evidence linking NAFLD to severe hepatic and extrahepatic outcomes." @default.
• W3170703018 created "2021-06-22" @default.
• W3170703018 creator A5002779497 @default.
• W3170703018 creator A5037227255 @default.
• W3170703018 creator A5058384668 @default.
• W3170703018 date "2021-07-06" @default.
• W3170703018 modified "2023-10-16" @default.
• W3170703018 title "Risk for hepatic and extra‐hepatic outcomes in nonalcoholic fatty liver disease" @default.
• W3170703018 cites W1480578020 @default.
• W3170703018 cites W1514442012 @default.
• W3170703018 cites W1776128289 @default.
• W3170703018 cites W1848828990 @default.
• W3170703018 cites W1851101509 @default.
• W3170703018 cites W1964572117 @default.
• W3170703018 cites W1965389059 @default.
• W3170703018 cites W1966549856 @default.
• W3170703018 cites W1969295126 @default.
• W3170703018 cites W1988823911 @default.
• W3170703018 cites W1989146617 @default.
• W3170703018 cites W1999950621 @default.
• W3170703018 cites W2001837599 @default.
• W3170703018 cites W2017033840 @default.
• W3170703018 cites W2017511982 @default.
• W3170703018 cites W2028705615 @default.
• W3170703018 cites W2030379010 @default.
• W3170703018 cites W2032129662 @default.
• W3170703018 cites W2038831349 @default.
• W3170703018 cites W2043008965 @default.
• W3170703018 cites W2043412879 @default.
• W3170703018 cites W2056337545 @default.
• W3170703018 cites W2060278601 @default.
• W3170703018 cites W2071991978 @default.
• W3170703018 cites W2080998956 @default.
• W3170703018 cites W2085107006 @default.
• W3170703018 cites W2095557106 @default.
• W3170703018 cites W2098629785 @default.
• W3170703018 cites W2110608362 @default.
• W3170703018 cites W2110883868 @default.
• W3170703018 cites W2111946630 @default.
• W3170703018 cites W2129639561 @default.
• W3170703018 cites W2130638724 @default.
• W3170703018 cites W2136305760 @default.
• W3170703018 cites W2145954591 @default.
• W3170703018 cites W2158696981 @default.
• W3170703018 cites W2161883681 @default.
• W3170703018 cites W2165884492 @default.
• W3170703018 cites W2167632576 @default.
• W3170703018 cites W2168706118 @default.
• W3170703018 cites W2179591645 @default.
• W3170703018 cites W2204688218 @default.
• W3170703018 cites W2205012628 @default.
• W3170703018 cites W2210672989 @default.
• W3170703018 cites W2277004004 @default.
• W3170703018 cites W2341568598 @default.
• W3170703018 cites W2394977915 @default.
• W3170703018 cites W2399261310 @default.
• W3170703018 cites W2507408961 @default.
• W3170703018 cites W2508708811 @default.
• W3170703018 cites W2510135464 @default.
• W3170703018 cites W2512639960 @default.
• W3170703018 cites W2519289952 @default.
• W3170703018 cites W2521088029 @default.
• W3170703018 cites W2546338281 @default.
• W3170703018 cites W2567030468 @default.
• W3170703018 cites W2580009538 @default.
• W3170703018 cites W2606090907 @default.
• W3170703018 cites W2610773212 @default.
• W3170703018 cites W2611129198 @default.
• W3170703018 cites W2734724639 @default.
• W3170703018 cites W2743337080 @default.
• W3170703018 cites W2743667261 @default.
• W3170703018 cites W2743685074 @default.
• W3170703018 cites W2767038995 @default.
• W3170703018 cites W2770517007 @default.
• W3170703018 cites W2770913430 @default.
• W3170703018 cites W2771229928 @default.
• W3170703018 cites W2796459453 @default.
• W3170703018 cites W2799787792 @default.
• W3170703018 cites W2804174152 @default.
• W3170703018 cites W2807970930 @default.
• W3170703018 cites W2808368206 @default.
• W3170703018 cites W2809405444 @default.
• W3170703018 cites W2883728156 @default.
• W3170703018 cites W2886086463 @default.
• W3170703018 cites W2886906900 @default.
• W3170703018 cites W2888259312 @default.
• W3170703018 cites W2888434946 @default.
• W3170703018 cites W2890566837 @default.
• W3170703018 cites W2893288099 @default.
• W3170703018 cites W2901648284 @default.
• W3170703018 cites W2901791755 @default.
• W3170703018 cites W2909305085 @default.
• W3170703018 cites W2909892282 @default.
• W3170703018 cites W2914390742 @default.
• W3170703018 cites W2915480803 @default.
• W3170703018 cites W2920010073 @default.
• W3170703018 cites W2947017118 @default.
• W3170703018 cites W2948608119 @default.

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