FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3170703370> ?p ?o ?g. }

• W3170703370 endingPage "814" @default.
• W3170703370 startingPage "814" @default.
• W3170703370 abstract "Identification of physiologic factors that impede lactation is critical for developing interventions to support milk production. Our objective was to examine the role of tumor necrosis factor–alpha (TNF-A), a potent regulator of lipid metabolism, in the suppression of human lactation. We hypothesized that mothers with very low, versus sufficient milk production, would have elevated milk TNF-A and differential expression of TNF-A signaling pathways in the mammary epithelial cells (MECs). Among mothers in a study of low milk supply, extracellular mammary epithelial cell mRNA was isolated from fresh milk fat and submitted to RNA-sequencing. Aligned and quantified reads were examined for differentially expressed genes using t-tests (DEG, p < 0.05 after false discovery rate adjustment). We compared DEG in n = 5 with the lowest [LMP] (0–53 mL/24 h), and n = 4 with the highest [HMP] (422–463 mL/24 h) milk production in the sampled breast, using PPAR, TNF-Alpha, and fatty acid biosynthesis KEGG pathways. BMI, fasting serum triglycerides, and milk TNF-A were also assessed. Mean day postpartum (StdDev) was 32 (11) versus 47 (19) in LMP versus HMP, P > 0.05. Serum fasting triglyceride and BMI were significantly elevated in LMP versus HMP, P < 0.05. Median [min-max] TNF-A was 1.77 [0.64–6.89] pg/mL in LMP versus none detected in HMP (limit of detection, 0.50 pg/mL). Transcriptome analysis revealed 1.7-fold down regulation of lipoprotein lipase (LPL) in LMP versus HMP. PPARA and RXRA, regulatory factors upstream of LPL, were downregulated 1.8-fold. There was no difference in the expression of genes directly involved in fatty acid biosynthesis. Mothers with insufficient milk production have elevated milk TNF-A and a corresponding reduction in expression of lipid processing proteins known to be downregulated by TNF-A, notably LPL which is necessary for the hydrolysis of triglycerides into free fatty acids and glycerol for transport into MECs. We propose that TNF-A's disruption of critical fatty acid transport deprives the mammary gland of vital fuel and substrate towards the synthesis of human milk, without compensation through de novo lipid synthesis. Our findings shed light on TNF-A mediated lipid dysregulation as a potential link between obesity and insufficient lactation. NIH and USDA." @default.
• W3170703370 created "2021-06-22" @default.
• W3170703370 creator A5004910754 @default.
• W3170703370 creator A5009193794 @default.
• W3170703370 creator A5024177787 @default.
• W3170703370 creator A5030119098 @default.
• W3170703370 creator A5031877260 @default.
• W3170703370 creator A5051344816 @default.
• W3170703370 creator A5067346123 @default.
• W3170703370 creator A5069553970 @default.
• W3170703370 creator A5081040650 @default.
• W3170703370 creator A5083074489 @default.
• W3170703370 creator A5084328537 @default.
• W3170703370 date "2021-06-01" @default.
• W3170703370 modified "2023-10-16" @default.
• W3170703370 title "Chronic Elevation of Tumor Necrosis Factor-Alpha Suppresses Lactation via Downregulation of Lipoprotein Lipase" @default.
• W3170703370 doi "https://doi.org/10.1093/cdn/nzab046_111" @default.
• W3170703370 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8181817" @default.
• W3170703370 hasPublicationYear "2021" @default.
• W3170703370 type Work @default.
• W3170703370 sameAs 3170703370 @default.
• W3170703370 citedByCount "3" @default.
• W3170703370 countsByYear W31707033702022 @default.
• W3170703370 countsByYear W31707033702023 @default.
• W3170703370 crossrefType "journal-article" @default.
• W3170703370 hasAuthorship W3170703370A5004910754 @default.
• W3170703370 hasAuthorship W3170703370A5009193794 @default.
• W3170703370 hasAuthorship W3170703370A5024177787 @default.
• W3170703370 hasAuthorship W3170703370A5030119098 @default.
• W3170703370 hasAuthorship W3170703370A5031877260 @default.
• W3170703370 hasAuthorship W3170703370A5051344816 @default.
• W3170703370 hasAuthorship W3170703370A5067346123 @default.
• W3170703370 hasAuthorship W3170703370A5069553970 @default.
• W3170703370 hasAuthorship W3170703370A5081040650 @default.
• W3170703370 hasAuthorship W3170703370A5083074489 @default.
• W3170703370 hasAuthorship W3170703370A5084328537 @default.
• W3170703370 hasBestOaLocation W31707033701 @default.
• W3170703370 hasConcept C104317684 @default.
• W3170703370 hasConcept C121608353 @default.
• W3170703370 hasConcept C126322002 @default.
• W3170703370 hasConcept C127561419 @default.
• W3170703370 hasConcept C134018914 @default.
• W3170703370 hasConcept C171089720 @default.
• W3170703370 hasConcept C17991360 @default.
• W3170703370 hasConcept C185592680 @default.
• W3170703370 hasConcept C2776659692 @default.
• W3170703370 hasConcept C2778001805 @default.
• W3170703370 hasConcept C2778163477 @default.
• W3170703370 hasConcept C2778913445 @default.
• W3170703370 hasConcept C2779234561 @default.
• W3170703370 hasConcept C4733338 @default.
• W3170703370 hasConcept C530470458 @default.
• W3170703370 hasConcept C54355233 @default.
• W3170703370 hasConcept C55493867 @default.
• W3170703370 hasConcept C71924100 @default.
• W3170703370 hasConcept C86803240 @default.
• W3170703370 hasConcept C94879076 @default.
• W3170703370 hasConceptScore W3170703370C104317684 @default.
• W3170703370 hasConceptScore W3170703370C121608353 @default.
• W3170703370 hasConceptScore W3170703370C126322002 @default.
• W3170703370 hasConceptScore W3170703370C127561419 @default.
• W3170703370 hasConceptScore W3170703370C134018914 @default.
• W3170703370 hasConceptScore W3170703370C171089720 @default.
• W3170703370 hasConceptScore W3170703370C17991360 @default.
• W3170703370 hasConceptScore W3170703370C185592680 @default.
• W3170703370 hasConceptScore W3170703370C2776659692 @default.
• W3170703370 hasConceptScore W3170703370C2778001805 @default.
• W3170703370 hasConceptScore W3170703370C2778163477 @default.
• W3170703370 hasConceptScore W3170703370C2778913445 @default.
• W3170703370 hasConceptScore W3170703370C2779234561 @default.
• W3170703370 hasConceptScore W3170703370C4733338 @default.
• W3170703370 hasConceptScore W3170703370C530470458 @default.
• W3170703370 hasConceptScore W3170703370C54355233 @default.
• W3170703370 hasConceptScore W3170703370C55493867 @default.
• W3170703370 hasConceptScore W3170703370C71924100 @default.
• W3170703370 hasConceptScore W3170703370C86803240 @default.
• W3170703370 hasConceptScore W3170703370C94879076 @default.
• W3170703370 hasLocation W31707033701 @default.
• W3170703370 hasLocation W31707033702 @default.
• W3170703370 hasOpenAccess W3170703370 @default.
• W3170703370 hasPrimaryLocation W31707033701 @default.
• W3170703370 hasRelatedWork W1987822108 @default.
• W3170703370 hasRelatedWork W2013998010 @default.
• W3170703370 hasRelatedWork W2015809570 @default.
• W3170703370 hasRelatedWork W2026301838 @default.
• W3170703370 hasRelatedWork W2035484352 @default.
• W3170703370 hasRelatedWork W2052287651 @default.
• W3170703370 hasRelatedWork W2113401508 @default.
• W3170703370 hasRelatedWork W2132268865 @default.
• W3170703370 hasRelatedWork W2397699649 @default.
• W3170703370 hasRelatedWork W3030938700 @default.
• W3170703370 hasVolume "5" @default.
• W3170703370 isParatext "false" @default.
• W3170703370 isRetracted "false" @default.
• W3170703370 magId "3170703370" @default.
• W3170703370 workType "article" @default.