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- W3170705059 abstract "We studied the effects of training, exercise intensity, and [lactate] on gluconeogenesis (GNG) and hepatic glycogenolysis (GLY) in fasted men exercising at the lactate threshold (LT). Twelve men (6 untrained, 6 trained) completed 1 h of constant load exercise at power outputs (PO) corresponding to their LT. Trained men completed two additional 1-h exercise sessions at 10% below the LT (LT-10%), one of which included a lactate clamp (LT- 10%+LC). Relative exercise intensity was matched between the untrained at LT and the trained at LT-10%, and [lactate] was matched in the LT and LT-10%+LC trials. Flux rates were determined by primed continuous infusion of [6,6-2H2]glucose and [3-13C]lactate tracers. Exercise at LT corresponded to 67.6 ± 1.3 and 74.8 ± 1.7 %VO2peak in the untrained and trained men, respectively (P < 0.05). GNG was decreased in the trained men exercising at LT and LT-10% compared to the untrained men, but increasing [lactate] in the LT-10%+LC trial increased GNG (4.4 ± 0.9 mg·kg−1·min−1) compared to that in LT-10% (1.7 ± 0.4 mg·kg− 1·min−1, P < 0.05). Hepatic GLY was higher in the trained than untrained men. We conclude that GNG contributes ~25–40 % of glucose output during exercise in fasted men. While trained men can achieve a higher PO at the LT, this increase in exercise intensity is accompanied by a decrease in GNG, which can be recovered by raising [lactate]. This research was supported by a gift from CytoSport." @default.
- W3170705059 created "2021-06-22" @default.
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- W3170705059 date "2013-04-01" @default.
- W3170705059 modified "2023-09-27" @default.
- W3170705059 title "Gluconeogenesis and hepatic glycogenolysis during exercise at the lactate threshold" @default.
- W3170705059 doi "https://doi.org/10.1096/fasebj.27.1_supplement.1132.2" @default.
- W3170705059 hasPublicationYear "2013" @default.
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