Matches in SemOpenAlex for { <https://semopenalex.org/work/W3170709972> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W3170709972 abstract "Abstract Background Belatacept is a new non-nephrotoxic anti-rejection drug that blocks the CD80 / CD86-CD28 complex, that normally activates T lymphocytes. Although the BENEFIT study proposes its use at the forefront of immunosuppressive therapy to prevent renal transplant rejection, the risk of opportunistic infections should not be underestimated, as demonstrated by the following clinical case. Case report We report the case of a 71-year-old male kidney transplant recipient that at 7-month follow-up showed a relevant rise of serum creatinine up to 3.8 mg/dl related to graft rejection. The patient started a cycle of treatment with Belatacept in accomplishment to international studies, with improvement in renal function (serum creatinine: 2.8 mg/dl). After 8 months of therapy, due to the appearance of left brachio-crural hypoasthenia, a brain CT and a brain MRI (both without contrast media because of the severe graft dysfunction) were consecutively performed. Imaging revealed multiple nodular formations in the right hemisphere, compatible with brain abscesses or neuro-lymphoma. Belatacept was promptly suspended, a rachicentesis for liquor analysis performed, and a broad spectrum empiric antibiotic therapy was started on Infectious Disease Specialist advice. After Toxoplasma Gondii positivity was found by PCR on cerebrospinal fluid, neuro-lymphoma was excluded and the patient was switched to a targeted antibiotic therapy with Trimethoprim / Sulfamethoxazole (dose adjusted to renal function) for 6 weeks and subsequently, a maintenance course with Sulfadiazine and Pyrimethamine. During treatment, brain lesions showed progressive reduction, with marked clinical improvement and stabilization of renal function (eGFR 25 ml / min). Conclusions As far as is known in the literature, this is the first case of Toxoplasma Gondii brain infection that can be correlated with the use of Belactacept. The appearance of a severe opportunistic infection, in a short period of time after the introduction of Belatacept, could indicate the direct role of Belatacept in the development of these brain abscesses and indicates the importance of carefully evaluating the use of the drug in elderly patients with reduced renal function, in which adequate prophylactic therapy would be particularly indicated." @default.
- W3170709972 created "2021-06-22" @default.
- W3170709972 creator A5008647262 @default.
- W3170709972 creator A5013074872 @default.
- W3170709972 creator A5016571801 @default.
- W3170709972 creator A5019229078 @default.
- W3170709972 creator A5038817524 @default.
- W3170709972 creator A5047650157 @default.
- W3170709972 creator A5065517981 @default.
- W3170709972 creator A5085867013 @default.
- W3170709972 creator A5090068751 @default.
- W3170709972 date "2021-05-01" @default.
- W3170709972 modified "2023-10-16" @default.
- W3170709972 title "MO1003ONSET OF BRAIN TOXOPLASMA GONDII ABSCESSES IN RENAL TRANSPLANT RECIPIENT IN THERAPY WITH BELATACEPT" @default.
- W3170709972 doi "https://doi.org/10.1093/ndt/gfab111.0027" @default.
- W3170709972 hasPublicationYear "2021" @default.
- W3170709972 type Work @default.
- W3170709972 sameAs 3170709972 @default.
- W3170709972 citedByCount "1" @default.
- W3170709972 countsByYear W31707099722021 @default.
- W3170709972 crossrefType "journal-article" @default.
- W3170709972 hasAuthorship W3170709972A5008647262 @default.
- W3170709972 hasAuthorship W3170709972A5013074872 @default.
- W3170709972 hasAuthorship W3170709972A5016571801 @default.
- W3170709972 hasAuthorship W3170709972A5019229078 @default.
- W3170709972 hasAuthorship W3170709972A5038817524 @default.
- W3170709972 hasAuthorship W3170709972A5047650157 @default.
- W3170709972 hasAuthorship W3170709972A5065517981 @default.
- W3170709972 hasAuthorship W3170709972A5085867013 @default.
- W3170709972 hasAuthorship W3170709972A5090068751 @default.
- W3170709972 hasConcept C126189478 @default.
- W3170709972 hasConcept C126322002 @default.
- W3170709972 hasConcept C126894567 @default.
- W3170709972 hasConcept C141071460 @default.
- W3170709972 hasConcept C159641895 @default.
- W3170709972 hasConcept C2780091579 @default.
- W3170709972 hasConcept C2780303639 @default.
- W3170709972 hasConcept C2780743877 @default.
- W3170709972 hasConcept C2911091166 @default.
- W3170709972 hasConcept C2994498544 @default.
- W3170709972 hasConcept C71924100 @default.
- W3170709972 hasConceptScore W3170709972C126189478 @default.
- W3170709972 hasConceptScore W3170709972C126322002 @default.
- W3170709972 hasConceptScore W3170709972C126894567 @default.
- W3170709972 hasConceptScore W3170709972C141071460 @default.
- W3170709972 hasConceptScore W3170709972C159641895 @default.
- W3170709972 hasConceptScore W3170709972C2780091579 @default.
- W3170709972 hasConceptScore W3170709972C2780303639 @default.
- W3170709972 hasConceptScore W3170709972C2780743877 @default.
- W3170709972 hasConceptScore W3170709972C2911091166 @default.
- W3170709972 hasConceptScore W3170709972C2994498544 @default.
- W3170709972 hasConceptScore W3170709972C71924100 @default.
- W3170709972 hasLocation W31707099721 @default.
- W3170709972 hasOpenAccess W3170709972 @default.
- W3170709972 hasPrimaryLocation W31707099721 @default.
- W3170709972 hasRelatedWork W12432221 @default.
- W3170709972 hasRelatedWork W1323464 @default.
- W3170709972 hasRelatedWork W13390872 @default.
- W3170709972 hasRelatedWork W14519867 @default.
- W3170709972 hasRelatedWork W20761773 @default.
- W3170709972 hasRelatedWork W20858070 @default.
- W3170709972 hasRelatedWork W5787000 @default.
- W3170709972 hasRelatedWork W9466528 @default.
- W3170709972 hasRelatedWork W9662656 @default.
- W3170709972 hasRelatedWork W11929683 @default.
- W3170709972 isParatext "false" @default.
- W3170709972 isRetracted "false" @default.
- W3170709972 magId "3170709972" @default.
- W3170709972 workType "article" @default.