FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3170790811> ?p ?o ?g. }

• W3170790811 abstract "Background Despite successful ART in people living with HIV infection (PLHIV) they experience increased morbidity and mortality compared with HIV-negative controls. A dominant paradigm is that gut-associated lymphatic tissue (GALT) destruction at the time of primary HIV infection leads to loss of gut integrity, pathological microbial translocation across the compromised gastrointestinal barrier and, consequently, systemic inflammation. We aimed to identify and measure specific changes in the gastrointestinal barrier that might allow bacterial translocation, and their persistence despite initiation of antiretroviral therapy (ART). Method We conducted a cross-sectional study of the gastrointestinal (GIT) barrier in PLHIV and HIV-uninfected controls (HUC). The GIT barrier was assessed as follows: in vivo mucosal imaging using confocal endomicroscopy (CEM); the immunophenotype of GIT and circulating lymphocytes; the gut microbiome; and plasma inflammation markers Tumour Necrosis Factor-α (TNF-α) and Interleukin-6 (IL-6); and the microbial translocation marker sCD14. Results A cohort of PLHIV who initiated ART early, during primary HIV infection (PHI), n=5), and late (chronic HIV infection (CHI), n=7) infection were evaluated for the differential effects of the stage of ART initiation on the GIT barrier compared with HUC (n=6). We observed a significant decrease in the CD4 T-cell count of CHI patients in the left colon (p=0.03) and a trend to a decrease in the terminal ileum (p=0.13). We did not find evidence of increased epithelial permeability by CEM. No significant differences were found in microbial translocation or inflammatory markers in plasma. In gut biopsies, CD8 T-cells, including resident intraepithelial CD103+ cells, did not show any significant elevation of activation in PLHIV, compared to HUC. The majority of residual circulating activated CD38+HLA-DR+ CD8 T-cells did not exhibit gut-homing integrins α4ß7, suggesting that they did not originate in GALT. A significant reduction in the evenness of species distribution in the microbiome of CHI subjects (p=0.016) was observed, with significantly higher relative abundance of the genus Spirochaeta in PHI subjects (p=0.042). Conclusion These data suggest that substantial, non-specific increases in epithelial permeability may not be the most important mechanism of HIV-associated immune activation in well-controlled HIV-positive patients on antiretroviral therapy. Changes in gut microbiota warrant further study." @default.
• W3170790811 created "2021-06-22" @default.
• W3170790811 creator A5001285588 @default.
• W3170790811 creator A5003067288 @default.
• W3170790811 creator A5003820675 @default.
• W3170790811 creator A5026890702 @default.
• W3170790811 creator A5027244350 @default.
• W3170790811 creator A5048776233 @default.
• W3170790811 creator A5053124469 @default.
• W3170790811 creator A5054118077 @default.
• W3170790811 creator A5068421356 @default.
• W3170790811 creator A5085644815 @default.
• W3170790811 creator A5088309165 @default.
• W3170790811 date "2021-05-31" @default.
• W3170790811 modified "2023-10-13" @default.
• W3170790811 title "Preservation of Gastrointestinal Mucosal Barrier Function and Microbiome in Patients With Controlled HIV Infection" @default.
• W3170790811 cites W1253797328 @default.
• W3170790811 cites W1548246322 @default.
• W3170790811 cites W1618627661 @default.
• W3170790811 cites W1809324973 @default.
• W3170790811 cites W1824873223 @default.
• W3170790811 cites W1857710144 @default.
• W3170790811 cites W1977104590 @default.
• W3170790811 cites W1982204706 @default.
• W3170790811 cites W1990236675 @default.
• W3170790811 cites W1994827009 @default.
• W3170790811 cites W1997734228 @default.
• W3170790811 cites W2000924748 @default.
• W3170790811 cites W2004095293 @default.
• W3170790811 cites W2004107565 @default.
• W3170790811 cites W2006318786 @default.
• W3170790811 cites W2010605331 @default.
• W3170790811 cites W2015621374 @default.
• W3170790811 cites W2028630572 @default.
• W3170790811 cites W2029016685 @default.
• W3170790811 cites W2030173510 @default.
• W3170790811 cites W2030416759 @default.
• W3170790811 cites W2033326440 @default.
• W3170790811 cites W2033327108 @default.
• W3170790811 cites W2036505093 @default.
• W3170790811 cites W2046700010 @default.
• W3170790811 cites W2047385553 @default.
• W3170790811 cites W2050478480 @default.
• W3170790811 cites W2050669247 @default.
• W3170790811 cites W2052432894 @default.
• W3170790811 cites W2056548679 @default.
• W3170790811 cites W2061143375 @default.
• W3170790811 cites W2063276097 @default.
• W3170790811 cites W2067311108 @default.
• W3170790811 cites W2072970694 @default.
• W3170790811 cites W2076120354 @default.
• W3170790811 cites W2077786609 @default.
• W3170790811 cites W2082608049 @default.
• W3170790811 cites W2088968901 @default.
• W3170790811 cites W2090324498 @default.
• W3170790811 cites W2104439840 @default.
• W3170790811 cites W2105922002 @default.
• W3170790811 cites W2106082300 @default.
• W3170790811 cites W2120662329 @default.
• W3170790811 cites W2122483069 @default.
• W3170790811 cites W2132113202 @default.
• W3170790811 cites W2133836223 @default.
• W3170790811 cites W2134377316 @default.
• W3170790811 cites W2137091788 @default.
• W3170790811 cites W2147856029 @default.
• W3170790811 cites W2149492547 @default.
• W3170790811 cites W2150484278 @default.
• W3170790811 cites W2155770880 @default.
• W3170790811 cites W2161789287 @default.
• W3170790811 cites W2164541738 @default.
• W3170790811 cites W2167028239 @default.
• W3170790811 cites W2167062644 @default.
• W3170790811 cites W2170208941 @default.
• W3170790811 cites W2170850530 @default.
• W3170790811 cites W2314369511 @default.
• W3170790811 cites W2317659794 @default.
• W3170790811 cites W2319153630 @default.
• W3170790811 cites W2332416411 @default.
• W3170790811 cites W2336625848 @default.
• W3170790811 cites W2414537326 @default.
• W3170790811 cites W2470512478 @default.
• W3170790811 cites W2537711516 @default.
• W3170790811 cites W2572467248 @default.
• W3170790811 cites W2602749342 @default.
• W3170790811 cites W2612014054 @default.
• W3170790811 cites W2956862240 @default.
• W3170790811 cites W2992793004 @default.
• W3170790811 cites W2998705260 @default.
• W3170790811 cites W3027262121 @default.
• W3170790811 cites W3034482583 @default.
• W3170790811 cites W4232749557 @default.
• W3170790811 cites W4243838042 @default.
• W3170790811 doi "https://doi.org/10.3389/fimmu.2021.688886" @default.
• W3170790811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8203413" @default.
• W3170790811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34135912" @default.
• W3170790811 hasPublicationYear "2021" @default.
• W3170790811 type Work @default.
• W3170790811 sameAs 3170790811 @default.
• W3170790811 citedByCount "6" @default.
• W3170790811 countsByYear W31707908112022 @default.

• next