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- W3170812912 abstract "We have shown that genistin (GEN) and the mix of isoflavones (MIX) present at the concentrations in soy infant formula inhibited rotavirus (RV) infectivity in vitro. RV infection stimulates intracellular phosphorylation pathways and genistein is a protein tyrosine kinase inhibitor. Herein, the hypothesis that isoflavones reduce RV infectivity by inhibiting phosphorylation of protein kinases involved in MAPK and p70 signaling pathways was tested. RV infectivity was assessed in MA104 cells using a focus forming unit assay. GEN (14.16 mg/L), genistein (0.90 mg/L) and a MIX (GEN, genistein, daidzin, daidzein, glycitin; total 27.41 mg/L) were tested compared to a media control (CON). GEN, genistein and the MIX reduced RV infectivity by 64%, 32% and 69% (P≤0.05), respectively compared to CON. GEN, genistein and the MIX decreased JNK and p38 phosphorylation at baseline and 10h and 24h post-RV infection. GEN and the MIX also reduced phosphorylation of p70s6k and s6, but genistein did not significantly inhibit p70s6k and s6 phosphorylation. These findings contribute to a mechanistic basis for the inhibition of RV infectivity by isoflavones at concentrations present in soy infant formula. (Supported by the China Scholarship Council and USDA grant 2009-34505-19855)." @default.
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- W3170812912 date "2011-04-01" @default.
- W3170812912 modified "2023-09-23" @default.
- W3170812912 title "Isoflavones reduce rotavirus infectivity in MA104 cells through inhibition of protein kinases in the JNK and p70 signaling pathways" @default.
- W3170812912 doi "https://doi.org/10.1096/fasebj.25.1_supplement.772.12" @default.
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