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- W3170833985 abstract "Practice guidelines for adults with obsessive-compulsive disorder (OCD) recommend augmenting serotonin reuptake inhibitors (SRIs) with exposure and ritual prevention (EX/RP). However, fewer than half of patients remit after a standard 17-session EX/RP course. We studied whether extending the course increased overall remission rates and which patient factors predicted remission. Participants were 137 adults with clinically significant OCD (Yale-Brown Obsessive Compulsive Scale [Y-BOCS] score ≥18) despite an adequate SRI trial (≥12 weeks). Continuing their SRI, patients received 17 sessions of twice-weekly EX/RP (standard course). Patients who did not remit (Y-BOCS ≤12) received up to 8 additional sessions (extended course). Of 137 entrants, 123 completed treatment: 49 (35.8%) remitted with the standard course and another 46 (33.6%) with the extended course. Poorer patient homework adherence, more Obsessive-Compulsive Personality Disorder (OCPD) traits, and the Brain-Derived Neurotrophic Factor (BDNF) Val66MET genotype were associated with lower odds of standard course remission. Only homework adherence differentiated non-remitters from extended course remitters. Extending the EX/RP course from 17 to 25 sessions enabled many (69.3%) OCD patients on SRIs to achieve remission. Although behavioral (patient homework adherence), psychological (OCPD traits), and biological (BDNF genotype) factors influenced odds of EX/RP remission, homework adherence was the most potent patient factor overall. • We tested EX/RP as an SRI augmentation strategy for adults with OCD. • Extending EX/RP from 17 to 25 sessions of EX/RP enabled 69.3% of patients to achieve remission. • Patient adherence, OCPD traits, and BDNF genotype influenced the odds and timing of remission." @default.
- W3170833985 created "2021-06-22" @default.
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- W3170833985 date "2021-08-01" @default.
- W3170833985 modified "2023-10-15" @default.
- W3170833985 title "Maximizing remission from cognitive-behavioral therapy in medicated adults with obsessive-compulsive disorder" @default.
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- W3170833985 doi "https://doi.org/10.1016/j.brat.2021.103890" @default.
- W3170833985 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8241471" @default.
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