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- W3170900941 endingPage "243" @default.
- W3170900941 startingPage "225" @default.
- W3170900941 abstract "Growth hormone (GH)-secreting adenomas of the pituitary gland can cause acromegaly in adults and gigantism in children before fusion of bony epiphysis. The mortality rate in this patient population is significantly higher than the general population, with the most likely cause of death stemming from cardiac or vascular complications. Therefore treatment of the underlying adenoma is crucial. Currently, surgical tumor extirpation remains the treatment of choice, with high rates of durable endocrinological remission and low rates of adverse events. In patients with recurrence of tumor or endocrinopathy or those in poor general health, long-term targeted therapy with somatostatin analogues may be advised. Reoperation or radiation therapy remains as options for medically intractable growth hormone excess. Current advances in surgical techniques including endoscopy and intraoperative MRI imaging make the initial and repeat surgeries safe and effective in the management of acromegaly/gigantism." @default.
- W3170900941 created "2021-06-22" @default.
- W3170900941 creator A5035439902 @default.
- W3170900941 creator A5091098904 @default.
- W3170900941 date "2021-01-01" @default.
- W3170900941 modified "2023-09-25" @default.
- W3170900941 title "Surgical management of growth hormone-secreting adenomas" @default.
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