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• W3170905667 abstract "The cerebrospinal fluid (CSF) fills the ventricles, the cranial and spinal subarachnoid spaces. CSF exhibits a pulsatile motion essential to normal brain function and its flow dynamics disturbance is linked to several CSF diseases. A relevant hemodynamic parameter, the intracranial pressure, which can be acquired only invasively is closely related to CSF flow dynamics. The main goal of this study is to build, based on the hypothesis that the CSF displacement is mainly driven by the cerebral arterial pulsation, a one-dimensional model of the fluid mechanics coupling between the entire cerebral vasculature (CV) and the CSF. The CV is composed of 34 vessels depicting the arterial network, the microcirculation and the venous network. It starts from the carotid and vertebral arteries to the jugular veins and is surrounded by the cranial subarachnoid spaces. This cranial vault is then coupled to a spinal vault which consists of the spinal cord enclosed by the spinal subarachnoid spaces. Blood and CSF are considered viscous. The blood vessels and the dura mater are assumed compliants. The boundary conditions of the blood-CSF 1D model consist of an arterial pressure signal at the inlet of the carotid and vertebral arteries and a venous steady pressure at the jugular veins. First, a sinusoidal waveform of the arterial pressure signal is employed followed by a physiological waveform signal. The study evaluates the effect of the dura mater elastance, the CSF volume and the lumbar cistern compliance on blood and CSF dynamics as their contributions are closely related to CSF disorders. First, the model was able to reproduce the CSF flow pulsatility and fluids volume exchange between the cranial and spinal compartment. We found cervical CSF peak flow between 0.5 and 3 mL/s and cranial CSF pressure between 2 and 8 mmHg which is in agreement with MRI studies. Moreover, due to the compliant spinal subarachnoid spaces, pulse wave velocity and pulse pressure attenuation were find decreasing under increasing spinal compliance. A parametric analysis was conducted to quantify the effect of CSF volume and overall cranio-spinal compliance. Our results provide evidence of an optimal spinal CSF stroke volumefor a CSF volume of 216 mL. Moreover, cranial CSF pressure was found increasing under decreasing the overall cranio spinal compliance. Finally, the model was confronted to PC-MRI measurements and we found good agreement between computed and measured cervical CSF flow. This work constitutes the object of future studies regarding the modeling of the cerebral autoregulation mechanism as a retroactive optimal process." @default.
• W3170905667 created "2021-06-22" @default.
• W3170905667 creator A5079854486 @default.
• W3170905667 date "2019-06-18" @default.
• W3170905667 modified "2023-09-27" @default.
• W3170905667 title "A one dimensional numerical coupling of the cerebral vasculature and the cerebrospinal fluid flow in the cardio-spinal compartment" @default.
• W3170905667 hasPublicationYear "2019" @default.
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