Matches in SemOpenAlex for { <https://semopenalex.org/work/W3170951565> ?p ?o ?g. }
- W3170951565 abstract "Immune checkpoint inhibitor therapy has revolutionized the field of cancer immunotherapy. Even though it has shown a durable response in some solid tumors, several patients do not respond to these agents, irrespective of predictive biomarker (PD-L1, MSI, TMB) status. Multiple preclinical, as well as early-phase clinical studies are ongoing for combining immune checkpoint inhibitors with anti-cancer and/or non-anti-cancer drugs for beneficial therapeutic interactions. In this review, we discuss the mechanistic basis behind the combination of immune checkpoint inhibitors with other drugs currently being studied in early phase clinical studies including conventional chemotherapy drugs, metronomic chemotherapy, thalidomide and its derivatives, epigenetic therapy, targeted therapy, inhibitors of DNA damage repair, other small molecule inhibitors, anti-tumor antibodies hormonal therapy, multiple checkpoint Inhibitors, microbiome therapeutics, oncolytic viruses, radiotherapy, drugs targeting myeloid-derived suppressor cells, drugs targeting Tregs, drugs targeting renin-angiotensin system, drugs targeting the autonomic nervous system, metformin, etc. We also highlight how translational research strategies can help better understand the true therapeutic potential of such combinations." @default.
- W3170951565 created "2021-06-22" @default.
- W3170951565 creator A5032123166 @default.
- W3170951565 creator A5041762919 @default.
- W3170951565 creator A5058898862 @default.
- W3170951565 creator A5070451006 @default.
- W3170951565 creator A5083964909 @default.
- W3170951565 date "2021-05-28" @default.
- W3170951565 modified "2023-10-11" @default.
- W3170951565 title "Combination Strategies to Augment Immune Check Point Inhibitors Efficacy - Implications for Translational Research" @default.
- W3170951565 cites W1516453481 @default.
- W3170951565 cites W1572267688 @default.
- W3170951565 cites W1905278501 @default.
- W3170951565 cites W1953890763 @default.
- W3170951565 cites W1955732360 @default.
- W3170951565 cites W1957984040 @default.
- W3170951565 cites W1969848086 @default.
- W3170951565 cites W1970581364 @default.
- W3170951565 cites W1973091654 @default.
- W3170951565 cites W1977202406 @default.
- W3170951565 cites W1993869378 @default.
- W3170951565 cites W1994521878 @default.
- W3170951565 cites W2006124032 @default.
- W3170951565 cites W2013492504 @default.
- W3170951565 cites W2013687768 @default.
- W3170951565 cites W2041713021 @default.
- W3170951565 cites W2052874737 @default.
- W3170951565 cites W2054635400 @default.
- W3170951565 cites W2054953072 @default.
- W3170951565 cites W2057848975 @default.
- W3170951565 cites W2062601742 @default.
- W3170951565 cites W2066204710 @default.
- W3170951565 cites W2066264051 @default.
- W3170951565 cites W2078190084 @default.
- W3170951565 cites W2079315541 @default.
- W3170951565 cites W2080202443 @default.
- W3170951565 cites W2081654383 @default.
- W3170951565 cites W2089103836 @default.
- W3170951565 cites W2089228335 @default.
- W3170951565 cites W2091103707 @default.
- W3170951565 cites W2094546405 @default.
- W3170951565 cites W2096027620 @default.
- W3170951565 cites W2097995306 @default.
- W3170951565 cites W2100141308 @default.
- W3170951565 cites W2101653483 @default.
- W3170951565 cites W2101760296 @default.
- W3170951565 cites W2112601576 @default.
- W3170951565 cites W2113906692 @default.
- W3170951565 cites W2116054353 @default.
- W3170951565 cites W2116549767 @default.
- W3170951565 cites W2120304148 @default.
- W3170951565 cites W2121225884 @default.
- W3170951565 cites W2126932404 @default.
- W3170951565 cites W2128723862 @default.
- W3170951565 cites W2128769815 @default.
- W3170951565 cites W2130846254 @default.
- W3170951565 cites W2141186092 @default.
- W3170951565 cites W2142604595 @default.
- W3170951565 cites W2147579396 @default.
- W3170951565 cites W2153162429 @default.
- W3170951565 cites W2153980878 @default.
- W3170951565 cites W2157466080 @default.
- W3170951565 cites W2160571820 @default.
- W3170951565 cites W2160834915 @default.
- W3170951565 cites W2171524684 @default.
- W3170951565 cites W2172268423 @default.
- W3170951565 cites W2172537925 @default.
- W3170951565 cites W2201379305 @default.
- W3170951565 cites W2210453860 @default.
- W3170951565 cites W2224804004 @default.
- W3170951565 cites W2252550602 @default.
- W3170951565 cites W2269489462 @default.
- W3170951565 cites W2270967011 @default.
- W3170951565 cites W2294346158 @default.
- W3170951565 cites W2324902637 @default.
- W3170951565 cites W2396078839 @default.
- W3170951565 cites W2469758901 @default.
- W3170951565 cites W2524674719 @default.
- W3170951565 cites W2528861955 @default.
- W3170951565 cites W2531076089 @default.
- W3170951565 cites W2535549547 @default.
- W3170951565 cites W2537391848 @default.
- W3170951565 cites W2547161910 @default.
- W3170951565 cites W2552470435 @default.
- W3170951565 cites W2552978108 @default.
- W3170951565 cites W2554479252 @default.
- W3170951565 cites W2568946517 @default.
- W3170951565 cites W2598819900 @default.
- W3170951565 cites W2601380465 @default.
- W3170951565 cites W2606367731 @default.
- W3170951565 cites W2610269487 @default.
- W3170951565 cites W2620424811 @default.
- W3170951565 cites W2735939614 @default.
- W3170951565 cites W2740249739 @default.
- W3170951565 cites W2740867080 @default.
- W3170951565 cites W2750328162 @default.
- W3170951565 cites W2750781282 @default.
- W3170951565 cites W2756324556 @default.
- W3170951565 cites W2761911056 @default.
- W3170951565 cites W2761946249 @default.