FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3171003406> ?p ?o ?g. }

• W3171003406 abstract "Increasing evidence reveals that breast cancer stem cells (BCSCs) subtypes with distinct properties are regulated by their abnormal metabolic changes; however, the specific molecular mechanism and its relationship with tumor microenvironment (TME) are not clear. In this study, we explored the mechanism of lactate dehydrogenase A (LDHA), a crucial glycolytic enzyme, in maintaining cancer stemness and BCSCs plasticity, and promoting the interaction of BCSCs with tumor associated macrophages (TAMs). Firstly, the expression of LDHA in breast cancer tissues was much higher than that in adjacent tissues and correlated with the clinical progression and prognosis of breast cancer patients based on The Cancer Genome Atlas (TCGA) data set. Moreover, the orthotopic tumor growth and pulmonary metastasis were remarkable inhibited in mice inoculated with 4T1-shLdha cells. Secondly, the properties of cancer stemness were significantly suppressed in MDA-MB-231-shLDHA or A549-shLDHA cancer cells, including the decrease of ALDH + cells proportion, the repression of sphere formation and cellular migration, and the reduction of stemness genes (SOX2, OCT4, and NANOG) expression. However, the proportion of ALDH + cells (epithelial-like BCSCs, E-BCSCs) was increased and the proportion of CD44 + CD24 − cells (mesenchyme-like BCSCs, M-BCSCs) was decreased after LDHA silencing, suggesting a regulatory role of LDHA in E-BCSCs/M-BCSCs transformation in mouse breast cancer cells. Thirdly, the expression of epithelial marker E-cadherin, proved to interact with LDHA, was obviously increased in LDHA-silencing cancer cells. The recruitment of TAMs and the secretion of CCL2 were dramatically reduced after LDHA was knocked down in vitro and in vivo . Taken together, LDHA mediates a vicious cycle of mutual promotion between BCSCs plasticity and TAMs infiltration, which may provide an effective treatment strategy by targeting LDHA for breast cancer patients." @default.
• W3171003406 created "2021-06-22" @default.
• W3171003406 creator A5000183666 @default.
• W3171003406 creator A5001527458 @default.
• W3171003406 creator A5009592472 @default.
• W3171003406 creator A5016806891 @default.
• W3171003406 creator A5019574552 @default.
• W3171003406 creator A5023494911 @default.
• W3171003406 creator A5028637363 @default.
• W3171003406 creator A5034251759 @default.
• W3171003406 creator A5038221217 @default.
• W3171003406 creator A5056153599 @default.
• W3171003406 creator A5081533954 @default.
• W3171003406 date "2021-06-10" @default.
• W3171003406 modified "2023-10-18" @default.
• W3171003406 title "Lactate Dehydrogenase-A (LDH-A) Preserves Cancer Stemness and Recruitment of Tumor-Associated Macrophages to Promote Breast Cancer Progression" @default.
• W3171003406 cites W1833050134 @default.
• W3171003406 cites W1963904011 @default.
• W3171003406 cites W1971620413 @default.
• W3171003406 cites W2000799034 @default.
• W3171003406 cites W2002621152 @default.
• W3171003406 cites W2008273587 @default.
• W3171003406 cites W2009999719 @default.
• W3171003406 cites W2012361088 @default.
• W3171003406 cites W2014233861 @default.
• W3171003406 cites W2014691022 @default.
• W3171003406 cites W2018372624 @default.
• W3171003406 cites W2018947566 @default.
• W3171003406 cites W2028897202 @default.
• W3171003406 cites W2038009564 @default.
• W3171003406 cites W2046788126 @default.
• W3171003406 cites W2048177691 @default.
• W3171003406 cites W2057992829 @default.
• W3171003406 cites W2063632665 @default.
• W3171003406 cites W2083135484 @default.
• W3171003406 cites W2087688974 @default.
• W3171003406 cites W2115585914 @default.
• W3171003406 cites W2125315196 @default.
• W3171003406 cites W2170770040 @default.
• W3171003406 cites W2211797064 @default.
• W3171003406 cites W2224415831 @default.
• W3171003406 cites W2310958367 @default.
• W3171003406 cites W2517404896 @default.
• W3171003406 cites W2587862832 @default.
• W3171003406 cites W2589623897 @default.
• W3171003406 cites W2594615455 @default.
• W3171003406 cites W2604837817 @default.
• W3171003406 cites W2617691667 @default.
• W3171003406 cites W2792453555 @default.
• W3171003406 cites W2800500152 @default.
• W3171003406 cites W2810028506 @default.
• W3171003406 cites W2889189861 @default.
• W3171003406 cites W2914598210 @default.
• W3171003406 cites W3004733773 @default.
• W3171003406 cites W3095390420 @default.
• W3171003406 cites W587660556 @default.
• W3171003406 doi "https://doi.org/10.3389/fonc.2021.654452" @default.
• W3171003406 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8225328" @default.
• W3171003406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34178639" @default.
• W3171003406 hasPublicationYear "2021" @default.
• W3171003406 type Work @default.
• W3171003406 sameAs 3171003406 @default.
• W3171003406 citedByCount "9" @default.
• W3171003406 countsByYear W31710034062021 @default.
• W3171003406 countsByYear W31710034062022 @default.
• W3171003406 countsByYear W31710034062023 @default.
• W3171003406 crossrefType "journal-article" @default.
• W3171003406 hasAuthorship W3171003406A5000183666 @default.
• W3171003406 hasAuthorship W3171003406A5001527458 @default.
• W3171003406 hasAuthorship W3171003406A5009592472 @default.
• W3171003406 hasAuthorship W3171003406A5016806891 @default.
• W3171003406 hasAuthorship W3171003406A5019574552 @default.
• W3171003406 hasAuthorship W3171003406A5023494911 @default.
• W3171003406 hasAuthorship W3171003406A5028637363 @default.
• W3171003406 hasAuthorship W3171003406A5034251759 @default.
• W3171003406 hasAuthorship W3171003406A5038221217 @default.
• W3171003406 hasAuthorship W3171003406A5056153599 @default.
• W3171003406 hasAuthorship W3171003406A5081533954 @default.
• W3171003406 hasBestOaLocation W31710034061 @default.
• W3171003406 hasConcept C104317684 @default.
• W3171003406 hasConcept C107459253 @default.
• W3171003406 hasConcept C119056186 @default.
• W3171003406 hasConcept C121608353 @default.
• W3171003406 hasConcept C126322002 @default.
• W3171003406 hasConcept C145103041 @default.
• W3171003406 hasConcept C1491633281 @default.
• W3171003406 hasConcept C181199279 @default.
• W3171003406 hasConcept C207701140 @default.
• W3171003406 hasConcept C2776107976 @default.
• W3171003406 hasConcept C2777318727 @default.
• W3171003406 hasConcept C2777933648 @default.
• W3171003406 hasConcept C2779013556 @default.
• W3171003406 hasConcept C2779256057 @default.
• W3171003406 hasConcept C2780932548 @default.
• W3171003406 hasConcept C28328180 @default.
• W3171003406 hasConcept C2910680157 @default.
• W3171003406 hasConcept C3020616263 @default.
• W3171003406 hasConcept C502942594 @default.
• W3171003406 hasConcept C530470458 @default.
• W3171003406 hasConcept C54355233 @default.

• next