FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3171121036> ?p ?o ?g. }

• W3171121036 endingPage "228" @default.
• W3171121036 startingPage "212" @default.
• W3171121036 abstract "Molecular communications is a promising framework for the design of controlled-release drug delivery systems. Under this framework, drug carriers, diseased cells, and the channel in between are modeled as transmitters, absorbing receivers, and diffusive channel, respectively. However, existing works on drug delivery systems consider only simple drug carrier models, which limits their practical applicability. In this paper, we investigate diffusion-based spherical matrix-type drug carriers, which are employed in medical applications. In a matrix carrier, the drug molecules are dispersed in the matrix core and diffuse from the inner to the outer layers of the carrier once immersed in a dissolution medium. We derive the channel response of the matrix carrier transmitter for an absorbing receiver. The results are validated by particle-based simulations and compared with commonly used point and transparent spherical transmitters to highlight the necessity of considering practical models. Moreover, we show that a transparent spherical transmitter, with the drug molecules uniformly distributed over the entire volume, is a special case of the considered matrix system. For this case, we provide an analytical expression for the channel response. Furthermore, we derive a criterion for evaluating whether the release process or the channel dynamics are more important for the overall characteristics of the channel response of a drug delivery system. For the limiting regimes, where only the release process or only the channel determine the behavior of the end-to-end system, we propose closed-form approximations for the channel response. Finally, as a scenario of practical relevance, we investigate the channel responses for the release of common therapeutic drugs, e.g., doxorubicin, from a diblock copolymer micelle acting as drug carrier." @default.
• W3171121036 created "2021-06-22" @default.
• W3171121036 creator A5010330446 @default.
• W3171121036 creator A5033990377 @default.
• W3171121036 creator A5047773714 @default.
• W3171121036 creator A5051526773 @default.
• W3171121036 creator A5055838449 @default.
• W3171121036 creator A5065873874 @default.
• W3171121036 creator A5074561882 @default.
• W3171121036 creator A5089901662 @default.
• W3171121036 creator A5090980325 @default.
• W3171121036 date "2022-12-01" @default.
• W3171121036 modified "2023-10-15" @default.
• W3171121036 title "Channel Responses for the Molecule Release From Spherical Homogeneous Matrix Carriers" @default.
• W3171121036 cites W1980711204 @default.
• W3171121036 cites W1985342002 @default.
• W3171121036 cites W1987665529 @default.
• W3171121036 cites W1991671533 @default.
• W3171121036 cites W1997016506 @default.
• W3171121036 cites W1999501080 @default.
• W3171121036 cites W2005419668 @default.
• W3171121036 cites W2028892040 @default.
• W3171121036 cites W2032961593 @default.
• W3171121036 cites W2049647155 @default.
• W3171121036 cites W2060987031 @default.
• W3171121036 cites W2079958521 @default.
• W3171121036 cites W2086130473 @default.
• W3171121036 cites W2092630430 @default.
• W3171121036 cites W2092789735 @default.
• W3171121036 cites W2094794373 @default.
• W3171121036 cites W2096127659 @default.
• W3171121036 cites W2142196702 @default.
• W3171121036 cites W2148474843 @default.
• W3171121036 cites W2245394571 @default.
• W3171121036 cites W2260681306 @default.
• W3171121036 cites W2337761013 @default.
• W3171121036 cites W2555709803 @default.
• W3171121036 cites W2585631586 @default.
• W3171121036 cites W2586816391 @default.
• W3171121036 cites W2603023627 @default.
• W3171121036 cites W2604062862 @default.
• W3171121036 cites W2614985500 @default.
• W3171121036 cites W2618721336 @default.
• W3171121036 cites W2797861163 @default.
• W3171121036 cites W2887014845 @default.
• W3171121036 cites W2921594146 @default.
• W3171121036 cites W2957536894 @default.
• W3171121036 cites W2962940129 @default.
• W3171121036 cites W2963601543 @default.
• W3171121036 cites W3012874101 @default.
• W3171121036 cites W3043836968 @default.
• W3171121036 cites W3045999229 @default.
• W3171121036 cites W3099409659 @default.
• W3171121036 cites W3100991707 @default.
• W3171121036 cites W3127575390 @default.
• W3171121036 cites W4210496779 @default.
• W3171121036 cites W4230267674 @default.
• W3171121036 cites W601797399 @default.
• W3171121036 doi "https://doi.org/10.1109/tmbmc.2022.3182571" @default.
• W3171121036 hasPublicationYear "2022" @default.
• W3171121036 type Work @default.
• W3171121036 sameAs 3171121036 @default.
• W3171121036 citedByCount "0" @default.
• W3171121036 crossrefType "journal-article" @default.
• W3171121036 hasAuthorship W3171121036A5010330446 @default.
• W3171121036 hasAuthorship W3171121036A5033990377 @default.
• W3171121036 hasAuthorship W3171121036A5047773714 @default.
• W3171121036 hasAuthorship W3171121036A5051526773 @default.
• W3171121036 hasAuthorship W3171121036A5055838449 @default.
• W3171121036 hasAuthorship W3171121036A5065873874 @default.
• W3171121036 hasAuthorship W3171121036A5074561882 @default.
• W3171121036 hasAuthorship W3171121036A5089901662 @default.
• W3171121036 hasAuthorship W3171121036A5090980325 @default.
• W3171121036 hasBestOaLocation W31711210362 @default.
• W3171121036 hasConcept C106487976 @default.
• W3171121036 hasConcept C121332964 @default.
• W3171121036 hasConcept C127162648 @default.
• W3171121036 hasConcept C13245373 @default.
• W3171121036 hasConcept C159985019 @default.
• W3171121036 hasConcept C171250308 @default.
• W3171121036 hasConcept C192562407 @default.
• W3171121036 hasConcept C2779767902 @default.
• W3171121036 hasConcept C2779820397 @default.
• W3171121036 hasConcept C41008148 @default.
• W3171121036 hasConcept C47798520 @default.
• W3171121036 hasConcept C69357855 @default.
• W3171121036 hasConcept C76155785 @default.
• W3171121036 hasConcept C97355855 @default.
• W3171121036 hasConceptScore W3171121036C106487976 @default.
• W3171121036 hasConceptScore W3171121036C121332964 @default.
• W3171121036 hasConceptScore W3171121036C127162648 @default.
• W3171121036 hasConceptScore W3171121036C13245373 @default.
• W3171121036 hasConceptScore W3171121036C159985019 @default.
• W3171121036 hasConceptScore W3171121036C171250308 @default.
• W3171121036 hasConceptScore W3171121036C192562407 @default.
• W3171121036 hasConceptScore W3171121036C2779767902 @default.
• W3171121036 hasConceptScore W3171121036C2779820397 @default.
• W3171121036 hasConceptScore W3171121036C41008148 @default.

• next